Lifeboat Foundation

Researchers at the National Institutes of Health have developed a way to potentially increase the effectiveness of T cell–based immunotherapy treatments, such as CAR T-cell therapy, against solid tumors. T cells are specialized white blood cells of the immune system that eliminate infected or abnormal cells. In animal studies, the enhanced T-cell therapies were effective against cervical cancer and neuroblastoma, a common solid tumor in children. The findings, by scientists at the National Cancer Institute (NCI), part of NIH, appear in Clinical Cancer Research.

CAR T-cell therapy is a form of cellular immunotherapy that involves engineering T cells in the laboratory so they can specifically target and kill tumors. CAR T-cell therapy has been successful in treating blood cancers, but it hasn’t worked well for solid tumors. To improve the effectiveness of T-cell therapy against solid tumors, researchers at NCI’s Center for Cancer Research engineered T cells (CAR T cells and another form of cellular immunotherapy called TCR T cells) to carry cytokines, which are proteins that can boost T-cell function.

In laboratory studies, CAR and TCR T cells modified to express the cytokines IL-15 and IL-21 on their surface killed far more cancer cells than T cells carrying just one of these cytokines or neither of them. Previous research has found that treating patients with large amounts of cytokines caused severe, potentially fatal, side effects. The new approach aims to deliver this cytokine boost in a much more targeted way.

The robot guide dog possesses the ability to respond to tugs on a leash.

Researchers have created a robot guide dog to make life easier for the visually impaired with its ability to respond to tugs on a leash. The team of engineers at Binghamton University’s Computer Science Department in New York State has been developing a robotic seeing-eye dog to improve accessibility for those who are visually impaired. Last year, they performed a trick-or-treating exercise with its quadruped robotic dog.

Now, they have demonstrated a robot dog leading a person down a lab hallway, confidently and carefully reacting to directive instructions. Engineers were surprised that throughout the visually impaired… More.

Continue reading “Engineers create a robotic eye-seeing dog to aid the visually impaired” »

Nanotechnology sounds like a futuristic development, but we already have it in the form of CPU manufacturing. More advanced nanotech could be used to create independent mobile entities like nanobots. One of the main challenges is selecting the right chemicals, elements, and structures that actually perform a desired task. Currently, we create more chemically oriented than computationally oriented nanobots, but we still have to deal with the quantum effects at tiny scale.

One of the most important applications of nanotechnology is to create nanomedicine, where the technology interacts with biology to help resolve problems. Of course, the nanobots have to be compatible with the body (e.g. no poisonous elements if they were broken down, etc).

Continue reading “How nanobots and nanomedicine will improve our health” »

Colorectal cancer screening is widely recommended for adults ages 45 to 75 with an average risk of developing the disease. However, many people don’t realize that the benefits of screening for this type of cancer aren’t always the same for older adults.

“While many clinicians simply follow guideline recommendations for colon cancer screening in adults within this age range, this isn’t always the best approach,” said Sameer Saini, M.D., M.S., who is a gastroenterologist at both Michigan Medicine and the Lieutenant Colonel Charles S. Kettles VA Medical Center and is as a health services researcher at the University of Michigan Institute for Healthcare Policy and Innovation and the Ann Arbor VA Center for Clinical Management Research, or CCMR.

“As individuals get older, they often acquire health problems that can lead to potential harm when coupled with endoscopy. While guidelines recommend a personalized approach to screening in average risk individuals between ages 76 and 85, there are no such recommendations for older adults who are younger than age 76—individuals who we commonly see in our clinics.”

Google’s new technique works by sending low-intensity ultrasonic probing signals via the speakers.

Researchers at Google have devised a technology that allows active noise-canceling (ANC) wearables to feature health-sensing applications.

The team utilized a technique called audio plethysmography (APG) in ANC wearables to monitor a user’s physiological data, such as heart rate and heart rate variability, without the need for additional sensors or sacrificing battery life.

🌐🧠🚨

In a recent study published in the Journal of Psychiatric Research, researchers describe the relationship between problematic internet use (PIU) and the symptoms of attention deficit hyperactivity disorder (ADHD).

Study: The relationship between problematic internet use and attention deficit, hyperactivity and impulsivity: A meta-analysis. Image Credit: Alexxndr / Shutterstock.com

Continue reading “Surfing the web too much? Study links problematic internet use to heightened ADHD symptoms” »

Exercise offers benefits for those with type 1 diabetes, but needs careful blood glucose management. Anaerobic & aerobic exercise cause different responses-optimize nutrition, insulin dosing & monitoring to reach target ranges & reduce dysglycemia risk.

Type 1 diabetes mellitus is an autoimmune disease caused by affected individuals’ autoimmune response to their own pancreatic beta-cell. It affects millions of people worldwide. Exercise has numerous health and social benefits for patients with type 1 diabetes mellitus; however, careful management of blood glucose is crucial to minimize the risk of hypoglycemia and hyperglycemia. Anaerobic and aerobic exercises cause different glycemic responses during and after exercise, each of which will affect athletes’ ability to reach their target blood glucose ranges. The optimization of the patient’s macronutrient consumption, especially carbohydrates, the dosage of basal and short-acting insulin, and the frequent monitoring of blood glucose, will enable athletes to perform at peak levels while reducing their risk of dysglycemia. Despite best efforts, hypoglycemia can occur.

Startup Twin Health is developing a program that uses sensor data to construct a replica of a person’s metabolism and then simulate virtual interventions on the body. The simulations suggest non-drug recommendations that help reverse metabolic disorders such as diabetes.

FOLLOW US
- Subscribe to ZDNet on YouTube: http://bit.ly/2HzQmyf.
- Watch more ZDNet videos: http://zd.net/2Hzw9Zy.
- Follow ZDNet on Twitter: https://twitter.com/ZDNet.
- Follow ZDNet on Facebook: https://www.facebook.com/ZDNet.
- Follow ZDNet on Instagram: https://www.instagram.com/ZDNet_CBSi.
- Follow ZDNet on LinkedIn: https://www.linkedin.com/company/zdnet-com/
- Follow ZDNet on Snapchat: https://www.snapchat.com/add/zdnet_cbsi

Mammalian cells may consume bacteriophages to promote cellular health and survival.