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Dressed to kill: Tailoring a suit for tumor-penetrating cancer meds

Very cool.


For more than a decade, biomedical researchers have been looking for better ways to deliver cancer-killing medication directly to tumors in the body. Tiny capsules, called nanoparticles, are now being used to transport chemotherapy medicine through the bloodstream, to the doorstep of cancerous tumors. But figuring out the best way for the particles to get past the tumor’s “velvet rope” and enter the tumor is a challenge scientists are still working out. Drexel University researchers believe that the trick to gaining access to the pernicious cellular masses is to give the nanoparticles a new look—and that dressing to impress will be able to get them past the tumor’s biological bouncers.

Targeted cancer therapy is most effective when the medication is released as close as possible to the interior of a , to increase its odds of penetrating and killing off cancerous cells. The challenge that has faced cancer researchers for years is making a delivery vehicle that is sturdy enough to safely get the medication through the bloodstream to tumors—which is no smooth ride—but is also lithe enough to squeeze through the tumor’s dense extra cellular space—a matrix stuffed with sugars called hyaluronic acid.

In research recently published in the journal Nano Letters, lead author Hao Cheng, PhD, an assistant professor with an appointment in Drexel’s College of Engineering, and affiliation with School of Biomedical Engineering, Science and Health Systems; reports that the way to get past the tumor’s front door has everything to do with how the tiny particle is suited up for the journey.

Crumpling approach enhances photodetectors’ light responsivity

HUGE deal for wearables and biomed technologies.


Researchers from the University of Illinois at Urbana-Champaign have demonstrated a new approach to modifying the light absorption and stretchability of atomically thin two-dimensional (2D) materials by surface topographic engineering using only mechanical strain. The highly flexible system has future potential for wearable technology and integrated biomedical optical sensing technology when combined with flexible light-emitting diodes.

“Increasing graphene’s low light absorption in visible range is an important prerequisite for its broad potential applications in photonics and sensing,” explained SungWoo Nam, an assistant professor of mechanical science and engineering at Illinois. “This is the very first stretchable photodetector based exclusively on graphene with strain-tunable photoresponsivity and wavelength selectivity.”

Graphene—an atomically thin layer of hexagonally bonded carbon atoms—has been extensively investigated in advanced photodetectors for its broadband absorption, high carrier mobility, and mechanical flexibility. Due to graphene’s low optical absorptivity, graphene photodetector research so far has focused on hybrid systems to increase photoabsorption. However, such hybrid systems require a complicated integration process, and lead to reduced carrier mobility due to the heterogeneous interfaces.

Advance may make quantum computing more practical

Very nice; we’re getting closer.


But superposition is fragile, and finding ways to preserve it is one of the chief obstacles to developing large, general-purpose quantum computers. In today’s Nature, MIT researchers describe a new approach to preserving superposition in a class of quantum devices built from synthetic diamonds. The work could ultimately prove an important step toward reliable quantum computers.

In most engineering fields, the best way to maintain the stability of a physical system is feedback control. You make a measurement — the current trajectory of an airplane, or the temperature of an engine — and on that basis produce a control signal that nudges the system back toward its desired state.

The problem with using this technique to stabilize a quantum system is that measurement destroys superposition. So quantum-computing researchers have traditionally had to do without feedback.

International Petition against Autonomous Weapons

Stuart Russell received his B.A. with first-class honours in physics from Oxford University in 1982 and his Ph.D. in computer science from Stanford in 1986. He then joined the faculty of the University of California at Berkeley, where he is Professor (and formerly Chair) of Electrical Engineering and Computer Sciences and holder of the Smith-Zadeh Chair in Engineering. He is also an Adjunct Professor of Neurological Surgery at UC San Francisco and Vice-Chair of the World Economic Forum’s Council on AI and Robotics. He has published over 150 papers on a wide range of topics in artificial intelligence including machine learning, probabilistic reasoning, knowledge representation, planning, real-time decision making, multitarget tracking, computer vision, computational physiology, and global seismic monitoring. His books include “The Use of Knowledge in Analogy and Induction”, “Do the Right Thing: Studies in Limited Rationality” (with Eric Wefald), and “Artificial Intelligence: A Modern Approach” (with Peter Norvig).

Abstract:

Autonomous weapons systems select and engage targets without human intervention; they become lethal when those targets include humans. LAWS might include, for example, armed quadcopters that can search for and eliminate enemy combatants in a city, but do not include cruise missiles or remotely piloted drones for which humans make all targeting decisions. The artificial intelligence (AI) and robotics communities face an important ethical decision: whether to support or oppose the development of lethal autonomous weapons systems (LAWS).

ORNL 20kW wireless charging system hits 90% efficiency

Oak Ridge National Laboratory (ORNL) has been working on a wireless charging system for EVs and plug-in hybrids for years. The goal is to create a system that makes charging EVs and hybrids easier for drivers and to make EVs and other plug-in vehicles as cheap and easy to own as a gasoline vehicle. ORNL has announced that it has demonstrated a 20-kilowatt wireless charging system that has achieved 90% efficiency at three times the rate of the plug-in systems commonly used in electric cars today.

ORNL has multiple industry partners that are participating in this program including Toyota, Cisco Systems, Evatran, and Clemson University International Center for Automotive Research. “We have made tremendous progress from the lab proof-of-concept experiments a few years ago,” said Madhu Chinthavali, ORNL Power Electronics Team lead. “We have set a path forward that started with solid engineering, design, scale-up and integration into several Toyota vehicles. We now have a technology that is moving closer to being ready for the market.”

The wireless charging system includes ORNL-built inverter, isolation transformer, vehicle-side electronics and coupling technologies, and it was built in under three years. The demonstrator system is integrated into a Toyota RAV4 with a 10kW battery. The next goal for the researchers is to create a 50kW wireless charging system that can match the power of commercially available quick plug-in chargers. These higher power-charging systems are essential for charging larger electrified vehicles like buses and trucks.

Researchers have worked out how to mind control cockroaches

In a video presented at IEEE Robotics and Automation Society’s annual conference, Chinese engineering students guide a living cockroach along S-shaped and Z-shaped paths using brain-to-brain interface: a bluetooth electroencephalogram (EEG) headset, translated and wirelessly sent to an electronic backpack receiver attached to the cockroach. The electrical impulses then stimulated the antennae nerves of the cockroach through a microelectrode implanted into its head. Watch the video released:

(Announced 16 June 2015 but only just came to our attention. And no, this is not April Fools post.)

Successfully Engineering Water-loving Nanoparticle Diodes

Nanoparticle diodes and devices that work when wet.

“Groundbreaking” research by Prof. Bartosz Grzybowski (School of Natural Science).
Nanoparticle Diodes and Devices That Work When Wet.

A new study by an international team of researchers, affiliated with UNIST has found a new way to produce electronic devices, such as diodes, logic gates, and sensors without the need of semiconductors.

In their study, published in the current edition of Nano Technology, the team reported that they used metal nanoparticles, coated with charged organic ligands to create versatile electronic circuits, which they have named “chemoelectronic” circuits.

A programming language for living cells

MIT biological engineers have created a programming language that allows them to rapidly design complex, DNA-encoded circuits that give new functions to living cells.

Using this language, anyone can write a program for the function they want, such as detecting and responding to certain . They can then generate a DNA sequence that will achieve it.

“It is literally a for bacteria,” says Christopher Voigt, an MIT professor of biological engineering. “You use a text-based language, just like you’re programming a computer. Then you take that text and you compile it and it turns it into a DNA sequence that you put into the cell, and the circuit runs inside the cell.”

An Update on fast Transit Routing with Transfer Patterns | Google Research Blog

“What is the best way to get from A to B by public transit? Google Maps is answering such queries for over 20,000 cities and towns in over 70 countries around the world, including large metro areas like New York, São Paulo or Moscow, and some complete countries, such as Japan or Great Britain.”

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