Three newly identified indole metabolites from a blood-dwelling bacterium were found to reduce skin cell inflammation and aging markers, offering promise for future anti-aging treatments. People spend a lot of time and money trying to keep their skin looking young, using everything from creams an
Category: biotech/medical – Page 800
A single enzymatic switch steers cell fate in intestinal regeneration
Memorial Sloan Kettering Cancer Center researchers have identified a metabolic switch that determines whether intestinal stem cells become absorptive or secretory cells. Manipulating the enzyme OGDH either fuels cell expansion or redirects fate, with potential consequences for colitis recovery and regenerative therapy.
Stem cells in the intestine maintain a delicate balance between self-renewal and differentiation, continuously replenishing the epithelial lining of the gut.
As they divide, some daughter cells become absorptive enterocytes that expand the surface for nutrient uptake, while others branch into secretory cells that manufacture mucus, antimicrobial peptides, and hormones essential for gut immunity. Injury and inflammation can tip this balance, depleting secretory lineages and disrupting tissue integrity.
Nanogrid drug delivery systems developed for precise lung inflammation treatment
Understanding how drug delivery systems distribute in vivo remains a major challenge in developing nanomedicines. Especially in the lung, the complex and dynamic microenvironment often limits the effectiveness of existing approaches.
“Structural pharmaceutics” has been introduced as a new strategy to connect nanoparticle structures with physiological structures through advanced three-dimensional (3D) imaging and cross-scale characterizations.
In a study published in ACS Nano, a team led by Yin Xianzhen from the Lingang Laboratory and Zhang Jiwen from the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences developed a precise targeting strategy for tracheal inflammation.
New enzymes offer breakthrough in genetic editing beyond CRISPR
A newly discovered family of enzymes can cut single-stranded DNA with exact precision—opening doors to next-gen medical and biotech tools.
New nanoparticle platform breaks through MRSA biofilms
A major cause of hospital-acquired infections, the super bacteria Methicillin-resistant Staphylococcus aureus (MRSA), not only exhibits strong resistance to existing antibiotics but also forms a dense biofilm that blocks the effects of external treatments.
A Downside of Taurine: It Drives Leukemia Growth
Leukemia cells use taurine to produce energy and grow, a study in Nature by a Wilmot Cancer institute team shows.
Scientists visualize key protein structures linked to immune response and inflammation
Two key protein structures in the body are being visualized for the first time, thanks in part to the latest technology in the University of Cincinnati’s Center for Advanced Structural Biology—potentially opening the door for better designed therapeutics.
The research of a trio of UC structural biologists was published today in the Proceedings of the National Academy of Sciences (PNAS).
It’s the first publication to come out of the Seegar Lab at UC. Tom Seegar, Ph.D., Ohio Eminent Scholar and assistant professor in the Department of Molecular and Cellular Biosciences in the College of Medicine, serves as corresponding author of the study.
Common sleep aid blocks brain inflammation and tau buildup in Alzheimer’s model
Scientists have found that lemborexant not only increased restorative sleep in male mice but also reduced levels of toxic tau and brain inflammation. The findings suggest that targeting the brain’s orexin system may help slow Alzheimer’s progression.
Preventing stalling to improve CAR-T cells’ efficacy against tumors
Chimeric antigen receptor (CAR)-T cells are a promising cancer therapy that are made from the patient’s own T cells, which are reprogrammed to fight their cancer. One of the limitations of CAR-T cell therapy is the ability of these cells to survive long enough to target the entire tumor.
Once injected back into the patient, the CAR-T cells tend to rapidly expand when they become activated by the tumor cells, but eventually die off due to a natural process called activation-induced cell death.
In a study published in Science Translational Medicine, a research team discovered a way to alter CAR-T cells so they can partially avoid activation-induced cell death, which allows them to live longer and better fight off the tumor.
Oral-Gut Bacteria Linked to Dementia Risk in Parkinson’s Disease
A new study has found that bacteria from the mouth may migrate to the gut and contribute to cognitive decline in people with Parkinson’s disease.