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Category: life extension – Page 162

Study explores the cell-type-specific effects of aging and sex on human cortical neurons

Aging is known to have profound effects on the human brain, prompting changes in the composition of cells and the expression of genes, while also altering aspects of the interaction between genes and environmental factors. While past neuroscience studies have pinpointed many of the molecular changes associated with aging, the age-related genetic factors influencing specific neuron populations remains poorly understood.

Recent studies on flies, mice, primates and utilizing single-cell or single-nucleus RNA-sequencing and genetic experimental techniques shed new light on these cell-type-specific changes. For instance, they unveiled the effects of aging on in the mouse and human brain, associations between cell-specific changes and modified chromatin proteins, and the influence of DNA methylation in the aging of various tissues.

Researchers at University of California (UC) San Diego and Salk Institute recently carried out a study aimed at better understanding how both age and sex impact human cortical neurons at a single-cell level. Their findings, published in Neuron, offer new insights into how aging affects cell composition, gene expression and DNA methylation across human brain cell types, while also uncovering differences between gene expression and DNA methylation in females and males.

Why Transhumanism Is Unrealistic and Immoral

Here the notorious but eloquent transhumanism critic Wesley J. Smith takes a swipe at the quickly growing movement to overcome death with science. New story in Merion West!

“Utopians often produce evil because their movement’s aspirations become paramount —that is, more important than avoiding acts ‘traditionally perceived as immoral.’ If enough people follow Istvan on the transhuman roller coaster, people could eventually get hurt.”

“I’m not afraid of dying. I just don’t want to be there when it happens.” – Woody Allen.

In 2016, transhumanism proselytizer Zoltan Istvan ran for president promising to defeat death while touring the country in a bus redesigned to look like a coffin. It was a great gimmick that made him, perhaps, the most famous transhumanist in the world.

I know and like Istvan. I admire his indefatigable work ethic that has him writing hundreds of transhumanist-boosting columns and engaging in countless interviews (including by opponents like me). But his recent piece in Merion West “When We’re Overly Optimistic about the Pace of Life Extension Research” took a dark and disturbing turn. He warns that at the current pace of life-extending research, the transhumanist goal of living indefinitely will not be attained during his lifetime (based on a formula he concocted he calls, “the senescence inference”). In 2,131, he moans, our expected lifespan will “only” be 165 years, and it will take “well over a millennium to attain Methuselah-like lifespans nearing 1,000 years.”

Longevity Breakthrough: New Treatment Reverses Multiple Hallmarks of Aging

Researchers at The University of Texas MD Anderson Cancer Center have shown that therapeutically restoring ‘youthful’ levels of a specific subunit of the telomerase enzyme can significantly reduce the signs and symptoms of aging in preclinical models. If these findings are validated in clinical trials, they could have important therapeutic implications for age-related diseases such as Alzheimer’s, Parkinson’s, heart disease, and cancer.

The study, published in Cell, identified a small molecule compound that restores physiological levels of telomerase reverse transcriptase (TERT), which normally is repressed with the onset of aging. Maintenance of TERT levels in aged lab models reduced cellular senescence and tissue inflammation, spurred new neuron formation with improved memory, and enhanced neuromuscular function, which increased strength and coordination.

The researchers show that TERT functions not only to extend telomeres, but also acts as a transcription factor to affect the expression of many genes directing neurogenesis, learning and memory, cellular senescence, and inflammation.

Will artificial intelligence save us or kill us? | Us & Them | DW Documentary

Will artificial intelligence save us or kill us all? In Japan, AI-driven technology promises better lives for an aging population. But researchers in Silicon Valley are warning of untamable forces being unleashed– and even human extinction.

Will artificial intelligence make life better for humans or lead to our downfall? As developers race toward implementing AI in every aspect of our lives, it is already showing promise in areas like medicine. But what if it is used for nefarious purposes?

In Japan, the inventor and scientist behind the firm Cyberdyne is working to make life better for the sick and elderly. Professor Yoshiyuki Sankai’s robot suits are AI-driven exoskeletons used in rehabilitative medicine to help stroke victims and others learn to walk again. But he doesn’t see the benefits of AI ending there; he predicts a future world where AIs will live in harmony with humans as a new, benevolent species.

Yet in Silicon Valley, the cradle of AI development, there is an unsettling contradiction: a deep uncertainty among many developers about the untamable forces they are unleashing. Gabriel Mukobi is a computer science graduate student at Stanford who is sounding the alarm that AI could push us toward disaster– and even human extinction. He’s at the forefront of a tiny field of researchers swimming against the current to make sure AI is safe and beneficial for everyone.

What are the promises and perils of AI? And who gets to decide how it will be used?

#documentary #dwdocumentary #technology #AI #UsandThem.

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15 Best Longevity Foods

Did you know letting crushed garlic sit for 10+ minutes before cooking it helps preserve more of its healthy polyphenols from heat? I learned a bunch of similar tidbits while researching this article on the best longevity foods!

Want to know the best longevity foods that increase lifespan to add to your diet? We pored through hundreds of studies and made a list!

New Luminescent Material Could Be the Answer to Crumbling Infrastructure

A new material developed by Tohoku University records and stores stress history in structures through a luminescent effect, offering an innovative solution to monitor aging infrastructure without needing power or complex equipment.

Identifying deteriorating infrastructure can be as challenging as fixing it. However, researchers at Tohoku University have made this process easier with the development of an innovative new material.

The material responds to mechanical stimuli by recording stress history through a luminescent effect called an afterglow. This information is stored for a long time, and by applying the material to the surfaces of structures, researchers can observe changes in the afterglow to determine the amount of stress the material has experienced.

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