Loss of lipin1 disrupts heart muscle membrane integrity, driving inflammation, fibrosis, and contributing to heart failure.

BackgroundLipin1 has dual functions acting as phosphatidic acid phosphatase required for lipid synthesis and as a transcriptional coactivator. Our previous research demonstrated that lipin1 is critical for maintaining sarcolemmal integrity in skeletal muscle. Given the importance of sarcolemmal stability for cardiac muscle viability and function, we investigated the role of lipin1 in the heart using a novel cardiac‐specific lipin1 deficient (Myh6‐lipin 1^−/−) mouse model.

Scientists discover unique 20 km long rock structure beneath Bermuda, explaining the uplift of the ocean floor without active volcanism.

🦄❤️🦄❤️🦄❤️

Join the discussion on this paper page.

Liquids and solutions may look simple, but on the molecular scale they are constantly shifting and reorganizing. When sugar dissolves in water, each sugar molecule quickly becomes surrounded by fast moving water molecules. Inside living cells, the situation is even more intricate. Tiny liquid drople

One of nature’s most familiar forces might be doing something far stranger than we ever imagined.

The relationship between age and recovery after spinal cord injury: a longitudinal cohort study.

A high-sensitivity measurement reveals the asymmetric shifts of electrons along atomic bonds.

The jsPDF library for generating PDF documents in JavaScript applications is vulnerable to a critical vulnerability that allows an attacker to steal sensitive data from the local filesystem by including it in generated files.

The flaw is a local file inclusion and path traversal that allows passing unsanitized paths to the file loading mechanism (loadFile) in jsPDF versions before 4.0. It is tracked as CVE-2025–68428 and received a severity score of 9.2.

The jsPDF library is a widely adopted package with more than 3.5 million weekly downloads in the npm registry.

Letters to the Editor.

The Letters section represents an opportunity for ongoing author debate and post-publication peer review. View our submission guidelines for Letters to the Editor before submitting your comment.

View the Letters for this article.

The jawbones and vertebrae of a hominin that lived 773,000 years ago have been found in North Africa and could represent a common ancestor of Homo sapiens, Neanderthals and Denisovans.

By James Woodford