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Researchers at the University at Albany’s RNA Institute have demonstrated a new approach to DNA nanostructure assembly that does not require magnesium. The method improves the biostability of the structures, making them more useful and reliable in a range of applications. The work appears in the journal Small this month.

When we think of DNA, the first association that comes to mind is likely genetics—the double helix structure within cells that houses an organism’s blueprint for growth and reproduction. A rapidly evolving area of DNA research is that of DNA nanostructures—synthetic molecules made up of the same building blocks as the DNA found in living cells, which are being engineered to solve critical challenges in applications ranging from medical diagnostics and drug delivery to materials science and data storage.

“In this work, we assembled DNA nanostructures without using magnesium, which is typically used in this process but comes with challenges that ultimately reduce the utility of the nanostructures that are produced,” said Arun Richard Chandrasekaran, corresponding author of the study and senior research scientist at the RNA Institute.

Summary: Researchers discovered sequence variants in the gene ABCC9 that influence voice pitch.

Utilizing speech recordings from nearly 13,000 Icelanders and corresponding genomic data, the scientists identified common ABCC9 variants associated with higher voice pitch in both men and women. Additionally, these variants were linked to higher pulse pressure, revealing intriguing connections between voice pitch and health.

The study also uncovered a heritable component in vowel acoustics, enhancing our understanding of the human vocal system.

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We often discuss cybernetic, genetic engineering, artificial intelligence, and hybrids of them, but what truly is synthetic life? And what is it like?

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In a paper published in Science Advances, an international team led by deCODE genetics, a subsidiary of Amgen, reveals the discovery of sequence variants in the gene ABCC9 that influence the pitch of voices.

Speaking is one of the most characteristic human behaviors, and yet the genetic underpinnings of voice and speech are largely unknown. In the first study of its kind, the scientists combined speech recordings from almost 13,000 Icelanders with data, in the sequence of the genome, to search for common variants in ABCC9 that are associated with a higher-pitched voice.

Continue reading “Study reveals first genetic locus for voice pitch” »

The Human Genome Project (HGP), the world’s largest collaborative biological project, was a 13-year effort led by the U.S. government with the goal of generating the first full sequence of the human genome. In 2003, HGP produced a genome sequence that accounted for more than 90% of the human genome and was considered as close to complete as was possible with the technologies of the time. HGP unlocked the door to a vast but unannotated collection of genes.

In the following decades, via experimental studies, researchers painstakingly curated reannotations in the form of biochemical reaction graphs. Though gene set enrichment analysis considers groups within these annotation graphs, it disregards group dependencies.

Researchers from the University of Hawaii at Mānoa John A. Burns School of Medicine (JABSOM) are utilizing data from HGP and making advancements in biochemical reaction network analysis. Their work, published in the May 22, 2023 issue of Patterns, demonstrates their approach and may help predict the effects of rare or indistinct genetic variations and guide precision medicine (treatment that can use a patient’s own genes to help fight disease or guide specific therapy).

Former Google engineer and esteemed futurist Ray Kurzweil has made another bold prediction: Immortality is within reach for humans by 2030, thanks to the help of nanorobots. You read that right — humans could potentially live forever, according to Kurzweil.

Don’t Miss: Why Jason Calacanis and Other Silicon Valley Elites Are Betting On This Startups Vision For Re-Uniting American Families

Kurzweil, who has a track record of accurate predictions such as foreseeing a computer beating humans in chess by 2000, shared his prediction in a recent YouTube series by tech vlogger Adagio. The 75-year-old computer scientist believes that advancements in genetics, robotics and nanotechnology will allow tiny robots to run through veins, repairing any damage and keeping people alive indefinitely.

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