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Category: health – Page 16

Novartis receives approval for first malaria medicine for newborn babies and young infants

Basel, July 8, 2025 – Novartis today announced Coartem® (artemether-lumefantrine) Baby has been approved by Swissmedic as the first malaria medicine for newborns and young infants. The new treatment, also known as Riamet® Baby in some countries, was developed in collaboration with Medicines for Malaria Venture (MMV) to treat the potentially deadly mosquito-borne disease.

Eight African countries also participated in the assessment and are now expected to issue rapid approvals under the Swiss agency’s Marketing Authorization for Global Health Products procedure.1 Novartis plans to introduce the infant-friendly treatment on a largely not-for-profit basis to increase access in areas where malaria is endemic.

“For more than three decades, we have stayed the course in the fight against malaria, working relentlessly to deliver scientific breakthroughs where they are needed most,” said Vas Narasimhan, CEO of Novartis. “Together with our partners, we are proud to have gone further to develop the first clinically proven malaria treatment for newborns and young babies, ensuring even the smallest and most vulnerable can finally receive the care they deserve.”

Healthy lifestyle linked to lower diverticulitis risk, irrespective of genetic susceptibility

Maintaining a healthy lifestyle—specifically, a diet rich in fiber but light on red/processed meat, regular exercise, not smoking, and sticking to a normal weight—is linked to a significantly lower risk of diverticulitis, finds a large long-term study, published online in the journal Gut.

What’s more, these five components seem to offset the effects of inherited genes, the findings indicate.

Diverticulitis occurs when “pouches” develop along the gut and become inflamed or infected in the wall of the large intestine (colon), explain the researchers. It’s a common cause of hospital admissions and a major reason for emergency colon surgery, they add.

Danish trial reveals how structured exercise and guidance affect life with chronic conditions

A large multicenter trial found that a 12-week personalized exercise therapy and self-management support program produced a small but statistically significant improvement in health-related quality of life for adults with multimorbidity. The intervention was safe, but its clinical relevance remains uncertain, as only self-rated health showed a significant benefit over usual care.

Intelligent wound dressing controls inflammation

Chronic wounds are a major medical challenge, burdening health care systems with billions of dollars in costs every year. Pioneer Fellow Börte Emiroglu is developing a new product: a selective, sponge-like hydrogel that reduces inflammatory signals and actively promotes healing.

The work is published in the journal Advanced Healthcare Materials.

Emiroglu’s academic career has taken her from Turkey to Zurich, after a master’s degree, and straight into the interdisciplinary world of biomedical engineering at ETH Zurich. “Back then, I didn’t even know what a hydrogel was,” she recalls, thinking back to the early days of her doctoral research at the Macromolecular Engineering Laboratory under the supervision of Professor Mark Tibbitt.

Alveolar macrophage cell surface receptor TREM2 promotes lung fibrosis, study shows

Lung macrophages play a pivotal role in diseases like idiopathic pulmonary fibrosis. Two types of macrophages—the white blood cells that defend the body by killing microbes, removing dead cells and stimulating immune responses—are found in the lung. They are tissue resident macrophages, which are present from birth, and monocyte-derived macrophages that enter the lungs for a short time in response to damage or infection.

Recently these monocyte-derived , or Mo-AMs, were identified as key drivers of lung fibrosis disease progression. However, the mechanisms of their pro-fibrotic behavior and survival in the lungs remained unclear, so clinicians continue to lack effective therapies.

In a study published in the journal Nature Communications, Gang Liu, M.D., Ph.D., Huachun Cui, Ph.D., and their University of Alabama at Birmingham colleagues show that TREM2, a cell surface receptor protein on Mo-AM cells, is a critical regulator of macrophage-mediated lung fibrosis. This makes it a promising therapeutic target for intervention, says Gang, a professor in the UAB Department of Medicine Division of Pulmonary, Allergy and Critical Care Medicine.

ReSURF: Stretchable, self-healing water quality sensor enables ultrafast surveillance

Clean, safe water is vital for human health and well-being. It also plays a critical role in our food security, supports high-tech industries, and enables sustainable urbanization. However, detecting contamination quickly and accurately remains a major challenge in many parts of the world.

A new device developed by researchers at the National University of Singapore (NUS) has the potential to significantly advance water quality monitoring and management.

Taking inspiration from the biological function of the oily protective layer found on , a team of researchers led by Associate Professor Benjamin Tee from the Department of Materials Science and Engineering in the College of Design and Engineering at NUS translated this concept into a versatile material, named ReSURF, capable of spontaneously forming a water-repellent interface.

AI and biophysics unite to forecast high-risk viral variants before outbreaks

When the first reports of a new COVID-19 variant emerge, scientists worldwide scramble to answer a critical question: Will this new strain be more contagious or more severe than its predecessors? By the time answers arrive, it’s frequently too late to inform immediate public policy decisions or adjust vaccine strategies, costing public health officials valuable time, effort, and resources.

In a pair of recent publications in Proceedings of the National Academy of Sciences, a research team in the Department of Chemistry and Chemical Biology combined biophysics with artificial intelligence to identify high-risk viral variants in record time—offering a transformative approach for handling pandemics. Their goal: to get ahead of a virus by forecasting its evolutionary leaps before it threatens public health.

“As a society, we are often very unprepared for the emergence of new viruses and pandemics, so our lab has been working on ways to be more proactive,” said senior author Eugene Shakhnovich, Roy G. Gordon Professor of Chemistry. “We used fundamental principles of physics and chemistry to develop a multiscale model to predict the course of evolution of a particular variant and to predict which variants will become dominant in populations.”

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