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Researchers from the Sapienza University of Rome found that caffeine has a positive effect on endothelial cells, a group of cells responsible for vascular regeneration.

We studied the role of caffeine intake on endothelial function in SLE by assessing its effect on circulating endothelial progenitor cells (EPCs) both ex vivo in SLE patients and in vitro in healthy donors (HD) treated with SLE sera.

Methods.

Continue reading “Caffeine improves systemic lupus erythematosus endothelial dysfunction by promoting endothelial progenitor cells survival” »

New research from North Carolina State University shows that unique materials with distinct properties akin to those of gecko feet – the ability to stick to just about any surface – can be created by harnessing liquid-driven chaos to produce soft polymer microparticles with hierarchical branching on the micro-and nanoscale.

The findings, published today (October 14, 2019) in the journal Nature Materials, hold the potential for advances in gels, pastes, foods, nonwovens, and coatings, among other formulations.

The soft dendritic particle materials with unique adhesive and structure-building properties can be created from a variety of polymers precipitated from solutions under special conditions, says Orlin Velev, S. Frank and Doris Culberson Distinguished Professor of Chemical and Biomolecular Engineering at NC State and corresponding author of the paper.

Genetic analysis of cavity crud from two famed man-eating lions suggests the method could re-create diets of predators that lived thousands of years ago.

The new Guinness World Record holder’s logo is nearly invisible to the naked eye.

The edible transistor is based on an existing transistor architecture, utilizing CuPc as the active material. The key component, the electrolyte-gated OFET (EGOFET), operates at low voltages (1 V) and can function stably for more than a year. The transistor showed good reproducibility, with performance characteristics that pave the way for integrating these devices into more complex edible circuits.

The circuits are constructed on a derivative of cellulose with electrical contacts being printed using inkjet technology and a solution of gold particles (which are also commonly used in the food industry for decoration). The transistor “gate” is also food-grade. This component controls the flow of electrical current between the source and drain terminals, effectively acting as a switch or amplifier. This gate is made from a gel based on chitosan another food-grade ingredient used as a gelling agent.

The research team also explored the optical and morphological properties of CuPc thin films. They found that the thickness of the CuPc layer played a crucial role in the transistor’s performance. Thinner films displayed better charge transport properties, which are essential for creating high-performing, low-voltage devices. This detailed understanding of the material’s properties allowed the team to optimize the transistor’s design for use in real-world applications.

Mamma bears press pause on their early pregnancies, so that their cubs are born closer to a food filled spring. Researchers led by a team in Germany have now found this same pregnancy pause button exists in human cells too.

“Although we have lost the ability to naturally enter dormancy, these experiments suggest that we have nevertheless retained this inner ability and could eventually unleash it,” says molecular geneticist Nicolas Rivron from the Austrian Academy of Sciences (IMBA).

“Triggering a dormant state during an IVF procedure could provide a larger time window to assess embryo health and to synchronize it with the mother for better implantation inside the uterus.”

Summary: Researchers have developed an AI-powered “electronic tongue” capable of distinguishing subtle differences in liquids, such as milk freshness, soda types, and coffee blends. By analyzing sensor data through a neural network, the device achieved over 95% accuracy in identifying liquid quality, authenticity, and potential safety issues. Interestingly, when the AI was allowed to select its own analysis parameters, it outperformed human-defined settings, showing how it holistically assessed subtle data.

This technology, which uses graphene-based sensors, could revolutionize food safety assessments and potentially extend to medical diagnostics. The device’s AI insights also provide a unique view into the neural network’s decision-making process. This innovation promises practical applications across industries where quality and safety are paramount.

Billionaires are backing top scientists racing to develop tech that could reverse aging. Cellular reprogramming promises to rejuvenate the body… but how does it work, and is it safe?

00:00 – Introduction.
00:55 – The Role Of Stem Cells.
02:33 – What Is Aging?
03:24 – What Is Cellular Reprogramming?
03:56 – How The Yamanaka Factors Can Rejuvenate Cells.
05:35 – Why Scientists Want To Partially Reprogram Cells.
06:28 – How Humans Could Become More Resilient To Age-Related Diseases.
07:00 – How Johnny Huard Uses Cellular Reprogramming.
08:10 – How Cellular Reprogramming Could Shape The Future.
08:38 – Amazon’s Jeff Bezos Is Investing Billions With Altos Labs.
09:02 – How Harvard Professor David Sinclair Used Cellular Reprogramming on Mice.
10:07 – ChatGPT’s Sam Altman Launched Retro. Biosciences.
10:57 – The Risks of Cellular Reprogramming, Including Cancer.
12:56 – How the Tech World Is Investing In Biotech.
13:50 – Credits.

Continue reading “Scientists Are Closer Than Ever To Reverse Aging. How Does It Work? | Life Extended” »

Researchers at Duke-NUS Medical School have identified interleukin-11 (IL11) as a key factor in the ageing process. Elevated IL11 levels lead to fat accumulation and muscle loss—two major indicators of ageing. Inhibiting IL11 could enhance healthy lifespans.

Ageing populations pose significant health and economic challenges globally. Even a one-year increase in life expectancy could be valued at $38 trillion.

In a study published in Nature, the team demonstrated that anti-IL11 therapy not only counters the harmful effects of ageing but also increases lifespan by up to 25% in preclinical models. The therapy shifts metabolism from generating harmful white fat to beneficial brown fat, which helps burn calories and maintain body temperature.