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The ideal material for interfacing electronics with living tissue is soft, stretchable, and just as water-loving as the tissue itself—in short, a hydrogel. Semiconductors, the key materials for bioelectronics such as pacemakers, biosensors, and drug delivery devices, on the other hand, are rigid, brittle, and water-hating, impossible to dissolve in the way hydrogels have traditionally been built.

A paper published today in Science from the UChicago Pritzker School of Molecular Engineering (PME) has solved this challenge that has long stymied researchers, reimagining the process of creating hydrogels to build a powerful semiconductor in hydrogel form. Led by Asst. Prof. Sihong Wang’s research group, the result is a bluish gel that flutters like a sea jelly in water but retains the immense semiconductive ability needed to transmit information between living tissue and machine.


New material from the UChicago Pritzker School of Molecular Engineering can create better brain-machine interfaces, biosensors, and pacemakers.

For the first time, a team of researchers at Lawrence Livermore National Laboratory (LLNL) quantified and rigorously studied the effect of metal strength on accurately modeling coupled metal/high explosive (HE) experiments, shedding light on an elusive variable in an important model for national security and defense applications.

The team used a Bayesian approach to quantify with tantalum and two common explosive materials and integrated it into a coupled metal/HE . Their findings could lead to more accurate models for equation-of-state-studies, which assess the state of matter a material exists in under different conditions. Their paper —featured as an editor’s pick in the Journal of Applied Physics —also suggested that metal strength uncertainty may have an insignificant effect on result.

“There has been a long-standing field lore that HE model calibrations are sensitive to the metal strength,” said Matt Nelms, the paper’s first author and a group leader in LLNL’s Computational Engineering Division (CED). “By using a rigorous Bayesian approach, we found that this is not the case, at least when using tantalum.”

Researchers at the University of Kentucky are exploring new ways to use nanoparticles in combination with other materials as an innovative approach to cancer therapy.

The paper titled “Iron Oxide Nanozymes Enhanced by Ascorbic Acid for Macrophage-Based Cancer Therapy” was published earlier this year in Nanoscale.

Sheng Tong, Ph.D., an associate professor in the F. Joseph Halcomb II, M.D., Department of Biomedical Engineering in the UK Stanley and Karen Pigman College of Engineering, led the study.

Random noise, such as background hubbub on a phone call, is usually thought of as unwanted interference. Now researchers at Columbia Engineering find the brain may harness unavoidable random fluctuations of its activity to perform useful computations, particularly in tasks relying on memory.

These findings not only deepen our understanding of how the brain works, but also may provide a blueprint for building smarter, more resilient technologies, the research team says.

They detailed their findings Jan. 16 in the Proceedings of the National Academy of Sciences.

Tune Therapeutics, a Durham biotechnology startup co-founded by a Duke professor, announced the completion of its Series B fundraising round on Jan. 12, in which it raised $175 million to support clinical trials for its epigenome editor.

The company will use the funding to advance clinical trials for Tune-401, the epigenetic silencing drug for treating chronic Hepatitis B — a viral infection that damages the liver and affects millions globally. The investment will also support the development of various other therapies, including additional gene, cell and regenerative therapy programs.

“The goal is to epigenetically repress the virus to prevent it from being able to replicate and make the viral proteins that it would normally produce,” said Charles Gersbach, John W. Strohbehn distinguished professor of biomedical engineering and cofounder of Tune Therapeutics.

The idea of traveling through interstellar space using spacecraft propelled by ultrathin sails may sound like the stuff of sci-fi novels. But in fact, a program started in 2016 by Stephen Hawking and Yuri Milner, known as the Breakthrough Starshot Initiative, has been exploring the idea. The concept is to use lasers to propel miniature space probes attached to “lightsails” to reach ultrafast speeds and eventually our nearest star system, Alpha Centauri.

Caltech is leading the worldwide community working toward achieving this audacious goal.

“The will travel faster than any previous spacecraft, with potential to eventually open interstellar distances to direct spacecraft exploration that are now only accessible by remote observation,” explains Harry Atwater, the Otis Booth Leadership Chair of the Division of Engineering and Applied Science and the Howard Hughes Professor of Applied Physics and Materials Science at Caltech.

A team of researchers from Universidad Carlos III de Madrid (UC3M) has developed an innovative technique that allows the production of regular oil lenses of uniform size on the surface of water in a simple and reproducible fashion. The technique will facilitate the study of the behavior of oily substances dispersed on water surfaces.

This discovery is crucial for understanding the dispersion of some liquids floating on water and could have many applications in oil spill mitigation and the food and textile industries. The study is published in the journal Physical Review Letters.

The initial discovery, according to the researchers, was the result of an “accident” during the preparation of a routine experiment. “We were trying to coat a water surface with a thin layer of oil, but the result was unexpected: Instead of a uniform film, we obtained a series of identical and very small droplets, which aroused our curiosity,” explains Javier Rodríguez, from UC3M’s Department of Thermal and Fluids Engineering.

A research team from Japan has developed a unified model to scale the transitional pressure development in a one-dimensional flow. This achievement provides a better understanding of how pressure fields build up in the confined fluid system for various acceleration situations, which might be applicable to biomechanics-related impact problems, such as human brain injuries caused by physical contact.

Liquid is usually not considered compressible, except for when subjected to a high-speed flow or rapid acceleration. The latter case is known as the water hammer theory, which often occurs with a loud sound when a water faucet is suddenly closed.

In recent years, the onset of mild traumatic brain injury has been discussed in a similar context, meaning that better understanding of this issue is important in not only traditional engineering but also emerging biomechanics applications.

A team of stem cell scientists have successfully used embryonic stem cell engineering to create a bi-paternal mouse—a mouse with two male parents—that lived until adulthood.

Their results, published on January 28, 2025, in Cell Stem Cell, describe how targeting a particular set of genes involved in reproduction allowed the researchers to overcome previously insurmountable challenges in unisexual reproduction in mammals.

Scientists have attempted to create bi-paternal mice before, but the embryos developed only to a certain point and then stopped growing. Here, the investigators, led by corresponding author Wei Li of the Chinese Academy of Sciences (CAS) in Beijing, focused on targeting imprinting genes, which regulate in a number of ways.