The only thing we know for sure is that everything will change.
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Category: genetics – Page 510
Crohn’s Disease is a legendarily difficult disease to not only identify but to treat or cure. The disease affects the intestines and digestive tract, stemming from bacteria in those areas building up and leading to serious side effects. It affects more than half a million people in the United States and is brutal – with the possibility of diarrhea, weight loss, fatigue, ulcers, malnutrition, and eventually colon cancer, liver disease or osteoporosis.
Treatment is limited, with the current best options being medicine to limit inflammation and prevent symptoms. There is no complete cure, only efforts to make life as comfortable and normal as possible for those afflicted. Without a specific target at which to aim some sort of treatment, the options for permanently reducing or removing symptoms and health risks are few and far between. Before now, the only thing scientists thought they knew about the disease’s cause was that E Coli was involved.
However, recent studies have led researches to believe that they have narrowed down other bacteria that contributes to the onset and ongoing symptoms of Crohn’s. Experts at the Center for Medical Mycology at Case Western Reserve and University Hospitals Cleveland Medical Center (wow, is that a mouthful!) think they have pinpointed two additional bacterial strains that contribute to the disease. They studied a cross section of people – those with the disease, those with the disease whose family members did not have it, and those without it – to attempt to identify common details in their biological tests. Such a diverse group of subjects is required not only due to the importance of adhering to the scientific method but because Crohn’s can be caused by genetics and environmental factors.
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In a world first, a baby has been born with DNA from three biological parents.
Five-month-old Abrahim Hassan’s Jordanian parents, Ibtisam Shaban and Mahmoud Hassan, were treated by a U.S. team based in Mexico using a controversial technique that allows parents with rare genetic mutations to have healthy babies, the New Scientist reports.
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When a malignant tumor invades the body, immune cells rush to the site to begin to fight it. When that same tumor spreads throughout the body, however, the cancer cells become invisible to our immune systems and can metastasize unencumbered by our natural defenses. Researchers out of the University of British Columbia (UBC) are on to cancer’s tricky cloaking mechanism though, and their discovery could lead to new approaches to attacking the disease.
“We discovered a new mechanism that explains how metastatic tumours can outsmart the immune system and we have begun to reverse this process so tumours are revealed to the immune system once again,” said Wilfred Jefferies, senior author of a new study in Scientific Reports and a professor of medical genetics and microbiology and immunology at UBC.
The discovery hinges on a protein called interleukein-33, or IL-33 that’s present in primary tumors. When the tumors emit this protein, it causes another protein complex known as the major histocompatibility complex (MHC) to activate, which tags the cancer cells as a bad presence in the body and guides the immune system to get to work destroying them.
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Yesterday, in the New York Review of Books, Freeman Dyson analyzed a trio of recent books on humanity’s future in the larger cosmos. They were How to Make a Spaceship: A Band of Renegades, an Epic Space Race, and the Birth of Private Spaceflight; Beyond Earth: Our Path to a New Home in the Planets; and All These Worlds Are Yours: The Scientific Search for Alien Life.
Dyson is “a brilliant physicist and contrarian,” as the theoretical astrophysicist Lawrence Krauss recently told Nautilus. So I was waiting, as I read his review, to come across his profound and provocative pronouncement about these books, and it came soon enough: “None of them looks at space as a transforming force in the destiny of our species,” he writes. The books are limited in scope by looking at the future of space as a problem of engineering. Dyson has a grander vision. Future humans can seed remote environments with genetic instructions for countless new species. “The purpose is no longer to explore space with unmanned or manned missions, but to expand the domain of life from one small planet to the universe.”
Dyson can be just as final in his opinions on the destiny of scientific investigation. According to Krauss, Dyson once told him, “There’s no way we’re ever going to measure gravitons”—the supposed quantum particles underlying gravitational forces—“because there’s no terrestrial experiment that could ever measure a single graviton.” Dyson told Krauss that, in order to measure one, “you’d have to make the experiment so massive that it would actually collapse to form a black hole before you could make the measurement.” So, Dyson concluded, “There’s no way that we’ll know whether gravity is a quantum theory.”
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ETH researchers are developing tiny, sophisticated technological and biological machines enabling non-invasive, selective therapies. Their creations include genetically modified cells that can be activated via brain waves, and swarms of microrobots that facilitate highly precise application of drugs.
Richard Fleischner, who directed the 1966 cult film Fantastic Voyage, would have been delighted with Bradley Nelson’s research: similar to the story in Fleischner’s film, Nelson wants to load tiny robots with drugs and manoeuvre them to the precise location in the human body where treatment is needed, for instance to the site of a cancer tumour. Alternatively, the tiny creatures could also be fitted with instruments, allowing operations to be performed without surgical intervention. The advantages compared with conventional treatments with drugs are clear: far more targeted therapy, and as a result, fewer side effects.
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Microsoft has announced to solve’ cancer within the next decade by ‘reprogramming’ diseased cells like computer virus.
Researchers were able to prevent the death of neurons that causes ALS by introducing a genetic mutation to prevent the SOD1 protein from clumping.
The growing resistance of Gonorrhea, alarmed the researchers.
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In a recent experiment, a Swedish scientist, Fredrik Lanner, a developmental biologist at the Karolinska Institute in Stockholm, attempted to modify the genes of a human embryos injecting a gene-editing tool known as CRISPR-Cas9 into carefully thawed five human embryos donated by couples who had gone through in vitro fertilization (IVF). One did not survive the cooling and thawing process, while another one was severely damaged while being injected. The remaining three embryos, which were two-days old when they were injected, survived in good shape, with one of them dividing immediately after being injected.
Scientists have viewed modifying a human embryo as over the line for safety and ethical concerns. The fear is that Lanner’s work could open the door to others attempting to use genetically modified embryos to make babies. One mistake could introduce a new disease in the human gene pool that can be inherited by future generations. Scientists are also concerned on the possibility of “designer babies,” where parents could choose traits they want for their babies.
Fredrik Lanner (right) of the Karolinska Institute in Stockholm and his student Alvaro Plaza Reyes examine a magnified image of an human embryo that they used to attempt to create genetically modified healthy human embryos. (Credit: Rob Stein/NPR)
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