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Archive for the ‘biotech/medical’ category: Page 923

Apr 22, 2022

Different responses to DNA damage determine ageing differences between organs

Posted by in categories: biotech/medical, life extension

Organs age differently. To investigate the basis of organ-specific ageing we systematically compared at the tissue, stem cell and organoid level two organs representing ageing extremes, from accelera…

Apr 22, 2022

Incredible video shows cancer being killed by immune system cell

Posted by in category: biotech/medical

Microscope footage shows how a fiery T cell latches onto a cancer cell in an attempt to destroy it.

Apr 22, 2022

A new genome reference index could save the gene diversity of humans

Posted by in categories: biotech/medical, genetics

Apr 22, 2022

Largest study of whole genome sequencing data reveals ‘treasure trove’ of clues about causes of cancer

Posted by in categories: biotech/medical, genetics

DNA analysis of thousands of tumors from NHS patients has found a ‘treasure trove’ of clues about the causes of cancer, with genetic mutations providing a personal history of the damage and repair processes each patient has been through.

In the biggest study of its kind, a team of scientists led by Professor Serena Nik-Zainal from Cambridge University Hospitals (CUH) and University of Cambridge, analyzed the complete genetic make-up or whole-genome sequences of more than 12,000 NHS cancer patients.

Because of the vast amount of data provided by , the researchers were able to detect patterns in the DNA of cancer—or ‘mutational signatures’—that provide clues about whether a patient has had a past exposure to environmental causes of cancer such as smoking or UV light, or has internal, cellular malfunctions.

Apr 22, 2022

Lab grown, self-sustainable muscle cells repair injury and disease, mouse study shows

Posted by in categories: biotech/medical, genetics

In proof-of-concept experiments, Johns Hopkins Medicine scientists say they have successfully cultivated human muscle stem cells capable of renewing themselves and repairing muscle tissue damage in mice, potentially advancing efforts to treat muscle injuries and muscle-wasting disorders in people.

A report on the experiments was published April 7 in Cell Stem Cell.

To make the self-renewing stem cells, the scientists began with laboratory-grown human skin cells that were genetically reprogrammed to a more primitive state in which the cells have the potential to become almost any type of cell in the body. At this point, the cells are known as induced pluripotent stem (IPS) cells, and they are mixed with a solution of standard cell growth factors and nutrients that nudge them to differentiate into specific cell types.

Apr 22, 2022

Artificial fingertip gives robots nearly humanlike touch

Posted by in categories: biotech/medical, robotics/AI

3D printed skin reacts to texture and shape like our skin.


The optical properties of mitochondrial bundles in the retina may improve how efficiently the eye captures light.

Apr 22, 2022

BioAge Announces First Cohort Dosed in Clinical Trial for Muscle Aging

Posted by in categories: biotech/medical, life extension

Trial will collect muscle aging biomarker data to inform Phase 2 trials and future development for muscle atrophy in hospitalised patients.

Apr 22, 2022

CRISPR nanocapsule limits growth of aggressive brain tumours in mice

Posted by in categories: biotech/medical, neuroscience

Tiny capsule that delivers CRISPR gene therapy to the brain could be used to target glioblastoma tumours.

Apr 22, 2022

A “magnetic tentacle robot” could hunt down cancer deep in your lungs

Posted by in categories: biotech/medical, robotics/AI

UK researchers have developed a small, flexible, snake-like “magnetic tentacle robot” to navigate deep into the lungs.

Apr 22, 2022

Synthetic DNA Manufacturer has the “Write Stuff”

Posted by in categories: biotech/medical, chemistry, economics, genetics

Circa 2021 Synthetic silicon dna storage.


In research, the demand for DNA strands often outpaces supply. To help supply keep up, researchers may set aside traditional molecular cloning techniques and embrace polymerase chain reaction select PCR)-based techniques. Alternatively, researchers may perform gene synthesis, or the de novo chemical synthesis of DNA. Besides accelerating the creation of genetic sequences, gene synthesis avoids the need for template strands and simplifies procedures such as codon optimization and the fabrication of mutant sequences.

Although gene synthesis can be performed in house, many laboratories prefer to focus on their core competencies and outsource their gene synthesis projects to service providers, especially if sequences of over 1,000 base pairs are desired. Outsourcing also allows laboratories to take advantage of service providers’ economies of scale and quick turnaround times. Finally, service providers offer ease of use. Clients can go online, upload the desired sequences, choose the vector, get the price, and place the order. The entire process takes only a few minutes, and the genes can be delivered a few days later.

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