Migraines are characterized by moderate to severe headache attacks and are commonly considered polygenic disorders. Typically, migraines are treated with triptans like serotonin receptor agonists; however, the mechanisms of triptans are debated upon, with these agents only effective in only about 60% of the population.
A new Scientific Reports study discusses the mechanisms of triptans for the treatment of spontaneous migraine attacks by using transcriptomics and metabolomics.
In 2021, retired actor Bruce Willis gave video production firm DeepCake permission to use deepfake tech to insert his likeness into a series of advertisements — and the AI they trained for the project could allow him to keep entertaining fans well into the future.
Authorized deepfake: In March 2022, Willis’ family announced that he would be stepping away from acting due to a recent diagnosis of aphasia, a language disorder that was impairing his cognitive abilities.
One of the action star’s last projects was a series of ads for Russian telecom company MegaFon, but it turned out he didn’t really act in the commercials — the ads were deepfakes that used AI to insert Willis digitally into the videos.
Calculations inscribed on a clay tablet helped ancient people document property boundaries, new research suggests.
At the University of Oxford, scientists have developed a nanopore technology that can identify three different post-translational modifications (PTMs) in individual proteins, even deep within long protein chains. The scientists asserted that their technology “[lays] the groundwork for compiling inventories of the proteoforms in cells and tissues.”
The technology was introduced in Nature Nanotechnology, in a paper titled, “Enzyme-less nanopore detection of post-translational modifications within long polypeptides.” The paper noted that single-molecule proteoform identification requires knowledge of the architecture of long polypeptide chains, knowledge that has proven elusive. Although there are methods for translocating folded proteins through solid-state nanopores or protein nanopores of large sizes, these methods have yet to locate PTMs within a polypeptide sequence. The methods that have detected PTMs have been able to do so only within short peptides.
In their paper, the Oxford scientists described their approach: We use electro-osmosis in an engineered charge-selective nanopore for the non-enzymatic capture, unfolding, and translocation of individual polypeptides of more than 1,200 residues. Unlabeled thioredoxin polyproteins undergo transport through the nanopore, with directional co-translocational unfolding occurring unit by unit from either the C or N terminus. Chaotropic reagents at non-denaturing concentrations accelerate the analysis.
Matthias G. Fischer et al., 2023/bioRxiv.
A report suggests that our planet is home to 1031 viruses, and they are probably the most powerful beings in terms of population. They come in all kinds of shapes and forms, however, some are more bizarre than others.
The animals were thought to have gone extinct before the dinosaurs arrived on the scene.
Brian Kennedy, one of the lead scientists of NOAA’s deep sea expedition, said the stalked crinoid “are these big beautiful flower looking animals, but they grow on this long stalk. They’re called sea lilies, and that’s really what they look like a lot of times.”
“These were thought extinct, we thought they were a relic of pre-dinosaur times, and now we find they are one of the most common organisms in the deep sea.”
After the tragic implosion of the Titan submersible. OceanGate’s co-founder is all prepped up for another venture. The co-founder of OceanGate, Guillermo Söhnlein has grand aspirations for future. By 2050, he would like to see 1,000 humans living in the clouds of Venus.
Apple CEO Tim Cook says he isn’t afraid of criticism. Here’s how he’s learned to handle negative feedback.
