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Category: biotech/medical – Page 922

Atherosclerosis is a cardiac-based disease where plaque builds up inside the body’s arteries, the blood vessels responsible for carrying oxygen-rich blood to the heart and other organs of the body. Plaque is made up of immune blood cells, known as macrophages, fat, cholesterol, calcium, and other substances found in the blood.

As this plaque hardens it narrows the arteries, limiting the flow of oxygen-rich blood around the body. This, in turn, can lead to serious problems, including heart attack, stroke, or even death.

Now, a study from researchers led by Michigan State University engineers a nanoparticle capable of eating away, from the inside out, heart attack causing plaques. The team states their nanoparticle reduces and stabilizes plaque, providing a potential treatment for atherosclerosis, a leading cause of death in the United States. The study is published in the journal Nature Nanotechnology.

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A new smart skin developed at Stanford University might foretell a day when people type on invisible keyboards, identify objects by touch alone, or allow users to communicate by hand gestures with apps in immersive environments.

In a just-publish paper in the journal Nature Electronics the researchers describe a new type of stretchable biocompatible material that gets sprayed on the back of the , like suntan spray. Integrated in the mesh is a tiny electrical network that senses as the skin stretches and bends and, using AI, the researchers can interpret myriad daily tasks from hand motions and gestures. The researchers say it could have applications and implications in fields as far-ranging as gaming, sports, telemedicine, and robotics.

So far, several promising methods, such as measuring muscle electrical activities using wrist bands or wearable gloves, have been actively explored to enable various hand tasks and gesturing. However, these devices are bulky as multiple sensory components are needed to pinpoint movements at every single joint. Moreover, a large amount of data needs to be collected for each user and task in order to train the algorithm. These challenges make it difficult to adopt such devices as daily-use electronics.

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The findings, published in the Journal of Neuroscience, may help explain how humans form memories and learn, and could eventually aid the development of assistive tools for people affected by neurologic disease or injury. The study was conducted by Massachusetts General Hospital in collaboration with colleagues at Brown University, the Department of Veterans Affairs, and several other institutions.

By MGH news and public affairs.

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Reposting 😗

Thanks to a new experimental gene therapy, one teen’s previously incurable leukemia is now entirely undetectable, marking an incredible breakthrough in genetic immunotherapies. Alyssa, 13, from Leicester in the UK, was told that the only remaining options were end-of-life care to ensure she was comfortable as the aggressive T-cell acute lymphoblastic leukemia took hold – but the experimental CAR-T base editing therapy was able to modify her immune system to clear all detectable cancer cells.

T-cell lymphoblastic leukemia is a type of cancer that affects T-lymphocytes, an immune white blood cell that is created in the bone marrow. In this type of fast-moving leukemia, these cells divide uncontrollably and enter the bloodstream, traveling to the liver, spleen, and lymph nodes. This can cause death in a short span of just months or even weeks without treatment.

Currently, standard care procedures involve chemotherapy and a bone marrow transplant, which is an infamously difficult procedure. In Alyssa’s case, both of these treatments failed.

Continue reading “Experimental Gene Therapy Cures Teen’s “Incurable” Cancer” | >

The body constantly replaces used materials and breaks them down for disposal. MPS VI patients are missing an enzyme essential to breaking down the mucopolysaccharide dermatan sulfate. These materials remain stored in the body’s cells, causing progressive damage. Babies may show little sign of the disease (so better testing is needed), but as cells sustain damage, symptoms start to appear.

Its sad when people have disorders that have a low life expectancy in their 20’s and 30’s EnzymeMaroteaux-Lamy syndrome Is one such affliction, however their is enzyme replacement treatment, but more needs to be done.

Enzyme Replacement Treatment.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752495/

Continue reading “MPS VI” | >

A flipping action in a porous material facilitates the passage of normal water to separate it out from heavy water.

A research group led by Susumu Kitagawa of Kyoto University’s Institute for Cell-Material Sciences (iCeMS), Japan and Cheng Gu of South China University of Technology, China have made a material that can effectively separate heavy water from normal water at room temperature. Until now, this process has been very difficult and energy intensive. The findings have implications for industrial – and even biological – processes that involve using different forms of the same molecule. The scientists reported their results in the journal Nature.

Isotopologues are molecules that have the same chemical formula and whose atoms bond in similar arrangements, but at least one of their atoms has a different number of neutrons than the parent molecule. For example, a water molecule (H2O) is formed of one oxygen and two hydrogen atoms. The nucleus of each of the hydrogen atoms contains one proton and no neutrons. In heavy water (D2O), on the other hand, the deuterium (D) atoms are hydrogen isotopes with nuclei containing one proton and one neutron. Heavy water has applications in nuclear reactors, medical imaging, and in biological investigations.

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A remarkable discovery in a Siberian cave confirmed scientists’ belief that more than 50,000 years ago, interbreeding among the ancient human species might have been common.

A bone fragment discovered by researchers has been analyzed, and the conclusion based on DNA extraction is that it’s a female whose mother was a Neanderthal and father was a Denisovan.

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Following established guidelines about prescription drugs would seem to be an obvious course of action, especially for the professionals that do the prescribing. Yet doctors and their family members are less likely than other people to comply with those guidelines, according to a large-scale study co-authored by an MIT economist.

Depending on your perspective, that result might seem surprising or it might produce a knowing nod. Either way, the result is contrary to past scholarly hypotheses. Many experts have surmised that knowing more, and having easier communication with medical providers, leads patients to follow instructions more closely.

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