Lifeboat Foundation

The results of a human study carried out by an international research team have provided valuable new insights into the activity of the brain’s noradrenaline (NA) system, which has been a longtime target for medications to treat attention-deficit/hyperactivity disorder, depression, and anxiety. The study employed what the researchers claim is a groundbreaking methodology, developed to record real-time chemical activity from standard clinical electrodes implanted into the brain routinely for epilepsy monitoring.

The results offer up new insights into brain chemistry, which could have implications for a wide array of medical conditions, and also demonstrate use of the new strategy for acquiring data from the living human brain.

“Our group is describing the first ‘fast’ neurochemistry recorded by voltammetry from conscious humans,” said Read Montague, PhD, the VTC Vernon Mountcastle research professor at Virginia Tech, and director of the Center for Human Neuroscience Research and the Human Neuroimaging Laboratory of the Fralin Biomedical Research Institute at VTC. “This is a big step forward and the methodological approach was implemented completely in humans – after more than 11 years of extensive development.” Montague is senior, and co-corresponding author of the researchers’ published paper in Current Biology, which is titled “Noradrenaline tracks emotional modulation of attention in human amygdala.” In their paper the authors concluded, “By showing that neuromodulator estimates can be obtained from depth electrodes already in standard clinical use in the conscious human brain, our study opens the door to a new area of research on the neuromodulatory basis of human health and disease.”

Next generation sequencing is now essential for patients with metastatic biliary cancer given the identification of targetable pathways, including fibroblast growth factor receptor and isocitrate dehydrogenase 1, for which there are approved treatments. HER2 has emerged as a target in metastatic biliary cancer, with studies finding 5% to 15% of cancers positive for overexpression or gene amplification.

Investigators now report results of an industry-sponsored, phase 2 basket study (SGNTUC-019) testing the combination of tucatinib — a HER2 tyrosine kinase inhibitor — and trastuzumab in patients with HER2-positive advanced biliary cancer that progressed on first-line gemcitabine/cisplatin–based chemotherapy. Local testing for HER2 was permissible via immunohistochemistry, fluorescence in situ hybridization, or next generation sequencing of tissue or blood.

Of 30 patients, half were men, 77% were Asian, half had gallbladder primaries, and half had intrahepatic or extrahepatic cholangiocarcinomas. During a median follow-up of 10.8 months, the primary endpoint of antitumor response rate was 46.7%, and duration of response was 6 months. The median progression-free survival was 5.5 months; median overall survival was 15.5 months. Treatment-related grade 3 or 4 serious adverse events were uncommon and attributable to tucatinib in 10% of patients and to trastuzumab in 6.7%; grade 3 diarrhea occurred in 6.6%.

As it lay buried for two millennia, a fragment of glass gradually acquired a nanostructured surface that reflects light like a butterfly’s wings.

The ancient Roman city of Aquileia was situated close to Italy’s modern border with Slovenia. Over the centuries since its founding in 181 BCE, Aquileia suffered floods, earthquakes, sieges, and sackings. Little remains of this ancient city of 100,000 inhabitants, but archaeologists have uncovered relics from that early period. One such specimen is a glass shard discovered in 2012 on farmland in the outskirts of the modern city of Aquileia. The shard is striking in its coloration: an iridescent surface of deep blue and shiny gold atop a substrate of dark green. Now, after subjecting the shard to a string of chemical and physical tests, Giulia Guidetti of Tufts University, Massachusetts, and her collaborators have identified the origin of the shard’s appearance: a chemical transformation of the amorphous glass into a nanolayered material, a photonic crystal [1].

Glassmaking was invented independently by several Bronze Age civilizations (3300 BCE to 1,200 BCE), including those of ancient Egypt and the Indus Valley. Glass beads, vessels, and figurines remained luxury items until the Romans invented the technique of glassblowing in the first century CE. As blowing technology spread, glassware became cheaper and faster to produce in a greater variety of shapes. Items manufactured in the Roman Empire included jars for cosmetics, jugs for condiments, and cups for wine.

NOAA scientists investigating the stratosphere have found that in addition to meteoric ‘space dust,’ the atmosphere more than seven miles above the surface is peppered with particles containing a variety of metals from satellites and spent rocket boosters vaporized by the intense heat of re-entry.

The discovery is one of the initial findings from analysis of data collected by a high-altitude research plane over the Arctic during a NOAA Chemical Science Laboratory mission called SABRE, short for Stratospheric Aerosol processes, Budget and Radiative Effects. It’s the agency’s most ambitious and intensive effort to date to investigate aerosol particles in the stratosphere, a layer of the atmosphere that moderates Earth’s climate and is home to the protective ozone layer.

Using an extraordinarily sensitive instrument custom-built at NOAA in Boulder, Colorado, and mounted in the nose of a NASA WB-57 research aircraft, scientists found aluminum and exotic metals embedded in about 10 percent of sulfuric acid particles, which comprise the large majority of particles in the stratosphere. They were also able to match the ratio of rare elements they measured to special alloys used in rockets and satellites, confirming their source as metal vaporized from spacecraft reentering Earth’s atmosphere.

The limitless world of chemistry and how researchers investigate it.

Study finds that in worms, the HSN neuron uses multiple chemicals and connections to orchestrate egg-laying and locomotion over the course of several minutes.

A new MIT

MIT is an acronym for the Massachusetts Institute of Technology. It is a prestigious private research university in Cambridge, Massachusetts that was founded in 1861. It is organized into five Schools: architecture and planning; engineering; humanities, arts, and social sciences; management; and science. MIT’s impact includes many scientific breakthroughs and technological advances. Their stated goal is to make a better world through education, research, and innovation.

The molecular synthesizer once thought to be impossible to make is now quite a possibility due to this discovery with electron beams that can heal crystalline structures and also build objects from electron beams this could one day be amplified to create even food with light into matter electron beams. Also this could create even life or even rebirth a universe or planet or sun really eventually anything that is matter. Really it is a molecular assembler with nearly limitless applications.

Electron beams can be used to heal nano-fractures in crystals instead of causing further damage to them, as initially expected by researchers who now report their surprise findings. Used to power microscopes that examine the smallest materials in the universe, electron beams may also be able to be used to create novel microstructures one atom at a time.

A feat once thought impossible, researchers at the University of Minnesota Twin Cities (UMN) behind the discovery said it had been assumed that using electron beams to study nanostructures carried the additional risk of exacerbating microscopic cracks and flaws already in the material.

Continue reading “Electron Beams Magically Heal Microscopic Fractures, May Also Enable Creation of Objects One Atom at a Time” »

Jailbroken large language models (LLMs) and generative AI chatbots — the kind any hacker can access on the open Web — are capable of providing in-depth, accurate instructions for carrying out large-scale acts of destruction, including bio-weapons attacks.

An alarming new study from RAND, the US nonprofit think tank, offers a canary in the coal mine for how bad actors might weaponize this technology in the (possibly near) future.

In an experiment, experts asked an uncensored LLM to plot out theoretical biological weapons attacks against large populations. The AI algorithm was detailed in its response and more than forthcoming in its advice on how to cause the most damage possible, and acquire relevant chemicals without raising suspicion.

The DNA double helix is composed of two DNA molecules whose sequences are complementary to each other. The stability of the duplex can be fine-tuned in the lab by controlling the amount and location of imperfect complementary sequences.

Fluorescent markers bound to one of the matching DNA strands make the duplex visible, and fluorescence intensity increases with increasing duplex stability. Now, researchers at the University of Vienna succeeded in creating fluorescent duplexes that can generate any of 16 million colors—a work that surpasses the previous 256 colors limitation.

This very large palette can be used to “paint” with DNA and to accurately reproduce any digital image on a miniature 2D surface with 24-bit color depth. This research was published in the Journal of the American Chemical Society.