Physical exercise is great for a mouse’s brain, and for yours. Numerous studies conducted in mice, humans and laboratory glassware have made this clear. Now, a new study shows it’s possible to transfer the brain benefits enjoyed by marathon-running mice to their couch-potato peers.

Stanford School of Medicine researchers have shown that blood from young adult mice that are getting lots of exercise benefits the brains of same-aged, sedentary mice. A single protein in the blood of exercising mice seems largely responsible for that benefit.

The discovery could open the door to treatments that—by taming brain inflammation in people who don’t get much exercise—lower their risk of neurodegenerative disease or slow its progression.

What if the next global health crisis is a mental health pandemic? It is here now.

According to Gallup, anger, stress, worry and sadness have been on the rise globally for the past decade — long before the COVID-19 pandemic — and all reached record highs in 2020.

People die from COVID-19 — they also die from depression and anxiety disorders. The U.S. has seen spikes in deaths from suicide and “deaths of despair.”

Deaths of despair — a new designation made prominent by Princeton economists Anne Case and Nobel laureate Sir Angus Deaton in their book of the same name — are suicides and deaths caused by fatal behaviors such as drug overdoses and liver failure from chronic alcohol consumption. They have particularly harmed working-class males in the American heartland and increased dramatically since the mid-1990s, from about 65,000 in 1995 to 158,000 in 2018.

Think of deaths of despair as suicide in slow motion.

A silicon device that can change skin tissue into blood vessels and nerve cells has advanced from prototype to standardized fabrication, meaning it can now be made in a consistent, reproducible way. As reported in Nature Protocols, this work, developed by researchers at the Indiana University School of Medicine, takes the device one step closer to potential use as a treatment for people with a variety of health concerns.

The technology, called tissue nanotransfection, is a non-invasive nanochip device that can reprogram tissue function by applying a harmless electric spark to deliver specific genes in a fraction of a second. In laboratory studies, the device successfully converted skin tissue into blood vessels to repair a badly injured leg. The technology is currently being used to reprogram tissue for different kinds of therapies, such as repairing brain damage caused by stroke or preventing and reversing nerve damage caused by diabetes.