Check out the science of biohacking, where biologists go into a patient’s genetic code and reprogram their immune system to recognize and fight cancer cells.
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The human body is made up of about 30 trillion cells that carry a code which has been duplicated over and over for billions of years — with varying degrees of accuracy. So what happens when the system breaks down and the machinery turns on itself, leading to cancer? Greg Foot dives into the science of how biologists are biohacking the human body to try to fix the seemingly unfixable.
Lesson by Greg Foot, directed by Pierangelo Pirak.
What interesting trends are we seeing in genetics research right now? originally appeared on Quora: the place to gain and share knowledge, empowering people to learn from others and better understand the world.
Answer by Carrie Northover, Research Director at 23andMe, on Quora:
One of the coolest things right now is the size and scale of the research we’re able to do with human genetics, and those numbers are just getting bigger and bigger.
Cell-by-cell genetic analyses of developing brain tissues in neonatal mice and laboratory models of brain cancer allowed scientists to discover a molecular driver of the highly aggressive, deadly, and treatment-resistant brain cancer, glioblastoma.
Published findings in Cell Stem Cell describe how the single-cell analyses identified a subpopulation of cells critical to glioblastoma formation—the early primitive progenitor cells of oligodendrocyte brain cells, pri-OPC progenitors, according to Q. Richard Lu, Ph.D., lead investigator and Scientific Director of the Brain Tumor Center at Cincinnati Children’s Hospital Medical Center.
The data suggest that reprogramming of primitive oligodendrocyte progenitors into a stem-like state plays an important role in glioma initiation and progression. The researchers’ primary molecular target in the study, a protein called Zfp36l1, launches biological programs that mirror those of healthy early brain development in the mice, but instead help fuel brain cancer growth. The discovery presents an opportunity to find out if new therapeutic approaches can stop glioblastoma at its earliest stages of initial formation or recurrence, Lu said.
As a genetic material, DNA is responsible for all known life. But DNA is also a polymer. Tapping into the unique nature of the molecule, Cornell engineers have created simple machines constructed of biomaterials with properties of living things.
Using what they call DASH (DNA-based Assembly and Synthesis of Hierarchical) materials, Cornell engineers constructed a DNA material with capabilities of metabolism, in addition to self-assembly and organization – three key traits of life.
“We are introducing a brand-new, lifelike material concept powered by its very own artificial metabolism. We are not making something that’s alive, but we are creating materials that are much more lifelike than have ever been seen before,” said Dan Luo, professor of biological and environmental engineering in the College of Agriculture and Life Sciences.
But not everyone is on board.
“The use of transgenic monkeys to study human genes linked to brain evolution is a very risky road to take,” University of Colorado geneticist James Sikela told the MIT Technology Review. “It is a classic slippery slope issue and one that we can expect to recur as this type of research is pursued.”
Pinpointing the gene’s role in intelligence could help scientists understand how humans evolved to be so smart, MIT Tech reports.
“Ruby, along with her company Applied Stem Cell, is one of the world’s most respected experts in gene editing. We are delighted to be working with her on our ambitious project to transform the potential of somatic gene therapy, in terms of both its safety from creating unwanted mutations and its efficacy in delivering large amounts of DNA, which is founded on some pioneering work at Stanford in which she was also heavily involved.” says Aubrey de Grey.
https://www.undoing-aging.org/news/dr-ruby-yanru-chen-tsai-t…b5IQ0dQ64s
#undoingaging #sens #foreverhealthy
In a new study published in the journal Human Biology, archaeologists from the Tel Aviv University reveal the molecular similarities between Neanderthals and woolly mammoths by studying three case studies.
Scientists discover that two completely different species can evolve and develop the same genetic characteristics. In a landmark study, Neanderthals and woolly mammoths are found to be very similar to each other.
This article opened with some fearful figures about cancer and its effect on people worldwide. But there’s reason to hope.
While the total number of new cancer cases and deaths continues to increase, the rates of cancer diagnoses and deaths decline each year — as absolute figures don’t account for rises in life expectancy, population growth, or aging populations. We’ve made great strides in understanding the disease and its various genetic and environmental origins. And events like Breast Cancer Awareness Month continue to educate the populace about the preventative measures available to them.
Thanks to scientists like those at the University of Basel in Switzerland, we may have more reasons to be hopeful very soon.
