#Interesting #opinion This was brought up a decade ago, yet he was never asked to alter his genetics to make it fair for others. Is the current case one of discrimination? The recent work on the Chinese CRISPER babies showed that it augmented their ability. Will CRISPER babies also have in the future to “Change Their Genetics” to compete in sports if deemed unfair advantage?
It turns out the capacity for offspring to benefit from their parents’ experiences doesn’t just happen with fish. Munday tells me about Daphnia, often called water fleas, that are found in freshwater lakes, ponds, and puddles. The tiny crustacean can hatch with either a round head or a pointed head. If it shares the water with predators such as fish or midges or other insects, spikes and spines help lessen the likelihood of being eaten. For many species of juvenile water flea…
Insights into epigenetics and inheritance show that some organisms can adapt to a changing world.
The lionfish is an invasive species that is currently wreaking havoc in the warm waters of the Bahamas, the Caribbean, and the US southwestern Atlantic and Gulf of Mexico coasts. But where did they come from and what makes this normally docile hunter suddenly turn vicious in its new home? To answer these questions, North Carolina State University initiated a study of lionfish genetics to learn more about their origins and how to control them.
Without ensuring high levels of accuracy, any proposed CRISPR gene therapy becomes a genetic crapshoot.
Now, a team from Duke University may have found a universal workaround—a trick to fundamentally boost CRISPR’s accuracy in almost all its forms. Published this month in Nature Biotechnology, the team’s study tweaked the design of guide RNAs, the indispensable targeting “blood hound” of the CRISPR duo that hunts down specific DNA sequences before its partner Cas makes the cut.
The upgrade is deceptively simple: tag a “locking” structure to one end of the guide RNA so that only the targeted DNA can unleash the power of the Cas scissors. Yet exactly because the tweak is so easy, guide RNA 2.0 can fundamentally tune the accuracy of multiple CRISPR systems—not just those relying on the classic Cas9, but also newer diagnostic systems that deploy Cas12a and other flavors—by as much as 200-fold.
