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Scap stabilizes PKM2 to promote glycolysis and enhance anti-fungal immunity in macrophages

Huang et al. identify Scap as a key regulator of macrophage anti-fungal immunity that stabilizes PKM2 and sustains glycolysis independently of SREBP-mediated lipid synthesis, thereby establishing a Scap-PKM2 axis essential for cytokine production, phagocytosis, and fungal control.

P53: from understanding its structure to advances in therapeutic targeting — Signal Transduction and Targeted Therapy

Wang, W., Liu, X., Liu, H. et al. p53: from understanding its structure to advances in therapeutic targeting. Sig Transduct Target Ther 11, 121 (2026). https://doi.org/10.1038/s41392-025-02549-5

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