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Category: engineering – Page 131

Scientists uncover new information about cellular death process, previously thought to be irreversible

A study published by researchers at the University of Illinois Chicago describes a new method for analyzing pyroptosis–the process of cell death that is usually caused by infections and results in excess inflammation in the body–and shows that process, long thought to be irreversible once initiated, can in fact be halted and controlled.

The discovery, which is reported in Nature Communications, means that scientists have a new way to study diseases that are related to malfunctioning cell death processes, like some cancers, and infections that can be complicated by out-of-control inflammation caused by the process. These infections include sepsis, for example, and acute respiratory distress syndrome, which is among the major complications of COVID-19 illness.

Pyroptosis is a series of biochemical reactions that uses gasdermin, a protein, to open large pores in the cell membrane and destabilize the cell. To understand more about this process, the UIC researchers designed an “optogenetic” gasdermin by genetically engineering the protein to respond to light.

“The cell death process plays an important role in the body, in both healthy states and unhealthy ones, but studying pyroptosis–which is a major type of cell death–has been challenging,” said Gary Mo, UIC assistant professor in the department of pharmacology and regenerative medicine and the department of biomedical engineering at the College of Medicine.

Mo said that methods to examine the pyroptosis mechanisms at play in live cells are difficult to control because they are initiated by unpredictable pathogens, which in turn have disparate effects in different cells and people.

“Our optogenetic gasdermin allowed us to skip over the unpredictable pathogen behavior and the variable cellular response because it mimics at the molecular level what happens in the cell once pyroptosis is initiated,” Mo said.

The researchers applied this tool and used florescent imaging technology to precisely activate gasdermin in cell experiments and observe the pores under various circumstances. They discovered that certain conditions, like specific concentrations of calcium ions, for example, triggered the pores to close within only tens of seconds.

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A better black hole laser may prove a circuitous ‘Theory of Everything’

😮 circa 2021.

The fundamental forces of physics govern the matter comprising the Universe, yet exactly how these forces work together is still not fully understood. The existence of Hawking radiation — the particle emission from near black holes — indicates that general relativity and quantum mechanics must cooperate. But directly observing Hawking radiation from a black hole is nearly impossible due to the background noise of the Universe, so how can researchers study it to better understand how the forces interact and how they integrate into a “Theory of Everything”?

According to Haruna Katayama, a doctoral student in Hiroshima University’s Graduate School of Advanced Science and Engineering, since researchers cannot go to the Hawking radiation, Hawking radiation must be brought to the researchers. She has proposed a quantum circuit that acts as a black hole laser, providing a lab-bench black hole equivalent with advantages over previously proposed versions. The proposal was published on Sept. 27 Scientific Reports.

“In this study, we devised a quantum-circuit laser theory using an analogue black hole and a white hole as a resonator,” Katayama said.

Scientists reduce all-solid-state battery resistance

All-solid-state batteries are now one step closer to becoming the powerhouse of next-generation electronics, as researchers from Tokyo Tech, National Institute of Advanced Industrial Science and Technology (AIST), and Yamagata University introduce a strategy to restore their low electrical resistance. They also explore the underlying reduction mechanism, paving the way for a more fundamental understanding of the workings of all-solid-state lithium batteries.

All-solid-state lithium batteries have become the new craze in and engineering as conventional lithium-ion batteries can no longer meet the standards for advanced technologies, such as electric vehicles, which demand high energy densities, fast charging, and long cycle lives. All-solid-state batteries, which use a instead of a liquid electrolyte found in traditional batteries, not only meet these standards but are comparatively safer and more convenient as they have the possibility to charge in a short time.

However, the solid electrolyte comes with its own challenge. It turns out that the interface between the positive electrode and solid electrolyte shows a large electrical whose origin is not well understood. Furthermore, the resistance increases when the electrode surface is exposed to air, degrading the battery capacity and performance. While several attempts have been made to lower the resistance, none have managed to bring it down to 10 Ω cm2 (ohm centimeter-squared), the reported interface resistance value when not exposed to air.

Changing the properties of ferroelectric materials

Researchers in the Technion Department of Materials Science and Engineering have succeeded in changing a material’s electrical properties by vacating an oxygen atom from the original structure. Possible applications include electronic-device miniaturization and radiation detection.

What do ultrasound imaging of a fetus, cellular mobile communication, micro motors, and low-energy-consumption computer memories have in common? All of these technologies are based on ferroelectric materials, which are characterized by a strong correlation between their atomic and the electrical and mechanical properties.

Technion–Israel Institute of Technology researchers have succeeded in changing the properties of ferroelectric materials by vacating a single from the original structure. The breakthrough could pave the way for the development of new technologies. The research was headed by Assistant Professor Yachin Ivry of the Department of Materials Science and Engineering, accompanied by postdoctoral researcher Dr. Hemaprabha Elangovan and Ph.D. student Maya Barzilay, and was published in ACS Nano. It is noted that engineering an individual oxygen vacancy poses a considerable challenge due to the light weight of oxygen .

Harnessing programming techniques to improve R scripts

Automating repetitive tasks with loops and functions.

Many R users get into R programming from a statistics background rather than a programming/software engineering background, having previously used software such as SPSS, Excel etc. As such they may not have an understanding of some of the programming techniques that can be leveraged to improve code. This can include making the code more modular which in turn makes it easier to find and resolve bugs, but also can be used to automate repetitive tasks, such as producing tables and plots etc.

This short post in c ludes some of the basic programming techniques that can be used to improve the quality and maintainability of R scripts. This will also save you a whole lot of time if you are carrying out repetitive tasks that are only marginally different. We assume that you have a basic understanding of writing simple scripts in R.

Let’s start with a simple example. Let’s say we have some data from several different groups. In this case 3 animals (tigers, swans and badgers) and we have collected some data on relating to this (a score and value of some kind).

Still Nervous about JWST? Friday and Saturday’s Sunshield Deployments will be Nail-biters

Every part of the James Webb Space Telescope’s (JWST’s) deployment is nerve-wracking, but some of the most nail-biting moments will happen on New Year’s Eve and New Year’s Day.

We’re on Day 5 of the Webb Telescope’s 30 Days of Terror, and so far, the observatory’s engineering team has successfully checked off all the boxes on its to-do list (get your own check-off list here.)

But starting on December 31 comes the task that is among the most worrisome: unfolding the giant sunshield. The enormous sunshield is about 70 by 47 feet (21 by 14 meters) when deployed, or approximately the size of a tennis court.

Kyoto University Loses 77 Terabytes of Research Data After Supercomputer Backup Error

Unfortunately, some of the data is lost forever. 🧐

#engineering

A routine backup procedure meant to safeguard data of researchers at Kyoto University in Japan went awry and deleted 77 terabytes of data, Gizmodo reported. The incident occurred between December 14 and 16, first came to light on the 16th, and affected as many as 14 research groups at the university.

Supercomputers are the ultimate computing devices available to researchers as they try to answer complex questions on a range of topics from molecular modeling to oil exploration, climate change models to quantum mechanics, to name a few. Capable of making hundred quadrillion operations a second, these computers are not only expensive to build but also to operate, costing hundreds of dollars for every hour of operation.

According to Bleeping Computer that originally reported the mishap, the university uses Cray supercomputers with the top system employing 122,400 computing cores. The memory on the system though is limited to approximately 197 terabytes and therefore, an Exascaler data storage system is used, which can transfer 150 GB of data per second and store up to 24 petabytes of information.

Raytheon To Enhance Seasparrow Missiles For US Navy That Can Defend NATO Vessels Against Missile & Drone Attacks

Defense company Raytheon has clinched a US Navy contract to provide engineering and technical services for the Evolved Seasparrow Missile and NATO Seasparrow Missile programs, the Pentagon has said.

A press release by the Department of Defense on December 30 stated, “Raytheon Company [of] Tucson, Arizona, is awarded a $55,121,826 modification to a previously awarded contract for engineering and technical services in support of the Evolved Seasparrow Missile and NATO Seasparrow Missile Systems programs.”

The contract combines purchases for the US government (99%); and those of Japan and the United Arab Emirates (1%) under the Foreign Military Sales program.

Plant Scientists Find Recipe for Anti-Cancer Compound in Herbs Like Thyme and Oregano

Thyme and oregano possess an anti-cancer compound that suppresses tumor development, but adding more to your tomato sauce isn’t enough to gain significant benefit. The key to unlocking the power of these plants is in amplifying the amount of the compound created or synthesizing the compound for drug development.

Researchers at Purdue University achieved the first step toward using the compound in pharmaceuticals by mapping its biosynthetic pathway, a sort of molecular recipe of the ingredients and steps needed.

“These plants contain important compounds, but the amount is very low and extraction won’t be enough,” said Natalia Dudareva, a Distinguished Professor of Biochemistry in Purdue’s College of Agriculture, who co-led the project. “By understanding how these compounds are formed, we open a path to engineering plants with higher levels of them or to synthesizing the compounds in microorganisms for medical use.