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The mammalian retina is a complex system consisting out of cones (for color) and rods (for peripheral monochrome) that provide the raw image data which is then processed into successive layers of neurons before this preprocessed data is sent via the optical nerve to the brain’s visual cortex. In order to emulate this system as closely as possible, researchers at Penn State University have created a system that uses perovskite (methylammonium lead bromide, MAPbX3) RGB photodetectors and a neuromorphic processing algorithm that performs similar processing as the biological retina.

Panchromatic imaging is defined as being ‘sensitive to light of all colors in the visible spectrum’, which in imaging means enhancing the monochromatic (e.g. RGB) channels using panchromatic (intensity, not frequency) data. For the retina this means that the incoming light is not merely used to determine the separate colors, but also the intensity, which is what underlies the wide dynamic range of the Mark I eyeball. In this experiment, layers of these MAPbX3 (X being Cl, Br, I or combination thereof) perovskites formed stacked RGB sensors.

The output of these sensor layers was then processed in a pretrained convolutional neural network, to generate the final, panchromatic image which could then be used for a wide range of purposes. Some applications noted by the researchers include new types of digital cameras, as well as artificial retinas, limited mostly by how well the perovskite layers scale in resolution, and their longevity, which is a long-standing issue with perovskites. Another possibility raised is that of powering at least part of the system using the energy collected by the perovskite layers, akin to proposed perovskite-based solar panels.

Researchers have for the first time characterized a unique molecular mechanism of the early stages of programmed cell death or apoptosis, a process which plays a crucial role in prevention of cancer.

The study, which is published June 2, 2023 in Science Advances, was led by Dr. Luke Clifton at the STFC ISIS Neutron and Muon Source (ISIS) in Oxfordshire, alongside co-lead Professor Gerhard Gröbner at the University of Umeå and partners at the European Spallation Source in Sweden. It is the most recent in a series of research collaborations by this team, investigating the responsible for apoptosis.

Apoptosis is essential for human life, and its disruption can cause to grow and not respond to cancer treatment. In , it is regulated by two proteins with opposing roles known as Bax and Bcl-2.

Surprisingly, the human studies consistently show that collagen supplements reverse the signs of skin aging.

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Don’t try finding Zuzalu on a map; it doesn’t exist anymore. It was a “pop-up city” conceived by the tech entrepreneur Vitalik Buterin, creator of Ethereum, and a group of like-minded people to facilitate co-living and collaboration in fields like crypto, network states, AI, and longevity. It was also, in substantial part, funded by Vitalik.

Zuzalu, located on the Adriatic coast of Montenegro, began its short history on March 25 and wound down on May 25. It was a complex and memorable phenomenon, and I’m wrapping my mind around a larger article in the works.

Usually, I don’t eat breakfast due to my intermittent fasting regimen, but in Zuzalu, breakfast, served at a particular local restaurant, was the healthiest meal of the day. Also, it was free (kudos to Vitalik, and more on that later). Most importantly, it was the place to meet new people.

A groundbreaking manifesto on living better and longer that challenges the conventional medical thinking on aging and reveals a new approach to preventing chronic disease and extending long-term health, from a visionary physician and leading longevity expert.

“One of the most important books you’ll ever read.”—Steven D. Levitt, New York Times bestselling author of Freakonomics

Wouldn’t you like to live longer? And better? In this operating manual for longevity, Dr. Peter Attia draws on the latest science to deliver innovative nutritional interventions, techniques for optimizing exercise and sleep, and tools for addressing emotional and mental health.

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In the pursuit of extending healthy human lifespans, scientists have achieved a remarkable breakthrough that marks a significant milestone in the field. Researchers from Taipei Medical University in Taiwan have uncovered a genetic modification in mice that can empower cancer-killing cells, increasing their effectiveness by two to seven times while extending their lifespan by up to 20 percent.

Building upon last year’s groundbreaking study, the scientists have now successfully replicated these extraordinary outcomes in ordinary mice through a single transplant of blood stem cells. The findings, published in the scientific journal Cold Spring Harbor Protocols, hold immense importance, according to Che-Kun James Shen, the lead researcher of the study. He believes that these findings could have profound implications for human health and anticipates that clinical trials could commence as early as the end of this year or next year.

The initial discovery involved identifying an amino acid, known as KLF1, that, when altered, preserves the youthful characteristics of the mice. This includes improved motor function, enhanced learning and memory, as well as more effective anti-cancer cells. Additionally, the mice exhibited darker and shinier hair, and a significant reduction in fibrosis—a process associated with impaired organ functioning that occurs during aging.

Age-related hearing loss impacts one in three adults between the ages of 64 and 75 in the US, and around half of these numbers are down to genes.

The extra kicker, though, is that because hearing involves a complex genetic toolkit, it also makes this kind of hearing loss incredibly difficult to treat.

A team of researchers has for the first time targeted age-related genetic hearing loss in a much older cohort of mice, which had a mutation of the human transmembrane serine protease 3 (TMPRSS3) gene that results in autosomal recessive deafness 8/10 (DFNB8/DFNB10).

Glioblastoma Multiforme (GBM) is the most aggressive and most common primary malignant brain tumor. The age of GBM patients is considered as one of the disease’s negative prognostic factors and the mean age of diagnosis is 62 years. A promising approach to preventing both GBM and aging is to identify new potential therapeutic targets that are associated with both conditions as concurrent drivers. In this work, we present a multi-angled approach of identifying targets, which takes into account not only the disease-related genes but also the ones important in aging. For this purpose, we developed three strategies of target identification using the results of correlation analysis augmented with survival data, differences in expression levels and previously published information of aging-related genes.

I quoted and responded to this remark:

“…we probably will not solve death and this actually shouldn’t be our goal.” Well nice as she seems thank goods Dr Levine does not run the scientific community involved in rejuvenation.

The first bridge looks like it’s going to be plasma dilution and this may come to the general population in just a few short years. People who have taken this treatment report things like their arthritis and back pain vanishing.

After that epigentic programming to treat things that kill you in old age. And so on, bridge after bridge. if you have issues with the future, some problem with people living as long as they like, then by all means you have to freedom to grow old and die. That sounds mean but then I think it’s it’s mean to inform me I have to die because you think we have to because of “progress”. But this idea that living for centuries or longer is some horrible moral crime just holds no water.