A U.K. teen with an aggressive form of leukemia is now cancer-free, thanks to a new gene-editing therapy.
The particular therapy used on the patient was only invented six years ago, and it’s now making doctors rethink the way doctors approach the disease.
Continue reading “Revolutionary gene-editing therapy treats girl’s ‘incurable’ cancer” »
Sucralose, a widely used artificial sweetener, produces a DNA
DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).
Schooling, socioeconomic status (SES), and genetics all impact intelligence. However, it is unclear to what extent their contributions are unique and if they interact. Here we used a multi-trait polygenic score for cognition (cogPGS) with a quasi-experimental regression discontinuity design to isolate how months of schooling relate to intelligence in 6,567 children (aged 9–11). We found large, independent effects of schooling (β ~ 0.15), cogPGS (β ~ 0.10), and SES (β ~ 0.20) on working memory, crystallized (cIQ), and fluid intelligence (fIQ). Notably, two years of schooling had a larger effect on intelligence than the lifetime consequences, since birth, of SES or cogPGS-based inequalities. However, schooling showed no interaction with cogPGS or SES for the three intelligence domains tested.
In a recent study published in Nature Medicine, researchers conducted a genome-wide analysis of prostate-specific antigen (PSA) levels of men without prostate cancer to understand the non-cancer-related variation in PSA levels to improve decision-making during the diagnosis of prostate cancer.
Study: Genetically adjusted PSA levels for prostate cancer screening. Image Credit: luchschenF/Shutterstock.com.
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Continue reading “Resveratrol Extends Lifespan, But Only Under Two Experimental Conditions” »
A team of medical scientists at The Catholic University of America, in Washington, D.C., working with a colleague from Purdue University, has developed a way to engineer the bacteriophage T4 to serve as a vector for molecular repair. The study is reported in the journal Nature Communications.
Prior research has shown that many human ailments arise due to genetic mutations: cystic fibrosis, Down syndrome, sickle cell disease and hemophilia are just a few. Logic suggests that correcting such genetic mutations could cure these diseases. So researchers have been working toward developing gene editing tools that will allow for safe editing of genes.
One of the most promising is the CRISPR gene editing system. In this new effort, the research team took a more general approach to solving the problem by working to develop a vector that could be used to carry different kinds of tools to targeted cells and then enter them to allow for healing work to commence.
Contemporary DNA
DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).
Crispre cas 9.
A major issue in neuroscience is the poor translatability of research results from preclinical studies in animals to clinical outcomes. Comparative neuroscience can overcome this barrier by studying multiple species to differentiate between species-specific and general mechanisms of neural circuit functioning. Targeted manipulation of neural circuits often depends on genetic dissection, and use of this technique has been restricted to only a few model species, limiting its application in comparative research. However, ongoing advances in genomics make genetic dissection attainable in a growing number of species. To demonstrate the potential of comparative gene editing approaches, we developed a viral-mediated CRISPR/Cas9 strategy that is predicted to target the oxytocin receptor (Oxtr) gene in 80 rodent species. This strategy specifically reduced OXTR levels in all evaluated species (n = 6) without causing gross neuronal toxicity. Thus, we show that CRISPR/Cas9-based tools can function in multiple species simultaneously. Thereby, we hope to encourage comparative gene editing and improve the translatability of neuroscientific research.
The development of comparative gene editing strategies improves the translatability of animal research.
Year 2014 face_with_colon_three
For the first time, researchers create a new organism based on E. coli that passes along artificially engineered DNA.
Year 2020 o.o!!!
The primary difficulty of interstellar communication is finding common ground between ourselves and other intelligent entities about which we can know nothing with absolute certainty. This common ground would be the basis for a universal language that could be understood by any intelligence, whether in the Milky Way, Andromeda, or beyond the cosmic horizon. To the best of our knowledge, the laws of physics are the same throughout the universe, which suggests that the facts of science may serve as a basis for mutual understanding between humans and an extraterrestrial intelligence.
One key set of scientific facts presents an intriguing question. If aliens were to visit Earth and learn about its inhabitants, would they be surprised that such a wide variety of species all share a common genetic code? Or would this be all too familiar? There is probable cause to assume that the structure of genetic material is the same throughout the universe and that, while this is liable to give rise to life forms not found on Earth, the variety of species is fundamentally limited by the constraints built into the genetic mechanism.
