Some thoughts about the genetic code aliens would use in the 2nd part of the series: The Science of Aliens:
Alien life would likely have different biochemistry, which may change the way it reproduces.
Methuselah the tree was grown from a 2000-year-old seed found at Masada. Now more have been grown and genetic analysis finds a twist in the origin story of the ‘Judean date’.
Stress management.
Everyone faces stress occasionally, whether in school, at work, or during a global pandemic. However, some cannot cope as well as others. In a few cases, the cause is genetic. In humans, mutations in the OPHN1 gene cause a rare X-linked disease that includes poor stress tolerance. Cold Spring Harbor Laboratory (CSHL) Professor Linda Van Aelst seeks to understand factors that cause specific individuals to respond poorly to stress. She and her lab studied the mouse gene Ophn1, an analog of the human gene, which plays a critical role in developing brain cell connections, memories, and stress tolerance. When Ophn1 was removed in a specific part of the brain, mice expressed depression-like helpless behaviors. The researchers found three ways to reverse this effect.
To test for stress, the researchers put mice into a two-room cage with a door in between. Normal mice escape from the room that gives them a light shock on their feet. But animals lacking Ophn1 sit helplessly in that room without trying to leave. Van Aelst wanted to figure out why.
Continue reading “Reversing a Genetic Cause of Poor Stress Tolerance” »
The unprecedented study involves using the gene-editing technique CRISPR to edit a gene while it’s still inside a patient’s body. In exclusive interviews, NPR talks with two of the first participants.
Autistic people tend to switch between images more slowly than non-autistic people do, a previous study shows. And they spend more time seeing a combination of the two images.
Children with genetic conditions linked to autism perform atypically on a test of binocular rivalry, according to a new unpublished study.
Researchers presented the work virtually today at the 2021 International Society for Autism Research annual meetin g. (Links to abstracts may work only for registered conference attendees.)
Continue reading “Autism-related conditions linked to altered visual perception” »
7:01 they talk about Church’s comments of ending aging by 2030. Also this appears to be a part one.
In this video Professor Church talks about his theory of aging and touches on his ideas on the future of aging.
Continue reading “My Theory & The Future Of Aging | Prof George Church Interview Series Episode 1” »
I still don’t get how there seems to be No organized effort anywhere to achieve the ability to 3D print a perfect genetic match of all organs by 2025 — 2030. You would think some government somewhere would want to work round the clock on this.
NIBIB-funded engineers at the University of Buffalo have fine-tuned the use of stereolithography for 3D printing of organ models that contain live cells. The new technique is capable of printing the models 10–50 times faster than the industry standard-;in minutes instead of hours-; a major step in the quest to create 3D-printed replacement organs.
Conventional 3D printing involves the meticulous addition of material to the 3D model with a small needle that produces fine detail but is extremely slow —taking six or seven hours to print a model of a human part, such as a hand, for instance. The lengthy process causes cellular stress and injury inhibiting the ability to seed the tissues with live, functioning cells.
Continue reading “New technique can print life-like organ models in minutes” »
After doubling its sample size, the largest study of genetic data from autistic people has identified 255 genes associated with the condition, an increase of more than 40 genes since the researchers’ 2019 update; 71 of the genes rise above a stringent statistical bar the team had not previously used. The new analysis also adds data from people with developmental delay or schizophrenia and considers multiple types of mutations.
“It’s a really significant step forward in what we do,” said Kyle Satterstrom, a computational biologist in Mark Daly’s lab at the Broad Institute in Cambridge, Massachusetts. Satterstrom presented the findings virtually on Tuesday at the 2021 International Society for Autism Research annual meeting. (Links to abstracts may work only for registered conference attendees.)
The team’s previous analyses used data from the Autism Sequencing Consortium, which enrolls families through their doctors. The researchers mainly scoured the genetic data to find rare, non-inherited mutations linked to autism.
People who reach a very old age may have their genes to thank. Genetic variants that help to prevent DNA mutations and repair any that do occur have been found in supercentenarians and semi-supercentenarians – people who reach the ages of 110 and 105, respectively.
“DNA repair mechanisms are extremely efficient in these people,” says Claudio Franceschi at the University of Bologna in Italy. “It is one of the most important basic mechanisms for extending lifespan.”
The human cells grew inside all 132 of the embryos after just 24 hours. After ten days, 103 chimeric embryos remained. By day 19, however, only three chimeras were left alive – and they were then terminated.
“This knowledge will allow us to go back now and try to re-engineer these pathways that are successful for allowing appropriate development of human cells in these other animals,” Juan Carlos Izpisua Belmonte, genetics professor at the Salk Institute for Biological Sciences in La Jolla, California and co-author of the study, told NPR.
“We are very, very excited,” he added.
