If we want to reach Mars, we may have to upgrade our DNA.
Category: genetics – Page 366
All children will be able to receive whole genome sequencing at birth, under ambitions laid out by the Health Secretary.
Matt Hancock said that in future, the tests would be routinely offered, alongside standard checks on newborns, in order to map out the risk of genetic diseases, and offer “predictive, personalised” care.
Ministers have already promised that such tests will be offered to all children diagnosed with cancer by the end of this year.
Scientists successfully extended the average lifespan of mice by breeding them using embryonic stem cells with extra-long telomeres. The findings are significant because the researchers managed to extend lifespan without genetic modification, and they also shed light on the aging process and techniques that might someday slow it.
The study — published October 17 in Nature Communications — focuses on telomeres, which are stretches of DNA found at the end of chromosomes.
Because telomeres protect the genetic material inside chromosomes, they’ve been likened to the plastic tips on the ends of shoelaces. But telomeres have also been compared to bomb fuses, or “molecular clocks,” because they become shorter each time a cell divides, eventually shrinking so much that the cell dies or stops dividing. This shortening of our telomeres is associated with aging, cancer, and death.
When the first smartphones arrived, few people understood how they would change our reality. Today, our internet-connected mobile device maps our travel, manages our finances, delivers our dinner, and connects us to every corner of human knowledge. In less than a generation, it has become almost an extension of our central nervous system — so indispensable that we can’t imagine leaving home without it to guide us.
We are about to embark on another journey even more important to every individual and to human society. We are entering the age of genomics, an amazing future that will dramatically improve the health outcomes of people across the planet. Soon, we won’t be able to imagine a time when we left home without knowledge of our genome to guide us.
But this future isn’t a generation away. As early as 2020, I believe we will be living in a world where software uses knowledge of our personal genome to guide us, like a health GPS, toward choices that are appropriate for us as individuals. From the foods we choose to eat to the medicines we take to prevent or cure disease, from helping us avoid exposure to environmental risks to eradicating thousands of genetic diseases, genomics will reveal such immense possibilities that it will feel as if we can see and hear for the first time.
Metabesity 2019: Epigenetic resetting of cellular age mediated by nuclear reprogramming – A new paradigm in overcoming aging and aging-associated diseases.
Featuring Vittorio Sebastiano, PhD, Assistant Professor of Stanford University; Co-Founder of Turn Biotechnologies, USA
For more information, see www.metabesity2019.com
Researchers at the University of Dundee have made a discovery they believe has the potential to put the brakes on the ‘runaway train’ that is Parkinson’s disease.
The team, based at the Medical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU) in the School of Life Sciences, have discovered a new enzyme that inhibits the LRRK2 pathway. Mutations of the LRRK2 gene are the most common cause of genetic Parkinson’s.
Enzymes are molecular machines that regulate the biological processes required to maintain healthy functioning life. They can also be targeted by drugs to increase or decrease the level of certain activity –in this instance the LRRK2 pathway.
Unlike chemotherapy or radiation, which attack cancer directly, CAR-T engineers patients’ immune cells so they can do it themselves. T-cells are removed from the blood and given new genes that produce receptors that let the T-cells recognize and bind to leukemia cells with a specific protein, CD19.
The genetically modified T-cells are then multiplied in the lab and infused back into the patient, where they ideally multiply even further and begin to target and kill cancer cells with CD19.
David Pearce — The Anatomy of Happiness
“While researching epilepsy, neuroscientist Itzhak Fried stumbled on a ‘mirth’ center in the brain — given this, what ought we be doing to combat extreme suffering and promote wellbeing?”
David Pearce — The Anatomy of Happiness… While researching epilepsy, neuroscientist Itzhak Fried stumbled on a ‘mirth’ center in the brain — given this, what ought we be doing to combat extreme suffering and promote wellbeing?
This is a clip from a conversation with Michio Kaku from Oct 2019. New full episodes once or twice a week and 1–2 new clips or a new non-podcast video on all other days. You can watch the full conversation here: https://www.youtube.com/watch?v=kD5yc1LQrpQ
(more links below)
Podcast full episodes playlist:
Podcasts clips playlist:
Podcast website:
A pair of new studies report “impressive” benefits from a drug therapy for cystic fibrosis, a deadly and devastating disease that affects tens of thousands of people worldwide, the director of the National Institutes of Health wrote in an editorial published in The New England Journal of Medicine on Thursday.
“These findings indicate that it may soon be possible to offer safe and effective molecularly targeted therapies to 90 percent of persons with cystic fibrosis,” wrote the director, Dr. Francis S. Collins, who led the team that in 1989 identified the gene that causes the genetic disease affecting the lungs and digestive system.
“This should be a cause for major celebration,” he wrote in the Thursday editorial.