Lifeboat Foundation

Scientists at the University of Cambridge have successfully trialed an artificial pancreas for use by patients living with type 2 diabetes. The device – powered by an algorithm developed at the University of Cambridge – doubled the amount of time patients were in the target range for glucose compared to standard treatment and halved the time spent experiencing high glucose levels.

Around 415 million people worldwide are estimated to be living with type 2 diabetes, which costs around $760 billion in annual global health expenditure. According to Diabetes UK, more than 4.9 million people have diabetes in the UK alone, of whom 90% have type 2 diabetes, and this is estimated to cost the NHS £10 billion per year.

“Many people with type 2 diabetes struggle to manage their blood sugar levels using the currently available treatments, such as insulin injections. The artificial pancreas can provide a safe and effective approach to help them, and the technology is simple to use and can be implemented safely at home.” —

Fungi such as Aspergillus are so common in our surroundings that we breathe in hundreds to thousands of spores every day. In healthy people, fungi typically pose no threat, but they can cause deadly infections in those with compromised immune systems. However, it is increasingly recognized that viral infections such as influenza or SARS-CoV-2 can increase the risk of invasive Aspergillus infections even in healthy people.

The World Health Organization (WHO) has stated that invasive fungal infections are an increasing threat to human health and has reiterated that more research is needed. Until now little was known about how the Aspergillus fungus was able to take root, and what could be done to get rid of it. Researchers at the University of Calgary working with researchers at McGill University have provided new insight on why the immune system fails.

“We discovered that influenza and COVID-19 destroy a previously unknown natural immunity that we need to resist invasive fungal infections,” says Nicole Sarden, a Ph.D. candidate at the University of Calgary and first author on the study.

Simon Waslander is the Director of Collaboration, at the CureDAO Alliance for the Acceleration of Clinical Research (https://www.curedao.org/), a community-owned platform for the precision health of the future.

CureDAO is creating an open-source platform to discover how millions of factors, like foods, drugs, and supplements affect human health, within a decentralized autonomous organization (DAO), making suffering optional through the creation of a “WordPress of health data”.

Continue reading “Open-Sourcing And Accelerating Precision Health Of The Future: Progress, Potential and Possibilities Podcast episode” »

Mosquitoes that transmit dengue and other viruses have evolved growing resistance to insecticides in parts of Asia, and novel ways to control them are desperately needed, new research warns.

Health authorities commonly fog mosquito-infested areas with clouds of insecticide, and resistance has long been a concern, but the scale of the problem was not well understood.

Japanese scientist Shinji Kasai and his team examined mosquitos from several countries in Asia as well as Ghana and found a series of mutations had made some virtually impervious to popular pyrethroid-based chemicals like permethrin.

New tools are steadily bridging this gap. And ongoing development of one particular technique, cryo-electron tomography, or cryo-ET, has the potential to deepen how researchers study and understand how cells function in health and disease.

As the former editor-in-chief of Science magazine and as a researcher who has studied hard-to-visualize large protein structures for decades, I have witnessed astounding progress in the development of tools that can determine biological structures in detail. Just as it becomes easier to understand how complicated systems work when you know what they look like, understanding how biological structures fit together in a cell is key to understanding how organisms function.

New study claims an increase in mice median remaining lifespan of 109% via Gene Therapy Mediated Partial Reprogramming.

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Continue reading “Epigenetic Reprogramming Extends Remaining Lifespan” »

Ralph Lydic, professor in the UT Department of Psychology, and Dmitry Bolmatov, a research assistant professor in the UT Department of Physics and Astronomy, are part of a UT/ORNL research team studying how bio-inspired materials might inform the design of next-generation computers. Their results, published recently in the Proceedings of the National Academy of Sciences, could have big implications for both edge computing and human health.

Scientists at ORNL and UT discovered an artificial cell membrane is capable of long-term potentiation, or LTP, a hallmark of biological learning and memory. This is the first evidence that a cell membrane alone—without proteins or other biomolecules embedded within it—is capable of LTP that persists for many hours. It is also the first identified nanoscale structure in which memory can be encoded.

“When facilities were shut down as a result of COVID, this led us to pivot away from our usual membrane research,” said John Katsaras, a biophysicist in ORNL’s Neutron Sciences Directorate specializing in neutron scattering and the study of biological membranes at ORNL. “Together with postdoc Haden Scott, we decided to revisit a system previously studied by Pat Collier and co-workers, this time with an entirely different electrical stimulation protocol that we termed ‘training.’”.

A variety of healthy eating patterns are linked to reduced risk of premature death, according to a new study led by Harvard T.H. Chan School of Public Health researchers. They found that participants who scored high on adherence to at least one of four healthy eating patterns were less likely to die during the study period from any cause and less likely to die from cardiovascular disease, cancer, or respiratory disease, compared with people with lower scores. The findings are consistent with the current Dietary Guidelines for America, which recommend multiple healthy eating patterns.

“The Dietary Guidelines for Americans are intended to provide science-based dietary advice that promotes good health and reduces major chronic diseases. Thus, it is critical to examine the associations between DGAs-recommended dietary patterns and long-term health outcomes, especially mortality,” said corresponding author Frank Hu, Fredrick J. Stare Professor of Nutrition and Epidemiology and chair of the Department of Nutrition.

The study will be published online January 9, 2023, in JAMA Internal Medicine.

Pioneering Hematopoietic Stem Cell Transplants (HSCT) For Autoimmune Disorders — Dr. Richard K. Burt

Dr. Richard K. Burt MD (https://astemcelljourney.com/about/drrichardburt/) is a Fulbright Scholar, Professor of Medicine at Scripps Health Care, tenured retired Professor of Medicine at Northwestern University where he served as Chief of Immunotherapy and Autoimmune Diseases, and CEO of Genani Biotechnology.

Continue reading “Dr. Richard Burt MD — Pioneering Hematopoietic Stem Cell Transplants (HSCT) For Autoimmune Disorders” »