Lifeboat Foundation

Transhumanists are redefining what it means to be human. This talk takes a deeper look at the movement and its implications for the future.
About this event.

From bionic eyes to designing new senses and extending life expectancy, transhumanists are redefining what it means to be human. This talk takes a deeper look at the movement and its implications for the future of humanity.

Continue reading “Transhumanism & The Future of Humanity” »

As part of its ongoing work to track variants, WHO’s Technical Advisory Group on SARS-CoV-2 Virus Evolution (TAG-VE) met on the 24 October 2022 to discuss the latest evidence on the Omicron variant of concern, and how its evolution is currently unfolding, in light of high levels of population immunity in many settings and country differences in the immune landscape. In particular, the public health implications of the rise of some Omicron variants, specifically XBB and its sublineages (indicated as XBB•, as well as BQ.1 and its sublineages (indicated as BQ.1•, were discussed. Based on currently available evidence, the TAG-VE does not feel that the overall phenotype of XBB* and BQ.1* diverge sufficiently from each other, or from other Omicron lineages with additional immune escape mutations, in terms of the necessary public health response, to warrant the designation of new variants of concern and assignment of a new label. The two sublineages remain part of Omicron, which continues to be a variant of concern. This decision will be reassessed regularly. If there is any significant development that warrant a change in public health strategy, WHO will promptly alert Member States and the public. XBB*XBB* is a recombinant of BA.2.10.1 and BA.2.75 sublineages. As of epidemiological week 40 (3 to 9 October), from the sequences submitted to GISAID, XBB* has a global prevalence of 1.3% and it has been detected in 35 countries. The TAG-VE discussed the available data on the growth advantage of this sublineage, and some early evidence on clinical severity and reinfection risk from Singapore and India, as well as inputs from other countries. There has been a broad increase in prevalence of XBB* in regional genomic surveillance, but it has not yet been consistently associated with an increase in new infections. While further studies are needed, the current data do not suggest there are substantial differences in disease severity for XBB* infections. There is, however, early evidence pointing at a higher reinfection risk, as compared to other circulating Omicron sublineages. Cases of reinfection were primarily limited to those with initial infection in the pre-Omicron period. As of now, there are no data to support escape from recent immune responses induced by other Omicron lineages. Whether the increased immune escape of XBB* is sufficient to drive new infection waves appears to depend on the regional immune landscape as affected by the size and timing of previous Omicron waves, as well as the COVID-19 vaccination coverage. BQ.1*BQ.1* is a sublineage of BA.5, which carries spike mutations in some key antigenic sites, including K444T and N460K. In addition to these mutations, the sublineage BQ.1.1 carries an additional spike mutation in a key antigenic site (i.e. R346T). As of epidemiological week 40 (3 to 9 October), from the sequences submitted to GISAID, BQ.1* has a prevalence of 6% and it has been detected in 65 countries. While there are no data on severity or immune escape from studies in humans, BQ.1* is showing a significant growth advantage over other circulating Omicron sublineages in many settings, including Europe and the US, and therefore warrants close monitoring. It is likely that these additional mutations have conferred an immune escape advantage over other circulating Omicron sublineages, and therefore a higher reinfection risk is a possibility that needs further investigation. At this time there is no epidemiologic data to suggest an increase in disease severity. The impact of the observed immunological changes on vaccine escape remains to be established. Based on currently available knowledge, protection by vaccines (both the index and the recently introduced bivalent vaccines) against infection may be reduced but no major impact on protection against severe disease is foreseen. Overall summaryThe Omicron variant of concern remains the dominant variant circulating globally, accounting for nearly all sequences reported to GISAID[1]. While we are looking at a vast genetic diversity of Omicron sublineages, they currently display similar clinical outcomes, but with differences in immune escape potential. The potential impact of these variants is strongly influenced by the regional immune landscape. While reinfections have become an increasingly higher proportion of all infections, this is primarily seen in the background of non-Omicron primary infections. With waning immune response from initial waves of Omicron infection, and further evolution of Omicron variants, it is likely that reinfections may rise further. The role of the TAG-VE is to alert WHO if a variant with a substantially different phenotype (e.g. a variant that can cause a more severe disease or lead to large epidemic waves causing increased burden to the healthcare system) is emerging and likely to pose a significant threat. Based on currently available evidence, the TAG-VE does not feel that the overall phenotype of XBB* and BQ.1* diverge sufficiently from each other, or from other Omicron sublineages with additional immune escape mutations, in terms of the necessary public health response, to warrant the designation of a new variant of concern and assignment of a new label, but the situation will be reassessed regularly. We note these two sublineages remain part of Omicron, which is a variant of concern with very high reinfection and vaccination breakthrough potential, and surges in new infections should be handled accordingly. While so far there is no epidemiological evidence that these sublineages will be of substantially greater risk compared to other Omicron sublineages, we note that this assessment is based on data from sentinel nations and may not be fully generalizable to other settings. Wide-ranging, systematic laboratory-based efforts are urgently needed to make such determinations rapidly and with global interpretability. WHO will continue to closely monitor the XBB* and BQ.1* lineages as part of Omicron and requests countries to continue to be vigilant, to monitor and report sequences, as well as to conduct independent and comparative analyses of the different Omicron sublineages. The TAG-VE meets regularly and continues to assess the available data on the transmissibility, clinical severity, and immune escape potential of variants, including the potential impact on diagnostics, therapeutics, and the effectiveness of vaccines in preventing infection and/or severe disease. [1] Weekly epidemiological update on COVID-19 — 26 October 2022 (who.int)

The cosmic explosion happened 11.5 billion years ago, when the universe was fairly young, and could shed light on the evolution of stars and galaxies.

Microbial life may have resided within the first four kilometers of Mars’s porous crust.

Four billion years ago, the solar system was still young. Almost fully formed, its planets were starting to experience asteroid strikes a little less frequently. Our own planet could have become habitable as long as 3.9 billion years ago, but its primitive biosphere was much different than it is today. Life had not yet invented photosynthesis, which some 500 million years later would become its main source of energy. The primordial microbes — the common ancestors to all current life forms on Earth — in our planet’s oceans, therefore, had to survive on another source of energy.

Some of the oldest life forms in our biosphere were microorganisms known as “hydrogenotrophic methanogens” that particularly benefited from the atmospheric composition of the time. Feeding on the CO₂ (carbon dioxide) and H2 (dihydrogen) that abounded in the atmosphere (with H2 representing between 0.01 and 0.1% of the atmospheric composition, compared to the current approximate of 0.00005%), they harnessed enough energy to colonize the surface of our planet’s oceans.

Continue reading “Mars shows how even the simplest life forms can destroy their own planet” »

The scientists said their spacetime simulation “agrees very well with theory.”

A team of physicists used a “quantum field simulator” to simulate a tiny expanding universe made out of ultracold atoms, a report from VICE

Simulating spacetime.

Continue reading “Scientists use a quantum state of matter to simulate the early universe’s expansion” »

The observation of the onset of turbulence in a gas of bosons allows researchers to explore how turbulence comes to life.

Despite over a century of trying, physicists have yet to develop a complete theory of turbulence—the complex, chaotic motion of a fluid. Now Maciej Gałka of the University of Cambridge and colleagues have taken a step in that direction by witnessing the onset of turbulence in a quantum gas and observing its evolution over roughly 100 ms [1]. The finding could help scientists answer open questions in turbulence, which is observed in systems ranging from ocean waves to star interiors.

Elon Musk doesn’t follow the same standards that most entrepreneurs do. He’s different, he likes to be different!

And when you’re different, and you’re not afraid to be, it’s okay to test a cigar (or should I say ‘joint’?) of tobacco mixed with marijuana, on Joe Rogan’s famous podcast. But if you look closely, Elon was just nice (polite) and followed Rogan’s elaborate script. Before trying it, Musk even asked him if it was legal.

Then all those facial expressions of Musk, which photojournalists love to catch, go viral as if he’s there promoting some soft drug or passing abroad that his office at Tesla (or SpaceX) is enveloped in a large cloud of smoke.

Quite the opposite. The expressions themselves spoke for themselves, as if to say, “This is nothing special, Joe. Why do you waste my time with these scenes”? Musk even claimed that weed is not good for productivity at all, but it has nothing against (as I do, by the way).

Continue reading “From ‘Chief Twit’ to ‘Twitter Complaint Hotline Operator’” »

An international research team led by the University of Minnesota Twin Cities has measured the size of a star dating back 2 billion years after the Big Bang, or more than 11 billion years ago. Detailed images show the exploding star cooling and could help scientists learn more about the stars and galaxies present in the early universe. The paper is published in Nature.

“This is the first detailed look at a supernova at a much earlier epoch of the universe’s evolution,” said Patrick Kelly, a lead author of the paper and an associate professor in the University of Minnesota School of Physics and Astronomy. “It’s very exciting because we can learn in detail about an individual star when the universe was less than a fifth of its current age, and begin to understand if the stars that existed many billions of years ago are different from the ones nearby.”

The red supergiant in question was about 500 times larger than the sun, and it’s located at redshift three, which is about 60 times farther away than any other supernova observed in this detail.

Quantum chromodynamics (QCD) is one of the pillars of the Standard Model of particle physics. It describes the strong interaction – one of the four fundamental forces of nature. This force holds quarks and gluons – collectively known as partons – together in hadrons such as the proton, and protons and neutrons together in atomic nuclei. Two hallmarks of QCD are chiral symmetry breaking and asymptotic freedom. Chiral symmetry breaking explains how quarks generate the masses of hadrons and therefore the vast majority of visible mass in the universe. Asymptotic freedom states that the strong force between quarks and gluons decreases with increasing energy. The discovery of these two QCD effects garnered two Nobel prizes in physics, in 2008 and 2004, respectively.

High-energy collisions of lead nuclei at the Large Hadron Collider (LHC) explore QCD under the most extreme conditions on Earth. These heavy-ion collisions recreate the quark–gluon plasma (QGP): the hottest and densest fluid ever studied in the laboratory. In contrast to normal nuclear matter, the QGP is a state where quarks and gluons are not confined inside hadrons. It is speculated that the universe was in a QGP state around one millionth of a second after the Big Bang.

The ALICE experiment was designed to study the QGP at LHC energies. It was operated during LHC Runs 1 and 2, and has carried out a broad range of measurements to characterise the QGP and to study several other aspects of the strong interaction. In a recent review, highlights of which are described below, the ALICE collaboration takes stock of its first decade of QCD studies at the LHC. The results from these studies include a suite of observables that reveal a complex evolution of the near-perfect QGP liquid that emerges in high-temperature QCD. ALICE measurements also demonstrate that charm quarks equilibrate extremely quickly within this liquid, and are able to regenerate QGP-melted “charmonium” particle states. ALICE has extensively mapped the QGP opaqueness with high-energy probes, and has directly observed the QCD dead-cone effect in proton–proton collisions. Surprising QGP-like signatures have also been observed in rare proton–proton and proton–lead collisions.