Lifeboat Foundation

Dr Vittorio Sabastiano explains the possibilities on resetting the age of any cell type in the near future in this clip.

Dr. Vittorio Sebastiano is an Assistant Professor in the Department of Obstetrics and Gynecology at Stanford School of Medicine. His lab has established a new technology named ERA (Epigenetic Reprogramming of Aging), which repurposes the conceptual idea of reprogramming, with the goal to promote epigenetic rejuvenation of adult cells leaving their identity untouched. This new technology was patented and is being implemented by Turn Biotechnologies, of which Dr. Sebastiano is co-founder and Chair of the Scientific Advisory Board.

Continue reading “FOREVER YOUNG — The Peter Pan Case | Dr Vittorio Sabastiano Interview Clips” »

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Continue reading “Quantifying Biological Age: Blood Test #5 in 2022” »

Summary: A new study reveals a genetic link between Alzheimer’s disease and several gut-related disorders. Researchers report Alzheimer’s patients and those with intestinal disorders have specific genes in common. The findings add to the evidence the gut-brain axis may play a role in the development of neurodegenerative disorders.

Source: Edith Cowan University.

People with gut disorders may be at greater risk of developing Alzheimer’s Disease (AD).

Most common genetic causes of a rare condition called “uncombable hair syndrome” have been found.

Foresight Existential Hope Group.
Program & apply to join: https://foresight.org/existential-hope/

In the Existential Hope-podcast (https://www.existentialhope.com), we invite scientists to speak about long-termism. Each month, we drop a podcast episode where we interview a visionary scientist to discuss the science and technology that can accelerate humanity towards desirable outcomes.

Xhope Special with Foresight Fellow Morgan Levine.

Morgan Levine is a ladder-rank Assistant Professor in the Department of Pathology at the Yale School of Medicine and a member of both the Yale Combined Program in Computational Biology and Bioinformatics, and the Yale Center for Research on Aging. Her work relies on an interdisciplinary approach, integrating theories and methods from statistical genetics, computational biology, and mathematical demography to develop biomarkers of aging for humans and animal models using high-dimensional omics data. As PI or co-Investigator on multiple NIH-, Foundation-, and University-funded projects, she has extensive experience using systems-level and machine learning approaches to track epigenetic, transcriptomic, and proteomic changes with aging and incorporate.
this information to develop measures of risk stratification for major chronic diseases, such as cancer and Alzheimer’s disease. Her work also involves development of systems-level outcome measures of aging, aimed at facilitating evaluation for geroprotective interventions.

Continue reading “Existential Hope Special with Morgan Levine” »

Immortality exists – but to get it, you need to be a jellyfish, not a god or a vampire. Moreover, only one species of cnidarian, Turritopsis dohrnii, is known to have found the secret of eternal life. Geneticists hope comparing T. dornii’s DNA with its close relative, T. rubra, will help us understand the aging process and how to evade it.

Turritopsis are warm water jellyfish half a centimeter (0.2 inches) long. At least three species of hydra have the capacity to age backwards like Benjamin Button, going from adult to juvenile stage, before eventually growing up again. However, two of these can only go from the hydra equivalent of adolescent to child; like the victim in some uncensored fairytale, sexual reproduction locks them into adulthood. T. dohrnii, on the other hand, appears able to go from its free-floating adult stage to bottom-living polyp, known as life cycle reversal (LCR), as many times as it wants.

A paper in the journal Proceedings of the National Academy of Sciences provides a comparison of T. dorhnii and T. rubra in the hope the differences will prove enlightening, throwing in a few more distantly related types of cnidarians as well.

Managing Complex Transplant (and Xenotransplant) Cases Globally — Dr Robert A Montgomery, MD, DPhil, FACS, Director, NYU Langone Health

Dr. Robert A. Montgomery, MD, DPhil, FACS, (https://nyulangone.org/doctors/1467404137/robert-montgomery) is the Director of the NYU Langone Transplant Institute, and Chair and a Professor in their Department of Surgery, where he oversees a diverse team of medical and surgical specialists who provide a wide variety of surgery and transplantation services including bone marrow, heart, kidney, liver, lung, and facial transplantation.

Continue reading “Dr Robert A. Montgomery, MD, DPhil, FACS — NYU Langone — Managing Complex Transplant Cases Globally” »

Circa 2020 The axolotl’s ability to regenerate limbs has now be localized by researchers. This can lead to an end of illness and aging aswell.

A novel CRISPR-based genetic screen of candidate regeneration genes in haploid axolotl limbs reveals two genes required for proper regeneration.