Lifeboat Foundation

In a new study published in Cell Stem Cell, a team led by USC Stem Cell scientist Michael Bonaguidi, Ph.D., demonstrates that neural stem cells—the stem cells of the nervous system—age rapidly.

“There is chronological aging, and there is biological aging, and they are not the same thing,” said Bonaguidi, an Assistant Professor of Stem Cell Biology and Regenerative Medicine, Gerontology and Biomedical Engineering at the Keck School of Medicine of USC. “We’re interested in the biological aging of neural stem cells, which are particularly vulnerable to the ravages of time. This has implications for the normal cognitive decline that most of us experience as we grow older, as well as for dementia, Alzheimer’s disease, epilepsy and brain injury.”

In the study, first author Albina Ibrayeva, a Ph.D. candidate in the Bonaguidi Lab in the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, joined her colleagues in looking at the brains of young, middle-aged and old mice.

In recent years, electronics engineers worldwide have been trying to develop new semiconductor heterostructure devices using atomically thin materials. Among the many devices that can be fabricated using these materials are resonant tunneling diodes, which typically consist of a quantum-well structure placed between two barrier layers.

Past research has shown that stacking two-dimensional (2D) layers that are twisted in relation to each other can enhance or suppress the interlayer coupling at their interface. This suppression or enhancement can in turn modulate the electronic, optical and mechanical properties of the resulting device.

For instance, some studies found that the intralayer current transport in small angle twisted bilayer graphene prompted some exotic phenomena, such as superconductivity and ferromagnetism. These observations inspired a fundamentally new approach to device engineering, known as ‘twistronics’ (i.e., twist electronics).

Circa 2017

When surgeons complete a successful lung operation, everyone should breathe a sigh of relief. But real relief may not come until weeks or even months later, when doctors remove the patient’s lingering sutures or staples. And that’s assuming there were no leakages, which can send a patient right back to the hospital.

Nasim Annabi, assistant professor of chemical engineering, has a better solution: a new type of surgical glue that could replace the need for staples and sutures altogether. Annabi is leading the research, which she and her colleagues from the University of Sydney and Harvard Medical School described in a paper published Wednesday in Science Translational Medicine.

Continue reading “Researchers develop surgical glue that seals wounds in seconds” »

What’s New: Intel today announced that it has signed an agreement with Defense Advanced Research Projects Agency (DARPA) to perform in its Data Protection in Virtual Environments (DPRIVE) program. The program aims to develop an accelerator for fully homomorphic encryption (FHE). Microsoft is the key cloud ecosystem and homomorphic encryption partner leading the commercial adoption of the technology once developed by testing it in its cloud offerings, including Microsoft Azure and the Microsoft JEDI cloud, with the U.S. government. The multiyear program represents a cross-team effort across multiple Intel groups, including Intel Labs, the Design Engineering Group and the Data Platforms Group, to tackle “the final frontier” in data privacy, which is computing on fully encrypted data without access to decryption keys.

“Fully homomorphic encryption remains the holy grail in the quest to keep data secure while in use. Despite strong advances in trusted execution environments and other confidential computing technologies to protect data while at rest and in transit, data is unencrypted during computation, opening the possibility of potential attacks at this stage. This frequently inhibits our ability to fully share and extract the maximum value out of data. We are pleased to be chosen as a technology partner by DARPA and look forward to working with them as well as Microsoft to advance this next chapter in confidential computing and unlock the promise of fully homomorphic encryption for all.” – Rosario Cammarota, principal engineer, Intel Labs, and principal investigator, DARPA DPRIVE program

I’ll believe it when I see it. But this is a skyhook which can be made with existing materials.

With one end of a steel cable hovering in Earth’s orbit and the other end somewhere in outer space, the concept of a futuristic floating “space elevator” promises to amplify humans’ ability to explore the universe — and scientists engineering an improved take on the 19th-century idea say the one-time fantasy is close to becoming a reality.

“Technical-wise, it’s kind of ready,” said George Zhu, a professor of mechanical engineering at York University and a coauthor of a new study on the idea. “It just has small engineering [adjustments], and there’s no fundamental difficulty to do that.”

Continue reading “Far from science fiction, space elevators may be nearing deployment” »

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Researchers with the CERN-based ALPHA collaboration have announced the world’s first laser-based manipulation of antimatter, leveraging a made-in-Canada laser system to cool a sample of antimatter down to near absolute zero. The achievement, detailed in an article published today and featured on the cover of the journal Nature, will significantly alter the landscape of antimatter research and advance the next generation of experiments.

Antimatter is the otherworldly counterpart to matter; it exhibits near-identical characteristics and behaviors but has opposite charge. Because they annihilate upon contact with matter, antimatter atoms are exceptionally difficult to create and control in our world and had never before been manipulated with a laser.

Continue reading “Researchers achieve world’s first manipulation of antimatter” »

New concept delivers continuous electricity with an approach that reduces cost and risk

San Diego, March 29, 2021 – Fusion energy is heating up. In the past few months, both the U.S. Department of Energy’s (DOE) Fusion Energy Sciences Advisory Committee (FESAC) and the National Academies of Sciences, Engineering, and Medicine (NASEM) released reports calling for aggressive development of fusion energy in the U.S.

Now, scientists at the DIII-D National Fusion Facility have released a new design for a compact fusion reactor that can generate electricity and help define the technology necessary for commercial fusion power. The approach is based on the “Advanced Tokamak” concept pioneered by the DIII-D program, which enables a higher-performance, self-sustaining configuration that holds energy more efficiently than in typical pulsed configurations, allowing it to be built at a reduced scale and cost.

ENERGY!!! — Jose Luis Cordeiro, Engineer, Economist, Futurist, Transhumanist, Author, “The Death Of Death”

Dr. José Luis Cordeiro is an engineer, economist, futurist, transhumanist and author.

Continue reading “Dr. José Luis Cordeiro — Engineer, Economist, Futurist, Transhumanist, Author — ENERGY!!!” »

Circa 2013

One of the greatest aspirations of the human mind has been to realize machines that surpass its cognitive intelligence. The rapid expansion in computing power, about to exceed the equivalent of the human brain, has yet to produce such a machine. The article by Neftci et al. in PNAS (1) offers a refreshing and humbling reminder that the brain’s cognition does not arise from exacting digital precision in high-performance computing, but rather emerges from an extremely efficient and resilient collective form of computation extending over very large ensembles of sluggish, imprecise, and unreliable analog components. This observation, first made by John von Neumann in his final opus (2), continues to challenge scientists and engineers several decades later in figuring and reproducing the mechanisms underlying brain-like forms of cognitive computing.

Related developments are currently unfolding in collaborative initiatives engaging scientists and engineers, on a grander scale, in advancing neuroscience toward understanding the brain. In parallel with the Human Brain Project in Europe, the Brain Research through Advancing Innovative Neurotechnologies Initiative promises groundbreaking advances in enabling tools for revolutionizing neuroscience by developing nanotechnology to probe brain function at greatly increased spatial and temporal detail. Engineers are poised to contribute even further in revolutionizing such developments in neuroscience. In this regard it is helpful to relate the inquisitive nature of science—analysis—to the constructive power of engineering, synthesis.