Researchers turn to synchrotron imaging of historical and homemade prints to explore possible connections between early printing methods in Korea and Europe.

Observations of air-bubble mergers in water explain why dissolved salt slows this process and leads to foam.

Air bubbles churned up in pure water can easily merge. But bubbles merge far more slowly in seawater or in other liquids containing dissolved impurities, which is why such liquids often generate enduring foams. Now a team of engineers believes that it has identified the fundamental cause of the difference—subtle forces set up by electrolytes, mobile ions created when substances dissolve in liquids [1]. In a collision between two bubbles, these forces greatly reduce the rate at which the liquid separating the bubbles can flow away. This understanding, the researchers say, explains why foams arise so easily in salty seawater and could be useful in many industrial applications.

Solutions with high electrolyte concentrations often produce persisting foams, so researchers have suspected for decades that dissolved electrolytes somehow slow bubble mergers. The effect has remained mysterious, however, and many theories even suggest that electrolytes should speed up bubble mergers, says mechanical engineer Bo Liu of the University of Alberta in Canada.

An area known as Thacker Pass on the Nevada-Oregon border is home to clay that contain tens of millions of tons of lithium.

Alarmed by something popping up on your body that’s clearly not supposed to be there? These pictures from WebMD show you a few strange-bu t-true ailments that are scary looking but — for the most part — nothing to worry about.

The pain is invisible, but it’s there. Here are the stories of what it’s like to live with trigeminal neuralgia.

Newton thought that gravitation would happen instantly, propagating at infinite speeds. Einstein showed otherwise; gravity isn’t instant.

Background: T cells equipped with chimeric antigen receptors (CAR) have shown remarkable efficacy in targeting B lineage malignancies. Improvement of the CAR structure is needed, however, with a view to developing flexibly modifiable spacers that are inert in interactions with unwanted cells. Specifically, binding to cells carrying receptors for IgG’s crystallizable fragment (FcR), that recognize IgG-derived domains in CARs is to be avoided.

Methods: Two novel CARs targeting the CD19 antigen where the IgG1-CH2 and-CH3 domains were replaced with Ig-like domains from signal-regulatory protein α (SIRPα) were designed in silico. An IgG1-based CAR and a CAR lacking both SIRPα and IgG1 domains were used as comparators. The phenotype and memory phenotype of the expanded cells were analyzed by flow cytometry, and CAR T cell activation and cytotoxic efficacy were assessed in co-culture experiments in response to CD19⁺ target cells. Unwanted interactions with FcR-expressing myeloid cells were interrogated in co-culture assays with THP-1 monocytic cells.

Results: T cells carrying the novel SIRPα-based CARs enacted potent in vitro cytotoxicity against CD19 positive B-lineage leukemia cells, comparable to traditional IgG1-based CAR T cells. Co-culture of IgG1-based CAR T cells with FcR-expressing THP-1 monocytic cells led to prominent cell surface expression of CD69 on T cells together with production of Interleukin (IL)-2 and Interferon-γ, and production of IL-1β, indicating activation of the T cells and monocytes, respectively. Longer co-culture led to killing of the monocytes. No signs of T cell nor monocyte activation were detected in co-cultures of SIRPα-based CAR T cells with THP-1 cells. Arming T cells with the SIRPα-based CARs favored differentiation towards CD4⁺ phenotype during expansion, while the effects on memory phenotype of the T cells were equivalent between the SIRPα- and IgG1-based CARs. In a pilot experiment, T cells modified with one of the SIRPα-based CARs showed dose dependent leukemia cell control.