Lifeboat Foundation

“I was wrong,” Church now admits.

A startup he cofounded, eGenesis, had made news for its ambitious plans to use CRISPR gene-editing technology to modify pigs so their organs could be safely transplanted into humans without being rejected. That could solve a critical shortage of human organs available for transplant.

But no human test has yet been carried out. Instead, the company is currently testing organs from its pigs in monkeys at Massachusetts General Hospital in Boston. The experiments are being led by the hospital’s chief of transplant surgery, James Markmann.

Arizona State University has been selected to participate in DARPA’s Epigenetic CHaracterization and Observation (ECHO) program. According to DARPA, the “ECHO program has two primary challenges: to identify and discriminate epigenetic signatures created by exposure to threat agents; and to create technology that performs highly specific forensic and diagnostic analyses to reveal the exact type and time of exposure.” (Epigenetic changes are chemical modifications that affect genes, altering their expression while leaving the genetic code intact. Epigenetic changes can occur as natural responses to the environment but can also signal exposure to toxic agents or disease pathogens.)

Epigenetics is coming into its own in the 21st century. DARPA describes the epigenome as “biology’s record keeper,” explaining that “though DNA does not change over a single lifetime, a person’s environment may leave marks on the DNA that modify how that individual’s genes are expressed. This is one way that people can adapt and survive in changing conditions, and the epigenome is the combination of all of these modifications. Though modifications can register within seconds to minutes, they imprint the epigenome for decades, leaving a time-stamped biography of an individual’s exposures that is difficult to deliberately alter.”

Sethuraman Panchanathan, ASU Knowledge Enterprise executive vice president and chief research and innovation officer, said the project fits with the university’s mission.

The gene-editing approach might prove more useful outside the clinic.

Recently, we had the opportunity to interview Professor George Church, a well-known geneticist and rejuvenation expert whom we have previously interviewed. Prof. Church’s company, Rejuvenate Bio, will be launching a clinical trial to test a rejuvenation therapy in dogs this fall.

In your recent paper on enabling large-scale genome editing, you talked about manipulating endogenous transposable elements with the help of dead Cas9 base editors. At Ending Age-Related Diseases, Andrei Gudkov spoke about the super mutagenic phenotype that arises from the expression of LINE1 reverse transcriptase. In this context, he mentioned the possibility of the retrobiome (as he referred to it) being the main driver of all types of cellular damage, which is consequently improperly addressed due to immunosenescence. Do you share his views on the contribution of LINEs and SINEs in aging? If not, why?

Yes. That is one of the reasons why we explored the tech for editing of repeats. We are now extending this to the germline engineering of repeats.

HELLO! https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025786/

With approximately 40 million adults across the United States experiencing anxiety each year, scientists and researchers have dedicated their careers to trying to better understand this condition. Despite this work, we are still somewhat unclear on what actually causes this condition to occur.

Continue reading “Panic Attacks and Anxiety Episodes Linked to Vitamin Deficiencies in Groundbreaking Study” »

Scientists from the University of Exeter believe it may be possible to avoid developing dementia, and there are 5 ways that can help to reduce the risk, findings were presented at the Alzheimer’s Association International Conference.

As published in the journal JAMA living a healthy lifestyle may help reduce the risk of dementia even if you have a genetic risk; risk of dementia in those with a higher genetic risk who followed a healthy lifestyle were found to be at 32% lower risk than those with an unhealthy lifestyle.

Data was studied from 196,383 adults of European ancestry who were 60+ years old; 1,769 cases of dementia were identified over an 8 years follow up period; those with high genetic risk and an unhealthy lifestyle were found to be almost 3 times more likely to develop dementia.

https://www.prweb.com/releases/regenerage_international_iime…449142.htm

You OWN your DNA data Let’s keep it that way.

EDNA Members monetize their genetic data by selling access to their data direct to researchers. With an average selling price of $350.00 and an average expectancy of up to 200 deals, this can translate to as much as $70,000.00 per person. Intended use and licensing of this data is controlled by smart contract and may include posted bonds provided by researchers to insure confidentiality and security of the data. Don’t give away this highly-valuable property. Claim it for yourself. Opt-In only when YOU decide. It’s your property and you should be in control.

Two important developers of the celebrated Crispr gene-editing technology said they will make it easier for researchers to license their intellectual property, a move aimed at hastening innovation in the burgeoning field.

MilliporeSigma, the life-sciences tools division of German pharmaceutical giant Merck KGaA, and the Broad Institute of MIT and Harvard said researchers will be able to get nonexclusive rights to patents held by both organizations for research purposes with a single license.

Companies will have to pay a licensing fee. Nonprofit and academic institutions will be permitted to license the patents for free, the organizations said in a news release on Thursday.