Lifeboat Foundation: Safeguarding Humanity
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Category: health – Page 19

Researchers at FutureNeuro, the SFI Research Centre for Translational Brain Science, and RCSI University of Medicine and Health Sciences, in collaboration with international partners, have developed a revolutionary technique to profile gene activity in the living human brain.

This innovative approach, published in JCI Insight, opens new avenues for understanding and treating neurological conditions like epilepsy.

Studying gene activity in the brain without requiring invasive tissue samples from surgery or post-mortem donation has been a long-standing challenge in neuroscience. By analyzing molecular traces – specifically RNA and DNA – collected from electrodes implanted in the brains of patients with epilepsy and linking these with electrical recordings from the brain, the researchers were able to take a ‘snapshot’ of gene activity in the living brain.

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Advancements in deep-tech solutions addressing global healthcare challenges.

The landscape of healthcare is undergoing a radical transformation fueled by deep-tech innovations that tackle some of the most pressing global health challenges. Deep-tech, a term that encompasses technologies grounded in scientific research and engineering advancements, is reshaping diagnostics, treatment modalities, and healthcare delivery systems on a global scale. With increasing demands for accessible, efficient, and equitable healthcare, deep-tech solutions—such as artificial intelligence (AI), advanced robotics, nanotechnology, biotechnology, and quantum computing—are playing pivotal roles in reshaping modern medicine.

This article explores the advancements in deep-tech solutions that are addressing global healthcare challenges and provides insight into how these technologies are likely to shape the future of medicine, impacting medical professionals, patients, and healthcare systems worldwide.

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Colorectal cancer (CRC) remains one of the most clinically challenging malignancies facing our public health system. CRC accounts for the second and third most common cancer in males and females, respectively. In addition, CRC represents one of the most deadly cancers, expected to result in over 50,000 mortalities in 2024.

Hereditary colorectal cancer (HCRC) occurs when a parent passes a cancer gene to a child. Unfortunately, we have not identified a single gene that causes the disease. Hereditary CRC syndromes, such as hereditary non-polyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and familial adenomatous polyposis (FAP), describe a group of genetic diseases that confer a high risk of developing CRC. As our knowledge has expanded, we have learned about a growing number of genetic variants in the genes that predispose carriers to CRC. However, the precise role of some variants in the development of CRC cancer remains unclear. Uncovering more information about these variants, called variants of uncertain significance.

As our knowledge has expanded, we have learned about a growing number of genetic variants in the genes which predispose carriers to CRC. However, the precise role of some variants in the development of CRC cancer remains unclear. Uncovering more information about these variants, called variants of uncertain significance (VUS), can aid in optimizing screening and surveillance programs.

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Viviana Gradinaru, an assistant professor of biology at Caltech, discovered her passion for neuroscience as an undergraduate at Caltech, her alma mater. Viviana did her Ph.D. work with Karl Deisseroth at Stanford University where she played an instrumental role in the early development and applications of optogenetics, a research area concerned with the perturbation of neuronal activity via light-controlled ion channels and pumps. More information on her own lab at Caltech can be found at glab.caltech.edu. Viviana is also interested in entrepreneurship for better human health and has co-founded a company, Circuit Therapeutics, based on optogenetics.

In the spirit of ideas worth spreading, TEDx is a program of local, self-organized events that bring people together to share a TED-like experience. At a TEDx event, TEDTalks video and live speakers combine to spark deep discussion and connection in a small group. These local, self-organized events are branded TEDx, where x = independently organized TED event. The TED Conference provides general guidance for the TEDx program, but individual TEDx events are self-organized.* (*Subject to certain rules and regulations)\ \ .

On January 18, 2013, Caltech hosted TEDxCaltech: The Brain, a forward-looking celebration of humankind’s quest to understand the brain, by exploring the past, present and future of neuroscience. Visit TEDxCaltech.com for more details.

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It’s no secret: when we savour a delicious piece of fish or a platter of seafood, we’re not just consuming valuable omega-3s and vitamin D. Alongside these benefits come less appetising elements – countless micro– and nano-plastics.

These plastic particles, measuring less than 5 millimetres, enter our oceans through human waste and penetrate the food chain. According to an Ifremer study, around 24,400 billion microplastics are floating on the ocean’s surface.

These particles are found in all marine organisms – from microalgae to fish, which occupy higher levels of the food chain. This phenomenon not only threatens marine ecosystems but also raises concerns about potential risks to human health.

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A quiet revolution is brewing in labs around the world, where scientists’ use of AI is growing exponentially. One in three postdocs now use large language models to help carry out literature reviews, coding, and editing. In October, the creators of our AlphaFold 2 system, Demis Hassabis and John Jumper became Nobel Laureates in Chemistry for using AI to predict the structure of proteins, alongside the scientist David Baker, for his work to design new proteins. Society will soon start to feel these benefits more direct ly, with drugs and materials designed with the help of AI currently making their way through development.

In this essay, we take a tour of how AI is transforming scientific disciplines from genomics to computer science to weather forecasting. Some scientists are training their own AI models, while others are fine-tuning existing AI models, or using these models’ predictions to accelerate their research. Scientists are using AI as a scientific instrument to help tackle important problems, such as designing proteins that bind more tightly to disease targets, but are also gradually transforming how science itself is practised.

There is a growing imperative behind scientists’ embrace of AI. In recent decades, scientists have continued to deliver consequential advances, from Covid-19 vaccines to renewable energy. But it takes an ever larger number of researchers to make these breakthroughs, and to transform them into downstream applications. As a result, even though the scientific workforce has grown significantly over the past half-century, rising more than seven fold in the US alone, the societal progress that we would expect to follow, has slowed. For instance, much of the world has witnessed a sustained slowdown in productivity growth that is undermining the quality of public services. Progress towards the 2030 Sustainable Development Goals, which capture the biggest challenges in health, the environment, and beyond, is stalling.

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The Quickest Route To Healthy

Linda Jiang is Head of Strategy and Government Partnerships, Healthcare, at Lyft (https://www.lyft.com/healthcare), where she’s responsible for accelerating the growth of the business, driving public sector strategy, and partnering with policymakers and regulators to bring access to the rideshare service to millions of people who need it for healthcare access.

Previously, Linda was an early growth operator at healthcare startups, leading strategy for Modern Fertility and consumer marketing for Color Genomics.

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To maintain a healthy immune system, doctors advise patients to take vitamins and minerals. Vitamins have many functions that benefit the body, including resisting infection, energy boost, aiding in blood clotting, improving brain function, generation of red blood cells, promoting a healthy gut microbiome, improving wound healing, preventing eye deterioration, and developing strong bones. We can get vitamins from various sources, including orange juice, which is rich in vitamin C, folate, and potassium. Physicians often recommend supplements for patients low on specific vitamins. However, dysregulation of vitamins can weaken the immune system and promote overall bad health. One vitamin in particular that helps maintain cellular function includes B12. This vitamin is essential to generate DNA and red blood cells, and aids in nerve function, energy conversion, and protein metabolism. When a patient has a B12 deficiency it can result in muscle weakness, numbness in hands and feet, difficulty walking, nausea, loss of appetite, and unintentional weight loss. In addition, it can allow the buildup of a small molecule known as methylmalonic acid (MMA).

In healthy tissues, vitamin B12 helps break down MMA. In B12 deficient patients, MMA is increased and can be measured through blood or urine samples. Methylmalonic acid is produced when proteins in your muscle, known as amino acids, are broken down. Tests to determine B12 deficiency or a genetic disorder are done by physicians at birth and after the appearance of symptoms related to B12 deficiency. Interestingly, a group of scientists have discovered a new deleterious role of MMA in lung carcinoma.

A recent publication from Oncogene, by Dr. Ana P. Gomes and others, demonstrated that MMA in aged patients weakens immune cell function and promotes lung cancer progression. Gomes is a professor of molecular oncology at Moffitt Cancer Center in Florida. Her work specifically focuses on understanding metabolic changes as we age and how this change in metabolism influences cancer risk.

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The Expedition 72 crew studied micro-algae and DNA-like nanomaterials on Tuesday to improve health in space and on Earth. The orbital residents also worked on cargo transfers and lab maintenance aboard the International Space Station.

NASA Flight Engineer Nick Hague began his day processing radiation-resistant samples of Arthrospira C micro-algae and stowing them in an incubator for analysis. The samples will be exposed to different light intensities to observe how they affect the micro-algae’s cell growth and oxygen production. Results may advance the development of spacecraft life support systems and fresh food production in space.

Afterward, Hague joined Commander Suni Williams of NASA for a different research session mixing water with samples of messenger RNA, or mRNA, and protein to create DNA-like nanomaterial products inside the Kibo laboratory module’s Life Science Glovebox. Flight Engineer Butch Wilmore then transferred the samples, exposed them to ultrasonic waves, and imaged them with a spectrophotometer to measure the intensity of light at different wavelengths and evaluate the quality of the nanomaterials. The samples will also be returned to Earth for further evaluation. Results may lead to improved therapies for Earth and space health conditions as well as advance the space economy.

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Researchers at Tokyo University of Science have developed a solar cell-based optoelectronic device that mimics human synapses for efficient edge AI processing.

Artificial intelligence (AI) is becoming increasingly useful for the prediction of emergency events such as heart attacks, natural disasters, and pipeline failures. This requires state-of-the-art technologies that can rapidly process data. In this regard, reservoir computing, specially designed for time-series data processing with low power consumption, is a promising option.

It can be implemented in various frameworks, among which physical reservoir computing (PRC) is the most popular. PRC with optoelectronic artificial synapses (junction structures that permit a nerve cell to transmit an electrical or chemical signal to another cell) that mimic human synaptic elements are expected to have unparalleled recognition and processing capabilities akin to the human visual system.

However, PRC based on existing self-powered optoelectronic synaptic devices cannot handle time-series data across multiple timescales, present in signals for monitoring infrastructure, natural environment, and health conditions.

Continue reading “Novel physical reservoir computing device mimics human synaptic behavior for efficient edge AI processing” | >