Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: genetics – Page 525

Surprising study shows reduced neuronal activity extends life

Say this about the kinds of molecular mayhem that we know underlie aging: Mechanisms like whether the ends of chromosomes fray (bad) and whether genes’ on-off status breaks down (really bad) at least sound like plausible ways to impair vital organs, from skin to brains and hearts, and produce the whole sorry mess known as aging.

On Wednesday, scientists reported a driver of aging that, in contrast, even the lead researcher diplomatically calls “counterintuitive”: neuronal activity. Aging, of course, affects the brain. But the brain seems to affect aging, too, they found: In creatures from worms to mice to people, high levels of neuronal firing spell a shorter life span. Lower levels — naturally, or due to drugs that dampen neurons’ activity — increase longevity.

The discovery4 was so surprising that it’s taken two years to be published (in Nature) because of how much additional data the outside scientists reviewing the study requested. Geneticist Bruce Yankner of Harvard Medical School, who led the research, understood their skepticism. “If you say you have a cat in your backyard, people believe you,” he said. “If you say you have a zebra, they want more evidence.”

A Mythical Form of Space Propulsion Finally Gets a Real Test

This does work it essentially is a very powerful microwave oven but it uses the exotic transfer of energy to propel an object. Plasma-based fusion reactors could power it indefinitely as well essentially it just be able to float out of the atmosphere. When it comes to more euclidean geometry or even like curl-free quantum mechanics for essentially space warping I think you could make warp drive with less energy just essentially slip through the ocean of space that is how black holes do it but they do it with gravity wells. I think if a genetic material could do similar things that are how essentially extraterrestrials do it as well it is more just a simple understanding of physics essentially. If the fabled q continuum exists it be essentially the realm of aliens because essentially it allows for travel through the universe without a ship. In fictional stories nightcrawler, a teleporting being was rumored. I think teleportation does exist as it is a qutrit but it is hard understanding travel instantaneously although I think some agencies rumor about it. If we can essentially teleport a photon we can teleport a human being even without a ship it would just require exotic physics and advanced biology. Essentially a portal gun from the Higgs boson could essentially make a physical transfer from one part to another part but it is hard to keep such things stable also there is a problem possibly of radiation you would probably need a suit to travel through a portal. Essentially it could work it just essentially be a wormhole from one point to another point but making that on the skin is essentially too hard unless you understand the properties of wormhole travel better by spaceship it would be easier. Essentially if you knew the physical space-time point by scanning an area you could essentially make a wormhole to that point and travel there. But doing that with genetics is harder as you need exotic properties or a better understanding of essentially of slipping through one place and coming out another.

Scientists have debated for decades whether the propulsion concept known as EmDrive is real or wishful thinking. A sensitive new tool may at last provide an answer.

Genetic differences in the immune system shape the microbiome

Genetic differences in the immune system shape the collections of bacteria that colonize the digestive system, according to new research by scientists at the University of Chicago.

In carefully controlled experiments using populated with microbes from conventionally raised mice, the researchers showed that while the makeup of the microbial input largely determined the resulting of the recipients, between strains of mice played a role as well.

“When the input is standardized, you can compare mice of different genetic strains and see what these genetics do to the microbiome in recipient mice,” said microbiome researcher Alexander Chervonsky, MD, Ph.D., a senior author of the new study, published in Cell Reports. “This approach allowed us to tell whether there was a genetic influence, and indeed there is. So, the next question was what mechanisms are involved?”

Crispr’s Next Frontier Is In-Human Treatment, Co-Inventor Says

As investors await results from the first U.S. clinical trials of the gene-editing system known as Crispr, scientists are focused on finding ways to administer it directly into humans, according to the technology’s co-inventor, Jennifer Doudna.

Right now, in studies using Crispr that have treated patients, researchers have had to extract their cells to be able to make edits to faulty DNA before infusing them back into the body for treatment. Being able to do precise edits directly inside humans, animals or plants could open the door to new applications, Doudna said.

Researchers obtain the first mice born with hyper-long telomeres

A chance finding 10 years ago led to the creation by researchers of the Spanish National Cancer Research Centre (CNIO) of the first mice born with much longer telomeres than normal in their species. Telomeres shorten throughout life, so older organisms have shorter telomeres. Given this relationship between telomeres and aging, the scientists launched a study generating mice in which 100 percent of their cells had hyper-long telomeres. The findings are published in Nature Communications and show only positive consequences: The animals with hyper-long telomeres live longer and in better health, free from cancer and obesity. This marks the first time that longevity has been significantly increased without any genetic modification.

“This finding supports the idea that, when it comes to determining longevity, genes are not the only thing to consider,” says Maria Blasco, head of the CNIO Telomeres and Telomerase Group and intellectual author of the paper. “There is margin for extending life without altering the genes.”

Telomeres form the ends of chromosomes in the nucleus of each cell in the body. Their function is to protect the integrity of the genetic information in DNA. Whenever the cells divide the telomeres, they are slightly shortened, so one of the main characteristics of aging is the accumulation of in cells. “Telomere shortening is considered to be one of the primary causes of aging, given that short telomeres cause aging of the organism and reduce longevity,” the authors write in a paper published in Nature Communications.

/* */