Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: genetics – Page 512

A new breakthrough spares certain breast cancer patients from chemotherapy

A new class of patients could soon be treated for breast cancer, no chemotherapy required. That’s because they don’t really benefit from it, according to a study published Sunday in the New England Journal of Medicine.

Those patients: those diagnosed with early-stage, invasive, hormone-receptor-positive breast cancer who scored in a specific range of a genetic test. They benefit just as much from chemotherapy, which many don’t tolerate well and can have long-term consequences, as they do from hormone treatments, which have many fewer side effects.

But before this study came out, many people in this group were prescribed chemotherapy because doctors had, based on the best information available, assumed it would help them. For those people, the side effects of chemotherapy could have been avoided, without making the treatment any less effective.

NAD+ Precursor Has Therapeutic Potential Against Parkinsons Disease

Today, we will be taking a look at a new study showing that an NAD+ precursor was able to improve mitochondrial function in cells and flies with a model of Parkinson’s disease.

Summary

While mitochondrial dysfunction is emerging as key in Parkinson’s disease (PD), a central question remains whether mitochondria are actual disease drivers and whether boosting mitochondrial biogenesis and function ameliorates pathology. We address these questions using patient-derived induced pluripotent stem cells and Drosophila models of GBA-related PD (GBA-PD), the most common PD genetic risk. Patient neurons display stress responses, mitochondrial demise, and changes in NAD+ metabolism. NAD+ precursors have been proposed to ameliorate agerelated metabolic decline and disease. We report that increasing NAD+ via the NAD+ precursor nicotinamide riboside (NR) significantly ameliorates mitochondrial function in patient neurons. Human neurons require nicotinamide phosphoribosyltransferase (NAMPT) to maintain the NAD+ pool and utilize NRK1 to synthesize NAD+ from NAD+ precursors. Remarkably, NR prevents the age-related dopaminergic neuronal loss and motor decline in fly models of GBA-PD.

Kidney cancer spreads

By Andy Coghlan

Many people with cancer die not from their original tumour, but from secondary tumours that grow elsewhere around the body. Now we’re a step closer to understanding how cancers are able to spread.

Sakari Vanharanta of the Medical Research Council Cancer Unit at the University of Cambridge and his colleagues have been studying kidney cancer cells. They found that to spread, these cells tap into the same genetic “travel” machinery normally used by healthy white blood cells to roam around the body.

Genomic Approach to Understand the Association of DNA Repair with Longevity and Healthy Aging Using Genomic Databases of Oldest-Old Population

Aged population is increasing worldwide due to the aging process that is inevitable. Accordingly, longevity and healthy aging have been spotlighted to promote social contribution of aged population. Many studies in the past few decades have reported the process of aging and longevity, emphasizing the importance of maintaining genomic stability in exceptionally long-lived population. Underlying reason of longevity remains unclear due to its complexity involving multiple factors. With advances in sequencing technology and human genome-associated approaches, studies based on population-based genomic studies are increasing. In this review, we summarize recent longevity and healthy aging studies of human population focusing on DNA repair as a major factor in maintaining genome integrity. To keep pace with recent growth in genomic research, aging- and longevity-associated genomic databases are also briefly introduced. To suggest novel approaches to investigate longevity-associated genetic variants related to DNA repair using genomic databases, gene set analysis was conducted, focusing on DNA repair- and longevity-associated genes. Their biological networks were additionally analyzed to grasp major factors containing genetic variants of human longevity and healthy aging in DNA repair mechanisms. In summary, this review emphasizes DNA repair activity in human longevity and suggests approach to conduct DNA repair-associated genomic study on human healthy aging.

Aging is an inevitable process in human life. Many countries are rapidly transitioning to an aging society due to increasing life expectancy and advanced medical supports [1–3]. Over the last few decades, the advent of aging society is considered a crucial issue that may cause future decline in productivity of community [1, 4]. Many researchers have recently warned that urban environmental pollutants can cause physiological weakness and increase the risk of premature aging or chronic diseases in the elderly population [5–9]. Thus, interest in antiaging and healthy longevity is constantly increasing. “Active aging” or “successful aging” has been spotlighted as a strategy to promote social contribution of the elderly [10]. The definition of successful aging remains controversial.

Can You Actually Hack Your DNA to Slow Down Aging? — Bioquark Inc. — Ira Pastor

http://www.thepathmag.com/can-you-actually-hack-your-dna-to-slow-down-aging/

Many technologies / interventions progressing down the development pathways in the coming years — but there are a lot of free, common sense adjustments you can make today:

Best of last week: Flux capacitor invented, a better 3D printer and the true benefits of vitamins

It was a good week for physics as a team with members from Australia and Switzerland invented a flux capacitor able to break time-reversal symmetry. They proposed a device based on quantum tunneling of magnetic flux around a capacitor. And another team with members from across the U.S. reported on a gravitational wave event that likely signaled the creation of a black hole—the merger of two neutron stars.

In biology news, a team of engineers led by Sinisa Vukelic invented a noninvasive technique to correct vision. Like LASIK, it uses lasers but is non-surgical and has few side-effects. And an international team of researchers found what they describe as the mother of all lizards in the Italian Alps, the oldest known lizard fossil, from approximately 240 million years ago. Also, a team at the University of Sydney found that walking faster could make you live longer. People do not even need to walk more, the team reported, they just need to pick up the pace of their normal stride to see an improvement in several health factors. And a team from Cal Poly Pomona discovered how microbes survive clean rooms and contaminate spacecraft—and it involved the cleaning agents themselves.

In other news, a team of researchers from the University of California and the University of Southern Queensland announced that they had identified 121 giant planets that may have habitable moons. And a team at Stanford University found that wars and clan structure might explain a strange biological event that occurred 7,000 years ago—male genetic diversity appeared to collapse for a time. Also, a team of researchers from MIT and Harvard University report the development of a 3D printer that can print data sets as physical objects—offering far more realistic, nearly true-color renderings.

8 Amazing CRISPR projects that could change life as we know it

8 Amazing CRISPR gene editing projects that could change life as we know it.

Since it burst onto the scene a decade ago, CRISPR-Cas9 has shaken the field of genetics to its core. Offering a new genomic editing tool that’s faster, cheaper and more accurate than previous approaches, it opens up an astonishing breadth of possible applications.

From saving lives to potentially rescuing coral reefs, here are eight examples of exciting CRISPR projects that showcase just why this gene-editing tech has everyone talking.

CRISPR-edited rice plants increase grain yield

Scientists from Purdue University and the Chinese Academy of Sciences report the use of CRISPR/Cas9 to develop a variety of rice producing 25–31% more grain than traditional breeding methods.

crispr future technology

The team, led by Jian-Kang Zhu, a distinguished professor in the Department of Horticulture and Landscape Architecture at Purdue and director of the Shanghai Center for Plant Stress Biology at the Chinese Academy of Sciences, made mutations to 13 genes associated with the plant hormone abscisic acid – known to play roles in plant stress tolerance and suppression of growth. Of several varieties created, one produced a plant that had little change in stress tolerance but produced 25% more grain in a field test in Shanghai, China, and 31% more in a field test conducted on China’s Hainan Island.

/* */