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An inducible multiciliated cell line resolves proteome dynamics and identifies CDK7 as a conserved regulator

Camille Boutin, Laurent Kodjabachian et al. describe an inducible multiciliated cell line well suited for advanced microscopy and proteomic approaches. The study provides a detailed proteomic profiling of MCC during their differentiation.


Boutin et al., describe an inducible multiciliated cell line well suited for advanced microscopy and proteomic approaches. The study provides a detailed pr.

Immunotherapy plus chemotherapy before surgery shows promise for pancreatic cancer

A new UCLA investigator-initiated study has found that adding immunotherapy to standard chemotherapy before surgery is safe and shows promise for some patients with borderline-resectable pancreatic cancer, a disease that has historically been difficult to treat.

The findings, published in Nature Communications, show that while the combination did not produce a clear survival advantage for most patients, a notable subset experienced unusually deep and durable responses. It also helped some patients live long enough to reach surgery, shrank tumors and produced encouraging survival outcomes.

The study also revealed immune changes that may limit how well immunotherapy works in pancreatic cancer, offering important clues for how future treatment strategies could be refined to further improve patient outcomes.

Potential for microbial methanethiol-dependent dimethylsulfide production in different marine sediments

Guo et al. demonstrate that H2S/MeSH-dependent DMS production through the Mdd pathway is prevalent in different types of marine sediments, including pelagic deep-sea sediments, and may substantially contribute to oceanic DMS production.

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