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Ultimately, the goal is to find ways to stop deadly disease caused by Cryptococcus neoformans from developing in humans and animals. But until that time, finding new and better ways to treat already existent disease and its symptoms is a high priority.

The laboratory of Kirsten Nielsen in the Center for One Health Research has taken a step toward improved treatment of Cryptococcus, completing a six-year study to examine the virulence of 38 clinical isolates from various strains of Cryptococcus. The results are published in Nature Communications.

“The question that we’ve been addressing is: Can we predict severe disease outcomes in patients?” said Nielsen, professor of microbiology and immunology in the Virginia-Maryland College of Veterinary Medicine. “If we can predict disease outcome, then we can treat patients better. In these studies, we identified not just the genes that allow Cryptococcus to cause disease, but also the gene alleles that allow it to cause more disease or less disease.”

Delivering Innovative, Compassionate And Accessible Patient Care — Robert Stone, CEO — City of Hope & Dr. Marcel van den Brink, MD, PhD, President, City of Hope Comprehensive Cancer Center.


Robert Stone is the CEO of City of Hope (https://www.cityofhope.org/robert-stone), a premier cancer research and treatment center dedicated to innovation in biomedical science and the delivery of compassionate, world-class patient care. A seasoned health care executive, he has served in a number of strategic decision-making roles since he joined City of Hope in 1996, culminating with his appointment as president in 2012, CEO in 2014, and as the Helen and Morgan Chu Chief Executive Officer Distinguished Chair in 2021.

Mr. Stone has J.D., University of Chicago Law School, Chicago, IL.

A new UC Davis Health study has uncovered how Salmonella bacteria, a major cause of food poisoning, can invade the gut even when protective bacteria are present. The research, published in the Proceedings of the National Academy of Sciences, explains how the pathogen tricks the gut environment to escape the body’s natural defenses.

The digestive system is home to trillions of bacteria, many of which produce short-chain fatty acids (SCFAs) that help fight harmful pathogens. But Salmonella manages to grow and spread in the gut, even though these protective compounds are present. The study asks: How does Salmonella get around this defense?

“We knew that Salmonella invades the small intestine, although it is not its primary site of replication. The colon is,” said the lead author of the study Andreas Bäumler is a UC Davis distinguished professor and vice chair of research in the Department of Medical Microbiology and Immunology.

Summary: New research reveals that the cognitive boost from moderate to vigorous exercise lasts up to the next day, enhancing memory performance in adults aged 50 to 83. The study also found that adequate sleep—particularly deep, slow-wave sleep—adds to these benefits.

Conversely, prolonged sedentary time was linked to poorer working memory the following day. These findings highlight the importance of daily physical activity and quality sleep for maintaining cognitive health, especially in older adults.

Synchron has developed a Brain-Computer Interface that uses pre-existing technologies such as the stent and catheter to allow insertion into the brain without the need for open brain surgery.

Read the CNET article for more info:
You Might Not Need Open Brain Surgery to Get Mind Control https://cnet.co/3sZ7k67

0:00 Intro.
0:25 History of Brain Chip Implants.
0:44 About Synchron.
0:54 How Synchron implants the interface.
1:55 How brain patterns transmit signals.
2:50 Risks and Concerns.
3:50 Patients and Clinical Testing.
4:25 Brain Health Monitoring.
5:04 Synchron Switch Price.

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Bacancy is proud to announce the launch of a new AI tool, MedPreGPT, to help doctors with medicine prescriptions. This system enables doctors who all are using it for internal purposes to give accurate prescription recommendations privately without wasting any time. Compared to AI models like ChatGPT, this tool is specially trained with vast medical data and makes relevant suggestions. This innovative tool is made to enhance patient care, reduce human errors, and streamline the prescription process.

Doctors are only humans and they indeed work under intense work pressure and workload. Mistakes can happen in such an environment. Today’s healthcare providers use ChatGPT and Google’s Gemini for medicine recommendations, which is not completely wrong, but those tools might give false information. Bacancy has recognized the problem and found MedPreGPT to give accurate medical prescriptions.

The following are features of MedPreGPT Provides AI-based prescription recommendations according to symptoms and history. It is integrated with electronic health records (EHRs) for workflow ease. It provides multilingual support for healthcare professionals across the world Provides healthcare providers with updates in real time, regarding the latest clinical guidelines and drug interactions to ensure true care.

Chatbots can wear a lot of proverbial hats: dictionary, therapist, poet, all-knowing friend. The artificial intelligence models that power these systems appear exceptionally skilled and efficient at providing answers, clarifying concepts, and distilling information. But to establish trustworthiness of content generated by such models, how can we really know if a particular statement is factual, a hallucination, or just a plain misunderstanding?

In many cases, AI systems gather external information to use as context when answering a particular query. For example, to answer a question about a medical condition, the system might reference recent research papers on the topic. Even with this relevant context, models can make mistakes with what feels like high doses of confidence. When a model errs, how can we track that specific piece of information from the context it relied on — or lack thereof?

To help tackle this obstacle, MIT Computer Science and Artificial Intelligence Laboratory (CSAIL) researchers created ContextCite, a tool that can identify the parts of external context used to generate any particular statement, improving trust by helping users easily verify the statement.


The ContextCite tool from MIT CSAIL can find the parts of external context that a language model used to generate a statement. Users can easily verify the model’s response, making the tool useful in fields like health care, law, and education.

New research suggests Alzheimer’s drugs may improve cognition by increasing Aβ42 levels rather than just reducing plaques, challenging the amyloid cascade hypothesis and pointing to new therapeutic strategies focused on restoring soluble Aβ42 to maintain brain health.

All DNA is prone to fragmentation, whether it is derived from a biological matrix or created during gene synthesis; thus, any DNA sample will contain a range of fragment sizes. To really exploit the true benefits of long read sequencing, it is necessary to remove these shorter fragments, which might other wise be sequenced preferentially.

DNA size selection can exclude short fragments, maximizing data yields by ensuring that those fragments with the most informational content are not blocked from accessing detection centers (for example, ZMWs) by shorter DNA fragments.

Next-generation size-selection solutions Starting with clean, appropriate-length fragments for HiFi reads can accelerate research by reducing the computation and data processing time needed post-sequencing. Ranger Technology from Yourgene Health is a patent-protected process for automating electrophoresis-based DNA analysis and size selection. Its fluorescence machine vision system and image analysis algorithms provide real-time interpretation of the DNA separation process.