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Category: health – Page 39

A UCLA Health study explored the traits of resilient individuals, discovering significant neural activities in the brain regions for cognition and emotional regulation, and healthy gut microbiome activities.

The research highlighted differences in microbiome metabolites and gene activity, indicating lower inflammation and better gut health in resilient people compared to less resilient individuals. This comprehensive approach may lead to interventions that enhance resilience to stress, possibly preventing various health issues.

Resilience and Health.

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What You Should Know:

– A glimmer of hope emerged today for rectal cancer patients as a collaborative effort between Case Western Reserve University (CWRU), Cleveland Clinic, and University Hospitals (UH) received a $2.78 million grant over five years from the National Institutes of Health and National Cancer Institute. This grant will fuel research leveraging artificial intelligence (AI) to personalize treatment for rectal cancer patients.

– The new research effort signifies a significant step forward in the fight against rectal cancer. By harnessing the power of AI, researchers are on the path to developing more precise treatment strategies, ultimately improving patient outcomes and quality of life.

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Robots with human skin.

In a breakthrough that isn’t at all creepy, scientists have devised a method of anchoring living human skin to robots’ faces. The technology could actually have some valuable applications, beyond making Westworld-like scenarios a reality.

Two years ago, Prof. Shoji Takeuchi and colleagues at the University of Tokyo successfully covered a motorized robotic finger with a bioengineered skin made from live human cells.

It was hoped that this proof-of-concept exercise might pave the way not only for more lifelike android-type robots, but also for bots with self-healing, touch-sensitive coverings. The technology could additionally be used in the testing of cosmetics, and the training of plastic surgeons.

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Brain-inspired neuromorphic computing and portable intelligent electronic products have received increasing attention. In the present work, nanocellulose-gated indium tin oxide neuromorphic transistors are fabricated. The device exhibits good electrical performance. Short-term synaptic plasticities were mimicked, including excitatory postsynaptic current, paired-pulse facilitation, and dynamic high-pass synaptic filtering. Interestingly, an effective linear synaptic weight updating strategy was adopted, resulting in an excellent recognition accuracy of ∼92.93% for the Modified National Institute of Standard and Technology database adopting a two-layer multilayer perceptron neural network. Moreover, with unique interfacial protonic coupling, anxiety disorder behavior was conceptually emulated, exhibiting “neurosensitization”, “primary and secondary fear”, and “fear-adrenaline secretion-exacerbated fear”. Finally, the neuromorphic transistors could be dissolved in water, demonstrating potential in “green” electronics. These findings indicate that the proposed oxide neuromorphic transistors would have potential as implantable chips for nerve health diagnosis, neural prostheses, and brain-machine interfaces.

Keywords: anxiety disorders; neuromorphic computing; oxide neuromorphic transistors; proton coupling; synaptic plasticity.

PubMed Disclaimer

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More than 3.5 billion years ago, life on Earth emerged from chemical reactions. Nature invented RNA, proteins, and DNA, the core molecules of life, and created the ribosome, a molecular factory that builds proteins from instructions in the genome.

Proteins are wondrous dynamic molecules with incredible functions—from molecular engines that power motion, to photosynthetic machines that capture light and convert it to energy, scaffolding that builds the internal skeletons of cells, complex sensors that interact with the environment, and information processing systems that run the programs and operating system of life. Proteins underlie disease and health, and many life-saving medicines are proteins.

Biology is the most advanced technology that has ever been created, far beyond anything that people have engineered. The ribosome is programmable—it takes the codes of proteins in the form of RNA and builds them up from scratch—fabrication at the atomic scale. Every cell in every organism on earth has thousands to millions of these molecular factories. But even the most sophisticated computational tools created to date barely scratch the surface: biology is written in a language we don’t yet understand.

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Schizophrenia, a neurodevelopmental disorder that features psychosis among its symptoms, is thought to arise from disorganization in brain connectivity and functional integration. Now, a recent study in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, finds differences in functional brain connectivity in people with and without psychosis and schizophrenia that could help researchers understand the neural underpinnings of this disease.

The brain’s cortex is organized in a hierarchical fashion, anchored by the sensorimotor cortex at one end and by multimodal association areas at the other, with the task of integrating incoming sensory information with internal and external sensory signals. The loss of executive control in schizophrenia may stem from disruption of this hierarchical signaling.

Alexander Holmes, a Ph.D. candidate at Monash University who led the study, said, “We used brain imaging and novel mathematical techniques to investigate the hierarchical organization of the brains of individuals with early psychosis and established schizophrenia. This organization is important for brain health, as it regulates how we can effectively respond to and process stimuli from the external world.”

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Good health depends on a healthy diet and sufficient exercise and sleep. There are clear associations among these components; for example, good nutrition provides energy for exercise, and many people report that getting enough exercise is important to their ability to get enough sleep. So how might nutrition affect sleep?

A new study looks at the connection between fruit and vegetable intake and sleep duration. The research, by a team from Finland’s University of Helsinki, National Institute for Health and Welfare, and Turku University of Applied Sciences, is published in Frontiers in Nutrition.

Why sleep is important and how it works Sleep gives our bodies the chance to rest and recover from wakeful activity. Our hearts, blood vessels, muscles, cells, immune systems, cognitive abilities, and memory-making abilities depend on regular, healthy sleep for optimal functioning, and a 2019 study suggests that sleep is important for repairing DNA damage that occurs during wakefulness.

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Researchers are warning that geoengineering efforts to help cool temperatures in California could trigger heatwaves in Europe, a “scary” implication given the sheer lack of regulation controlling such measures across the globe.

As The Guardian reports, scientists have suggested spraying aerosols into clouds over the ocean to cool down the surface below, a practice called “marine cloud brightening.” As the name suggests, the idea is to brighten clouds to make them reflect more of the Sun’s radiation back into space.

Last month, a team of University of Washington researchers attempted to do just that in the San Francisco Bay using a machine that sprays tiny sea-salt particles, amid criticism from environmentalists. The experiment was later shut down by city officials, citing health concerns.

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Researchers at the University of Utah Health have discovered that “time cells” in mice are crucial for learning tasks where timing is critical. These cells change their firing patterns as mice learn to distinguish between timed events, suggesting a role beyond just measuring time. This finding could help in the early detection of neurodegenerative diseases like Alzheimer’s by highlighting the importance of the medial entorhinal cortex (MEC), which is among the first brain regions affected by such diseases.

Researchers at the University of Utah Health found that “time cells” in mice adapt to learning timed tasks, a discovery that could aid early Alzheimer’s detection by monitoring changes in a key brain region.

Our perception of time is crucial to our interaction with and understanding of the world around us. Whether we’re engaging in a conversation or driving a car, we need to remember and gauge the duration of events—a complex but largely unconscious calculation running constantly beneath the surface of our thoughts.

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