Menu

Blog

Archive for the ‘genetics’ category: Page 291

May 11, 2020

Stem cell treatment in the UAE sees ‘favorable’ outcomes for coronavirus patients

Posted by in categories: biotech/medical, genetics, health

Stem Cell Neurotherapy sends therapeutic messages, e.g., “your stem cells are transforming into new cells for the lungs, liver, and kidneys” to the DNA inside the nucleus of stem cells. Inside the nucleus, the DNA receives the message and transmits it to the RNA, which translates the message into genetic code.

The genes inside the stem cells transmit the coded message to the proteins, which are converted by the mitochondria into ATP, which provides the energy for the coded message to transform the stem cells into a new set of lung cells, as well as new cells for the kidneys and liver.

These new cells in the lungs, kidneys, and liver will replace the cells that were infected by the COVID-19 virus. This results in the elimination of the coughing, fever, headaches, diarrhea, and breathing problems.

Continue reading “Stem cell treatment in the UAE sees ‘favorable’ outcomes for coronavirus patients” »

May 11, 2020

Stem cell treatment for coronavirus symptoms being trialed in the UAE

Posted by in categories: biotech/medical, genetics, neuroscience

We repurposed some tools from the Stem Cell Therapy for Cancer/Brain Tumor. Those tools are T-Cells, B-Cells, and Natural Killer Cells. Instead of programming those cancer killing cells to attack cancer cells, we have programmed them to seek out, identify, attack, and destroy all the Coronavirus cells in the entire body.

Stem Cell Neurotherapy sends therapeutic messages, e.g., “your stem cells are transforming into new cells for the lungs, liver, and kidneys” to the DNA inside the nucleus of stem cells. Inside the nucleus, the DNA receives the message and transmits it to the RNA, which translates the message into genetic code.

The genes inside the stem cells transmit the coded message to the proteins, which are converted by the mitochondria into ATP, which provides the energy for the coded message to transform the stem cells into a new set of lung cells, as well as new cells for the kidneys and liver.

May 10, 2020

Reversing age: dual species measurement of epigenetic age with a single clock

Posted by in categories: biotech/medical, chemistry, finance, genetics, life extension, neuroscience

Young blood plasma is known to confer beneficial effects on various organs in mice. However, it was not known whether young plasma rejuvenates cells and tissues at the epigenetic level; whether it alters the epigenetic clock, which is a highly-accurate molecular biomarker of aging. To address this question, we developed and validated six different epigenetic clocks for rat tissues that are based on DNA methylation values derived from n=593 tissue samples. As indicated by their respective names, the rat pan-tissue clock can be applied to DNA methylation profiles from all rat tissues, while the rat brain-, liver-, and blood clocks apply to the corresponding tissue types. We also developed two epigenetic clocks that apply to both human and rat tissues by adding n=850 human tissue samples to the training data. We employed these six clocks to investigate the rejuvenation effects of a plasma fraction treatment in different rat tissues. The treatment more than halved the epigenetic ages of blood, heart, and liver tissue. A less pronounced, but statistically significant, rejuvenation effect could be observed in the hypothalamus. The treatment was accompanied by progressive improvement in the function of these organs as ascertained through numerous biochemical/physiological biomarkers and behavioral responses to assess cognitive functions. Cellular senescence, which is not associated with epigenetic aging, was also considerably reduced in vital organs. Overall, this study demonstrates that a plasma-derived treatment markedly reverses aging according to epigenetic clocks and benchmark biomarkers of aging.

Several authors are founders, owners, employees (Harold Katcher and Akshay Sanghavi) or consultants of Nugenics Research (Steve Horvath and Agnivesh Shrivastava) which plans to commercialize the “Elixir” treatment. Other authors (Kavita Singh, Shraddha Khairnar) received financial support from Nugenics Research. The other authors do not have conflict of interest.

May 8, 2020

FDA authorizes CRISPR-based test for COVID-19

Posted by in categories: biotech/medical, genetics

CRISPR technology can quickly find and lock onto genetic sequences, like the one in the coronavirus. The test from Sherlock Biosciences uses that system to identify the virus in a patient sample.

May 8, 2020

CRISPR Used Inside a Person’s Body for the First Time Ever

Posted by in categories: bioengineering, biotech/medical, genetics

Doctors at the Casey Eye Institute at Oregon Health & Science University in Portland have announced the first-ever use of the revolutionary gene editing tool, CRISPR, inside of a person’s body. The tool was used to modify the genes responsible for a particular form of inherited blindness, and those responsible for the pioneering effort say there is real potential here to not only restore the patient’s vision, but open up a new line of medicines specifically used to target and alter DNA.

In an Associated Press report, which comes via NBC, the companies that make the treatment used in the procedure, including Cambridge, Massachusetts-based Editas Medicine and Dublin-based Allergan, highlighted the possibilities moving forward if the trial proves to be successful. Charles Albright, chief scientific officer at Editas, said that “We literally have the potential to take people who are essentially blind and make them see.”

Continue reading “CRISPR Used Inside a Person’s Body for the First Time Ever” »

May 8, 2020

Scientists Buzzing Over Virgin Birth and Genetic Mystery That’s Been Solved

Posted by in categories: biological, genetics, sex

In a study published on May 7, 2020, in Current Biology, researchers from University of Sydney have identified the single gene that determines how Cape honey bees reproduce without ever having sex. One gene, GB45239 on chromosome 11, is responsible for virgin births.

“It is extremely exciting,” said Professor Benjamin Oldroyd in the School of Life and Environmental Sciences. “Scientists have been looking for this gene for the last 30 years. Now that we know it’s on chromosome 11, we have solved a mystery.”

Behavioral geneticist Professor Oldroyd said: “Sex is a weird way to reproduce and yet it is the most common form of reproduction for animals and plants on the planet. It’s a major biological mystery why there is so much sex going on and it doesn’t make evolutionary sense. Asexuality is a much more efficient way to reproduce, and every now and then we see a species revert to it.”

May 7, 2020

The Harvard Wyss Institute’s response to COVID-19: beating back the coronavirus

Posted by in categories: biotech/medical, genetics, health

Diagnosing COVID-19 more quickly, easily, and broadly

With COVID-19 rapidly spreading around the planet, the efficient detection of the CoV2 virus is pivotal to isolate infected individuals as early as possible, support them in whatever way possible, and thus prevent the further uncontrolled spread of the disease. Currently, the most-performed tests are detecting snippets of the virus’ genetic material, its RNA, by amplifying them with a technique known as “polymerase chain reaction” (PCR) from nasopharyngeal swabs taken from individuals’ noses and throats.

The tests, however, have severe limitations that stand in the way of effectively deciding whether people in the wider communities are infected or not. Although PCR-based tests can detect the virus’s RNA early on in the disease, test kits are only available for a fraction of people that need to be tested, and they require trained health care workers, specialized laboratory equipment, and significant time to be performed. In addition, health care workers that are carrying out testing are especially prone to being infected by CoV2. To shorten patient-specific and community-wide response times, Wyss Institute researchers are taking different parallel approaches:

May 6, 2020

14 mutations found in SARS-CoV-2: One strain may be more easily spread

Posted by in categories: biotech/medical, education, genetics

A team of researchers from Los Alamos National Laboratory, Sheffield Teaching Hospitals NHS and the Duke Human Vaccine Institute and Department of Surgery has found 14 mutations to the SARS-CoV-2 virus, one of which they suspect might be more easily spread. In the interest of speedy dissemination of findings, the group has uploaded their paper to the bioRxiv preprint server rather than waiting for peer review at another journal.

The work involved analyzing the genomes of the virus found in 6,000 infected people from around the globe. They focused most specifically on the virus genes that are responsible for producing the “spike protein,” which is the mechanism the virus uses to attach to human cells. In so doing, they found 14 mutations, but one they named D614G (also known as G614) stood out because it was found in almost all samples outside of China. It was also particularly notable because it appeared to replace a prior mutation called D614. They also noted that in the original outbreak in China, there were only D614 mutations. It was only after the virus began appearing in Europe that the G614 mutation emerged. They suggest that the fact that the G614 virus took over from the prior mutation could mean it is more easily spread.

May 5, 2020

Hidden Symmetry Discovered in Chemical Kinetic Equations – Significant for Drug Design, Genetics & More

Posted by in categories: biotech/medical, chemistry, genetics, information science

Rice University researchers have discovered a hidden symmetry in the chemical kinetic equations scientists have long used to model and study many of the chemical processes essential for life.

The find has implications for drug design, genetics and biomedical research and is described in a study published on April 21, 2020, in the Proceedings of the National Academy of Sciences. To illustrate the biological ramifications, study co-authors Oleg Igoshin, Anatoly Kolomeisky and Joel Mallory of Rice’s Center for Theoretical Biological Physics (CTBP) used three wide-ranging examples: protein folding, enzyme catalysis and motor protein efficiency.

Igoshin said the symmetry “wasn’t that hard to prove, but no one noticed it before.”

May 5, 2020

Mechanisms of viral mutation

Posted by in categories: biotech/medical, genetics, robotics/AI

Why hasn’t #MachineLearning conquered SARS-CoV-2 that causes COVID-19 (P.S., SARS-CoV-2 is the name of the #virus, while COVID-19 is the name of the disease)? One of the possible answers is that the virus “learns” faster than machines through “mutations”.

That causes us thinking: If mutation is such an efficient weapon (for virus), can we learn something from it and then apply our understanding to #DeepLearning to create “fast-mutating” #DeepLearning models capable of helping us to fight intractable crisis like a #pandemic?

https://bit.ly/3c9GE5s

Continue reading “Mechanisms of viral mutation” »