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Category: genetics – Page 523

Harvard’s David Sinclair Treats Aging as a Disease and Plans to Launch a Clinical Trial to Prove It

Harvard University’s David Sinclair, world renowned for his anti-aging research, sees no limit on human life span and is collaborating on a clinical trial to evaluate the effectiveness of a new drug aimed at slowing the aging process…

“There is no maximum human life span,” says Sinclair, Ph.D., who is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. “Anyone who says that doesn’t know what they are talking about.”

Sinclair hopes to demonstrate what he has been researching, – and talking about, for the past 20 years – that aging is a disease, which can be treated.

Tiny Light-Activated Gold-Covered Nanowires Can Make Neurons Fire

Researchers at the University of Chicago have developed light-activated nanowires that can stimulate neurons to fire when they are exposed to light. The researchers hope that the nanowires could help in understanding complex brain circuitry, and they may also be useful in treating brain disorders.

Optogenetics, which involves genetically modifying neurons so that they are sensitive to a light stimulus, has attracted a lot of attention as a research tool and potential therapeutic approach. However, some researchers have misgivings about optogenetics, as it involves inserting a gene into cells, potentially opening the door to unforeseen effects and possibly permanently altering treated cells.

In an effort to develop an alternative, a research team at the University of Chicago has devised a new modality that can enable light activation of neurons without the need for genetic modification. Their technique involves nanowires that are so small that if they were laid side-by-side, hundreds of them would fit on the edge of a sheet of paper. Although initially designed for use in solar cells, their small size also makes them well suited to interacting with cells.

MIT predicts 10 breakthrough technologies of 2018

The MIT Technology Review has released a list of technologies it believes will make the most impact over the next 12 months, including smarter cities, genetic fortune telling and “babel fish” earphones.

The Massachusetts Institute of Technology’s magazine has published the annual list online in its March/April 2018 issue, and based its contents on the innovations that will shape the coming year.

“What Tech Review looks for when selecting the list is to identify what will have a profound effect on our lives,” said a statement from the institution, based in Cambridge, Massachusetts.

In living color: Brightly-colored bacteria could be used to ‘grow’ paints and coatings

Researchers have unlocked the genetic code behind some of the brightest and most vibrant colours in nature. The paper, published in the journal PNAS, is the first study of the genetics of structural colour — as seen in butterfly wings and peacock feathers — and paves the way for genetic research in a variety of structurally coloured organisms.

The study is a collaboration between the University of Cambridge and Dutch company Hoekmine BV and shows how genetics can change the colour, and appearance, of certain types of brightly-coloured . The results open up the possibility of harvesting these bacteria for the large-scale manufacturing of nanostructured materials: biodegradable, non-toxic paints could be ‘grown’ and not made, for example.

Flavobacterium is a type of bacteria that packs together in colonies that produce striking metallic colours, which come not from pigments, but from their internal structure, which reflects light at certain wavelengths. Scientists are still puzzled as to how these intricate structures are genetically engineered by nature, however.

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