Australian startup Synchron, backed by Bill Gates and Jeff Bezos, looks set to beat Elon Musk’s Neuralink to market with a safe, reliable brain-computer interface that any hospital can quickly install – without cutting a hole in your skull.
Here we address the important question of cross-talk between the mitochondria and cytosol. We show that the inner mitochondrial protein, MiNT, interacts with a protein on the outer mitochondrial membrane (mNT). This interaction occurs within the major outer membrane protein VDAC1. Inside the inner space of VDAC1, MiNT transfers its [2Fe-2S] clusters to mNT, which was shown to be a [2Fe-2S] cluster donor protein that donates its cluster(s) to apo-acceptor proteins residing in the cytosol. Hence, we suggest a pathway for transferring [2Fe-2S] clusters from inside the mitochondria to the cytosol.
Mitochondrial inner NEET (MiNT) and the outer mitochondrial membrane (OMM) mitoNEET (mNT) proteins belong to the NEET protein family. This family plays a key role in mitochondrial labile iron and reactive oxygen species (ROS) homeostasis. NEET proteins contain labile [2Fe-2S] clusters which can be transferred to apo-acceptor proteins. In eukaryotes, the biogenesis of [2Fe-2S] clusters occurs within the mitochondria by the iron–sulfur cluster (ISC) system; the clusters are then transferred to [2Fe-2S] proteins within the mitochondria or exported to cytosolic proteins and the cytosolic iron–sulfur cluster assembly (CIA) system. The last step of export of the [2Fe-2S] is not yet fully characterized. Here we show that MiNT interacts with voltage-dependent anion channel 1 (VDAC1), a major OMM protein that connects the intermembrane space with the cytosol and participates in regulating the levels of different ions including mitochondrial labile iron (mLI). We further show that VDAC1 is mediating the interaction between MiNT and mNT, in which MiNT transfers its [2Fe-2S] clusters from inside the mitochondria to mNT that is facing the cytosol. This MiNT–VDAC1–mNT interaction is shown both experimentally and by computational calculations. Additionally, we show that modifying MiNT expression in breast cancer cells affects the dynamics of mitochondrial structure and morphology, mitochondrial function, and breast cancer tumor growth. Our findings reveal a pathway for the transfer of [2Fe-2S] clusters, which are assembled inside the mitochondria, to the cytosol.
The idea that our mind could live on in another form after our physical body dies has been a recurring theme in science fiction since the 1950s. Recent television series such as Black Mirror and Upload, as well as some games, demonstrate our continued fascination with this idea. The concept is known as mind uploading.
Recent developments in science and technology are taking us closer to a time when mind uploading could graduate from science fiction to reality.
In 2016, BBC Horizon screened a programme called The Immortalist, in which a
Russian millionaire unveiled his plans to work with neuroscientists, robot builders and other experts to create technology that would allow us to upload our minds to a computer in order to live forever.
Continue reading “How uploading our minds to a computer might become possible” »
A new Microsoft internal presentation reveals the company’s long-term goal for Windows.
Microsoft has been increasingly moving Windows to the cloud on the commercial side with Windows 365, but the software giant also wants to do the same for consumers. In an internal “state of the business” Microsoft presentation from June 2022, Microsoft discuses building on “Windows 365 to enable a full Windows operating system streamed from the cloud to any device.”
The presentation has been revealed as part of the ongoing FTC v. Microsoft hearing, as it includes Microsoft’s overall gaming strategy and how that relates to other parts of the company’s businesses. Moving “Windows 11 increasingly to the cloud”… More.
Continue reading “Microsoft wants to move Windows fully to the cloud” »
Year 2022 😗😁
Foraging for fungi may not only mean mushrooms are on the menu. New research has shown that mushroom skins could provide a biodegradable alternative to some plastics used in batteries and computer chips, making them easier to recycle.
Researchers from the Johannes Kepler University in Austria were working on flexible and stretchable electronics, with a focus on sustainable materials to replace non-degradable materials, when they made their discovery, published in the journal Science Advances Friday.
Continue reading “Scientists have used mushrooms to make biodegradable computer chips” »
Engineers have been trying to devise increasingly efficient and low-cost methods to fabricate electronic components and devices on a large-scale. Recently, some studies explored the possibilities of creating electronics using solution processing techniques, which involve the deposition of materials with electrical properties from a solution onto a surface.
Researchers at Yonsei University and Sungkyunkwan University in South Korea recently fabricated wafer-scale transistor arrays based on the inorganic compound molybdenum-disulfide using a solution processing method. Their paper, published in Nature Electronics, could contribute to enabling the large-scale and low-cost fabrication of next-generation electronics.
“We have been working on solution-processed 2D nanomaterials for scalable electronic applications for years, yet satisfying both electronic performance and scalability based on solution-based approaches has been very challenging until now,” Joonhoon Kang and Jeong Ho Cho, co-authors of the paper, told Tech Xplore.
Researchers at the University of Cambridge have developed a novel computer memory design that could boost performance using less energy.
Cambridge scientists have developed a new prototype for computer memory that could make for faster chips that could hold up to 100 times more data. The system is made up of barium bridges between films of a disordered material.
As powerful as current computer technology can be, there are a few hard limits to it. Data is encoded into just two states – one or zero. And this data is stored and processed in different parts of a computer system, so it needs to be shuttled back and forth, which consumes energy and time.
But an emerging form of computer memory, known as resistive switching memory, is designed to be far more efficient. Rather than flipping a bit of information into one of two possible states, this new kind of memory can create a continuous range of states. This is done by applying an electrical current to certain types of materials, which causes their electrical resistance to become either stronger or weaker. A broad spectrum of these slight differences in electrical resistance creates a series of possible states to store data.
No matter the need, these tiny PCs are here to serve. I’ve used many small form factor PCs and most of what I’ve used pales in comparison to the Xulu XR1 Pro. This device is not only the smallest of the tiny PCs I’ve tried, but it’s also the most powerful.
The device itself measures a scant 3.5 × 3.5 inches and is only 2.5 inches tall, making it the smallest AMD Ryzen 7-powered PC ever built. Yes, it’s tiny. But it also offers six USB ports, one USB Type C port, two HDMI ports, and a headphone jack.
As far as price is concerned, the Xulu XR1 Pro will start at around $299 and max out at around $399. So not only does this tiny machine punch above its weight, but it’s also at a price point that makes it even more appealing. Having an AMD Ryzen 7 desktop machine at that price is a bargain…no matter the size.
Continue reading “This tiny PC punches way above its weight, and it’s cheaper than you think” »
Year 2013 Basically they found out water is quantum which could then be turned into a water quantum computer.
Water is vital to life as we know it, but there is still a great deal unknown when it comes to correctly modeling its properties. Now researchers have discovered room-temperature water may be even more bizarre than once suspected — quantum physics suggest its hydrogen atoms can travel surprisingly farther than before thought, report findings detailed in the Proceedings of the National Academy of Sciences.
Water is just made of two hydrogen atoms and an oxygen atom, but despite its apparent simplicity, liquid water displays a remarkable number of unusual properties, such as how it decreases in density upon freezing, and the existence of some 19 different forms of ice. Scientists traditionally ascribe water’s peculiar behavior to the hydrogen bond. Water is polar — partial electric charges separate within the molecule, leading to slightly positively charged hydrogen ends and a negatively charged oxygen middle. As such, the hydrogens in one water molecule can get attracted to the oxygen in another, a hydrogen bond that can help explain why water has such a high boiling point, for example.
All of water’s anomalies, together with its unquestionably vital role in climate and life on Earth, have led to intense research around the globe, but still much remains unknown about it. To shed light on water’s behavior, materials scientist Michele Ceriotti at the University of Oxford in England and his colleagues modeled how the atomic nuclei of water’s hydrogen might behave in a quantum way — that is, not like points as the above explanation of hydrogen bonding from classical physics would suggest, but as more delocalized, cloud-like objects.
Continue reading “Quantumness of water molecules might explain unexpected behaviors” »
