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Putting the Brakes on Chronic Inflammation

Scientists at Weill Cornell Medicine discovered a previously unknown link between two key pathways that regulate the immune system in mammals — a finding that impacts our understanding of chronic inflammatory bowel diseases (IBD). This family of disorders severely impacts the health and quality of life of more than 2 million people in the United States.

The immune system has many pathways to protect the body from infection, but sometimes an overactive immune response results in autoimmune diseases including IBD, psoriasis, rheumatoid arthritis and multiple sclerosis. Interleukin-23 (IL-23) is one such immune factor that fights infections but is also implicated in many of these inflammatory diseases. However, it was unknown why IL-23 is sometimes beneficial, and other times becomes a driver of chronic disease.

In the study, published June 12 in Nature, the team found that IL-23 acts on group 3 innate lymphoid cells (ILC3s), a family of immune cells that are a first line of defense in mucosal tissues such as the intestines and lungs. In response, ILC3s increase activity of CTLA-4, a key regulatory factor that prevents the immune system from attacking the body and beneficial gut microbiota. This interaction critically balances the pro-inflammatory effects IL-23 to maintain gut health, but is impaired in IBD.

Dr. Jeffrey DellaVolpe, MD — Saving Lives With Extracorporeal Membrane Oxygenation (ECMO) Technology

Is Medical Director of the Adult Extracorporeal Membrane Oxygenation (ECMO) Program at Methodist Hospital, San Antonio, Texas. He is also the Medical Director of the Cardiovascular Intensive Care Unit at Methodist Healthcare System and the Texas IPS Critical Care Service Line (https://texasips.com/jeffrey-dellavol…). He also serves as chair of the Joint Society of Critical Care Medicine/Extracorporeal Life Support Organization Task Force and has created a platform for ECMO training and ECMO transport (https://ecmotransports.com/about/).

ECMO is a form of extracorporeal life support, providing prolonged cardiac and respiratory support to persons whose heart and lungs are unable to provide an adequate amount of oxygen, gas exchange or blood supply (perfusion) to sustain life.

Dr. DellaVolpe served as a Flight Surgeon with the 27th Special Operations Wing where he deployed twice in support of Operation Enduring Freedom – Trans Sahara. After completing his fellowship, he was assigned to the San Antonio Military Medical Center where he served as a critical care physician and a member of the 59th Medical Wing Critical Care Air Transport Team and Acute Lung Rescue Team.

Dr. DellaVolpe is originally from Newport, RI. After receiving his bachelor’s degree at Dartmouth College, he went on to attend medical school at Tulane University School of Medicine. He then completed his residency in Internal Medicine at Tulane Medical Center and his fellowship in Critical Care Medicine at the University of Pittsburgh Medical Center.

Dr. DellaVolpe wrote The ECMO Book, published Elsevier Health Sciences, in 2023 (https://www.us.elsevierhealth.com/the…).

#JeffreyDellaVolpe #MedicalDirector #ExtracorporealMembraneOxygenation #ECMO #MethodistHospital #SanAntonio #Texas #Cardiovascular #IntensiveCare #CriticalCare #LifeSupport #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #ViralPodcast #STEM #Innovation #Technology #Science #Research

Thomas Hartung and colleagues | The future of organoid intelligence | Frontiers Forum Deep Dive 2023

Eexxeccellent.


Human brains outperform computers in many forms of processing and are far more energy efficient. What if we could harness their power in a new form of biological computing?

In this Frontiers Forum Deep Dive session on 21 June 2023, Professor Thomas Hartung, Dr Lena Smirnova and other renowned researchers, explored the future of organoid intelligence and the scientific, technological and ethical steps required for realizing its full potential.

The session brought together the authors of the Frontiers in Science lead article ‘Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish’ which presents a roadmap for the strategic development of organoid intelligence as a scientific discipline. It was attended by hundreds of representatives from science, policy, and business across the world.

Links:

MIT engineers find a way to protect microbes from extreme conditions

Microbes that are used for health, agricultural, or other applications need to be able to withstand extreme conditions, and ideally the manufacturing processes used to make tablets for long-term storage. MIT researchers have now developed a new way to make microbes hardy enough to withstand these extreme conditions.

Their method involves mixing bacteria with food and drug additives from a list of compounds that the FDA classifies as “generally regarded as safe.” The researchers identified formulations that help to stabilize several different types of microbes, including yeast and bacteria, and they showed that these formulations could withstand high temperatures, radiation, and industrial processing that can damage unprotected microbes.

Would Astronauts’ Kidneys Survive a Roundtrip to Mars?

The structure and function of the kidneys is altered by space flight, with galactic radiation causing permanent damage that would jeopardise any mission to Mars, according to a new study led by researchers from UCL.

The study, published in Nature Communications, is the largest analysis of kidney health in space flight to date and includes the first health dataset for commercial astronauts. It is published as part of a Nature special collection of papers on space and health.

Researchers have known that space flight causes certain health issues since the 1970s, in the years after humans first travelled beyond Earth’s magnetic field, most famously during the first moon landing in 1969. These issues include loss of bone mass, weakening of the heart and eyesight, and development of kidney stones.

Even short trips to space can change an astronaut’s biology − a new set of studies offers the most comprehensive look at spaceflight health since NASA’s Twins Study

Editor’s note: Video above is about a NASA astronaut discussing an extended stay in space.

(THE CONVERSATION) – Only about 600 people have ever traveled to space. The vast majority of astronauts over the past six decades have been middle-aged men on short-duration missions of fewer than 20 days.

Today, with private, commercial and multinational spaceflight providers and flyers entering the market, we are witnessing a new era of human spaceflight. Missions have ranged from minutes, hours and days to months.

Systemic Therapy Approaches for Advanced Prostate Cancer

As part of the 2024 Prostate Cancer Patient Conference, Dr. Eric Small discusses systemic therapy treatment in advanced prostate cancer, including AR-targeted therapy. The presentation includes definitions of disease states, categories of treatment types, and standards in treatment selection.
Recorded on 03/09/2024. [Show ID: 39768]

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Engineers find a way to protect microbes from extreme conditions

Microbes that are used for health, agricultural, or other applications need to be able to withstand extreme conditions, and ideally the manufacturing processes used to make tablets for long-term storage. MIT researchers have now developed a new way to make microbes hardy enough to withstand these extreme conditions.

Their method involves mixing bacteria with food and drug additives from a list of compounds that the FDA classifies as “generally regarded as safe.” The researchers identified formulations that help to stabilize several different types of microbes, including yeast and bacteria, and they showed that these formulations could withstand high temperatures, radiation, and industrial processing that can damage unprotected microbes.

In an even more extreme test, some of the microbes recently returned from a trip to the International Space Station, coordinated by Space Center Houston Manager of Science and Research Phyllis Friello, and the researchers are now analyzing how well the microbes were able to withstand those conditions.

Novel 3D stretchable electronic strip could spark new possibilities for wearable e-textiles

Researchers have developed a novel 3D stretchable electronic strip which is expected to open up a range of new possibilities in wearable electronic textiles.

A team at Nottingham Trent University’s Medical Technologies Innovation Facility has led the work, which has paved the way for a new generation of electronic devices which could be embedded in clothing for possible use in health care and elite sports settings.

The research, which also involved industry partner Kymira Ltd, is published in Scientific Reports.

Tiny Crop-Health Sensors could help Cut the Cost of Groceries

A compact, lightweight sensor system with infrared imaging capabilities developed by an international team of engineers could be easily fitted to a drone for remote crop monitoring.

This flat-optics technology has the potential to replace traditional optical lens applications for environmental sensing in a range of industries.

This innovation could result in cheaper groceries as farmers would be able to pinpoint which crops require irrigation, fertilization and pest control, instead of taking a one-size-fits-all approach, thereby potentially boosting their harvests.