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The organoids can be used to study the development of diseases and the effects of drugs.

Michael Helmrath, a pediatric surgeon at Cincinnati Children’s Hospital Medical Center, and his colleagues made headlines last week when they revealed trials where they had transplanted balls of human intestinal tissue into mice, according to a report by *Wired* published on Thursday.

After a few weeks, these transplants developed key features of the human immune system, introducing a model that could be used to effectively simulate the human intestinal system.

It’s not the first time researchers at Cincinnati Children’s make such an advancement in organoids (miniature replicas of human organs). In 2010, the institution became the first in the world to create a working intestinal organoid. ## Containing human cells

Since organoids contain human cells and exhibit some of the same structures and functions as real organs, scientists everywhere are using them to study how organs develop, how diseases occur and how drugs work.

“It’s incredibly important that when we are trying to create these platforms for testing drug efficacy and drug side effects in human tissue models that we actually make sure that we are as close to, and as complete as, the tissue in which the drug will work eventually in our human body. So, adding the immune system is an important part of that,” told *Wired* Pradipta Ghosh, director of the Humanoid Center of Research Excellence at the University of California San Diego School, which is engineering human organoids to test drugs. Ghosh was not part of the new study.

Helmrath and his team started with induced pluripotent stem cells, which can turn into any type of body tissue, and fed them a specific molecular cocktail to coax them into transforming into intestinal cells. They ended up with some organoid spheres that the team then carefully transplanted into mice.

The Tesla transformation to a fully integrated design.


Join me and Cory Steuben as he reviews all the different ways Tesla has an advantage over their competitors from manufacturing, the factories, the business model and the team.

Between, Cory, Sandy and the other associates at Munro & Associates they are likely the best in the planet who knows the most about how different cars are made and about the auto industry and the competition in the auto industry.

Cory is the President of Munro & Associates who is the de facto leader in reverse engineering and teardown benchmarking. They tear down all sorts of cars and they know every single part and every single price, the supply chain and what it takes to manufacture these parts.

Cory Steuben on Twitter:@corysteuben.

The “one-shot” process paves the path for cutting-edge 3D cell culture methods with biomedical engineering applications, claim the scientists.

German scientists have created a new technology that helps them print 3D objects with sound waves.

The design creates pressure fields using several acoustic holograms, which can be used to print solid particles, gel beads, and even living cells, according to the study released on Thursday.


Carloscastilla/iStock.

The new method of 3D matter assembly was developed by researchers from the Institute for Molecular Systems Engineering and Advanced Materials and the Micro, Nano, and Molecular Systems Lab at the Max Planck Institute for Medical Research at Heidelberg University.

A new North Carolina State University study, performed in collaboration with battery testing researchers at the U.S. Department of Energy’s Oak Ridge National Laboratory, shows that extremely short pulses from a high-powered laser can cause tiny defects in lithium-ion battery materials—defects that can enhance battery performance.

The technique, called nanosecond pulsed laser annealing, lasts for only 100 nanoseconds and is generated by the same type of laser used in modern-day eye surgeries. Researchers tested the technique on graphite, a material widely used in lithium-ion battery anodes, or positive electrodes. They tested the technique in batches of 10 pulses and 80 pulses and compared the differences in current capacity; power is calculated by multiplying voltage by current.

Lithium-ion batteries are widely used in portable electronic devices and electric cars. With further improvements, these batteries could have a major impact on transportation and as storage devices for renewable energy sources like wind and solar.

When Srikanth Singamaneni and Guy Genin, both professors of mechanical engineering and materials science at the McKelvey School of Engineering at Washington University in St. Louis, established a new collaboration with researchers from the School of Medicine in late 2019, they didn’t know the landscape of infectious disease research was about to shift dramatically. In a conference room overlooking Forest Park on a beautiful fall day, the team had one goal in mind: tackle the biggest infectious disease problem facing the world right then.

“Srikanth and I had a vision of a simple, quantitative diagnostic tool, so we connected with infectious physicians here at WashU and asked them, ‘What are the most important questions that could be answered if you could get really detailed information cheaply at the point of care?’” said Genin, the Harold and Kathleen Faught Professor of Mechanical Engineering.

“Greg Storch told us that one of the most important challenges facing the field of infectious disease is finding a way to figure out quickly if a patient has a and should get antibiotics or has a viral infection, for which antibiotics will not be effective.”

Scientists at the University of Connecticut Health, Yale University, and Johns Hopkins University have discovered that certain cancer cells possess the ability to evade limitations caused by oxygen deprivation, enabling the cancer cells to continue to grow.

The findings were recently published in the journal Cell Systems. The research was led by Kshitiz, an assistant professor in the Department of Biomedical Engineering, in collaboration with scientists Chi V. Dang from Johns Hopkins and Andre Levchenko from Yale.

Nearly a decade ago, the researchers observed a strange phenomenon while looking at cancer cells under hypoxia—or a lack of oxygen.

Pilonnel noticed that millions watch his videos, but very few actually attempt them. He wants to help people by making replacement parts available.

Users of Apple’s AirPods are well aware that the product they purchased is pretty much disposable. Once the rechargeable battery on the device gives way, there is no way to replace them; you need to buy new AirPods, unless you are ready to do the hard work yourself, with a little help, of course.

Ken Pillonel is no stranger to toying with Apple products. As an engineering student, he built the world’s first iPhone with a USB-C port and has previously shown us how the batteries in the AirPods can be replaced if you can 3D-print a new case.


Exploring the Simulation/YouTube.

The best part of Pillonel’s mods is that everything is published in GitHub repositories, and one only needs to spend some time going through the notes to get the desired changes.

I will gladly pay you Tuesday for a hamburger today.


After a long day, you are finally at your favorite restaurant and you order the burger you have been dreaming of the whole time. The burger is gone within minutes, or seconds depending on your appetite. You call the waiter to send compliments to the chef for that delicious burger but are surprised to learn that your burger’s meat has been grown in a laboratory. How would you feel about eating lab-grown meat? Would you even care or does this scenario not make sense because you would have understood in the first bite that you are not eating “real meat”? What is lab-grown meat, anyway?

Lab-grown meat is made from animal cells, so technically, it is real meat. We can even say that cultured meat is more genuine than a plant-based one. When you consider the rapidly growing world population, resources spent on breeding the animals don’t seem sustainable in the long run at all. With all things considered, lab-grown meat might be the safest and most sustainable option for our future and might become a big part of our lives. In fact, even now, world-leading scientists and entrepreneurs are investing in lab-grown meat research to make it both affordable and delicious.

Even though it may feel a little unconventional at first, laboratory-grown meat can be the key to sustainability and meeting the meat demand without disturbing the natural balance. If you are skeptical about meat made in the laboratory and want to know how lab-grown meat is made, this video can answer all your questions!

To get the latest science and technology news, subscribe to our newsletter “The Blueprint” at https://bit.ly/3BDdN5e.

The company hopes to make the new cars part of the Olympic sport.

Australia-based company Airspeeder, which engineered the world’s first flying electric racing car, is now training its electric pods to be part of the Olympic sport one day.

Airspeeder is flying racing pods which it hopes could be a demonstration sport at Brisbane Olympics 2032, according to a report by ABC News published on Friday.

“It is the future, it is pod racing in the sky… it’s Star Wars,” the company’s head of media Stephen Sidlo told ABC News.


Interesting Engineering is a cutting edge, leading community designed for all lovers of engineering, technology and science.

Juan Andres Guerrero-Saade’s speciality is picking apart malicious software to see how it attacks computers.

It’s a relatively obscure cybersecurity field, which is why last month he hosted a weeklong seminar at Johns Hopkins University where he taught students the complicated practice of reverse engineering malware.

Several of the students had little to no coding background, but he was confident a new tool would make it less of a challenge: He told the students to sign up for ChatGPT.

“Programming languages are languages,” Guerrero-Saade, an adjunct lecturer at Johns Hopkins, said, referring to what the ChatGPT software does. “So it has become an amazing tool for prototyping things, for getting very quick, boilerplate code.”


YouTube and TikTok are already rife with videos of people showing how they’ve found ways to have ChatGPT perform tasks that once required a hefty dose of coding ability.