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Category: biotech/medical – Page 76

Tracking And Trying To Optimize Oxidative Stress Biomarkers

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Blood Testing Essentials (Biological Age, CVD-Risk, Kidney Health and Function):
PhenoAge (Biological Age): https://www.ultalabtests.com/partners…

Measure the Bortz biological clock biomarkers: https://www.ultalabtests.com/partners…

Calculate your biological age using the Bortz clock: https://www.longevity-tools.com/human…

The Next Generation of CRISPR Has Arrived | Dr. Trevor Martin — CEO, Mammoth Biosciences

Dr. Trevor Martin, Ph.D. — Co-Founder & CEO, Mammoth Biosciences

Most of us think of medicine as something we take every day — a statin, a blood pressure pill, or perhaps a monthly injection. But what if those lifelong treatments eventually become obsolete? What if one carefully targeted gene edit could dramatically reduce your risk of heart disease for decades?

Dr. Trevor Martin, Ph.D. is the Co-Founder and Chief Executive Officer of Mammoth Biosciences (https://mammoth.bio/), a pioneering biotechnology company developing next-generation CRISPR genome editing technologies for potentially curative medicines. He co-founded the company in 2017 alongside Nobel Prize-winning CRISPR pioneer Dr. Jennifer Doudna and an interdisciplinary team of leading scientists with the goal of building more precise, versatile, and clinically practical gene editing systems.

Dr. Martin earned his undergraduate degree in Molecular Biology with honors from Princeton University before completing a Ph.D. in Genetics and Statistics at Stanford University, where his research focused on quantitative genetics, genomics, and computational biology. His scientific background in statistics and genetics has shaped Mammoth’s unique approach to developing smaller CRISPR enzymes capable of reaching tissues and diseases that have been difficult to target with first-generation technologies.

Under Dr. Martin’s leadership, Mammoth has grown into one of the world’s leading CRISPR companies, raising more than $465 million, achieving a valuation exceeding $1 billion, and establishing strategic collaborations with companies including Vertex Pharmaceuticals, Bayer, and Regeneron Pharmaceuticals.

Continue reading “The Next Generation of CRISPR Has Arrived | Dr. Trevor Martin — CEO, Mammoth Biosciences” | >

Why the Intelligence Community Is Betting on Biotechnology | Dr. Jessica Dymond, Ph.D. — In-Q-Tel

Dr. Jessica Dymond, Ph.D. — Vice President of Technology, In-Q-Tel.

The same technologies that could transform medicine, agriculture, and manufacturing could also reshape global security. Understanding the future of biotechnology requires scientists who can bridge discovery, engineering, and responsibility.

Today on Progress, Potential, and Possibilities, we’re joined by a true pioneer at the nexus of biotechnology and national security. Dr. Jessica Dymond, Ph.D is the Vice President of Technology at In-Q-Tel (https://www.iqt.org/), a not-for-profit venture fund that invests in companies advancing the strategic priorities of U.S. Intelligence Community, where she provides technical and strategic leadership to accelerate emerging biotechnologies that address some of the most critical challenges to national and global security.

Before In-Q-Tel, Dr. Dymond served as Chief Scientist for Physical and Life Sciences at the Johns Hopkins University Applied Physics Laboratory, where she led an interdisciplinary portfolio spanning biological sensing, genomic surveillance, microbiome engineering, and synthetic biology. She founded the Lab’s Biological Sciences group and spearheaded initiatives to anticipate, assess, and mitigate emerging biological threats while strengthening global health security.

Formally trained as a synthetic biologist, Dr. Dymond earned her Ph.D. from the Johns Hopkins University School of Medicine, completed a postdoctoral fellowship in functional genomics at the U.S. Department of Agriculture, and has contributed to groundbreaking research, including the design of synthetic yeast genomes and combinatorial genomic diversity. She also serves on the editorial board of Synthetic Biology from Oxford University Press.

Continue reading “Why the Intelligence Community Is Betting on Biotechnology | Dr. Jessica Dymond, Ph.D. — In-Q-Tel” | >

Gut bacteria leave intestinal ‘memory,’ protecting against inflammation

New Northwestern Medicine research published in Nature Communications suggests that a metabolite produced by gut bacteria when they digest dietary fiber can leave a lasting molecular imprint on intestinal cells, promoting immune tolerance and protecting against inflammatory bowel disease-like conditions long after exposure ends.

Yingzi Cong, Ph.D., the Stanley Gradowski Professor of Gastroenterology and a professor of Microbiology-Immunology and Pathology, was the senior and co-corresponding author of the study.

Billionaire Home Depot cofounder Bernie Marcus’ foundation donates nearly $30 million toward stem cell research for heart attacks

Marcus’ legacy lives on, and his philanthropic foundation now nods to one of his original passions: medicine.

https://marcusfoundation.org/” href=“https://marcusfoundation.org/”>The Marcus Foundation, established in 1989 by Bernie and his wife, Billi, donated $28.7 million to Dr. Chuck Murry, director of the University of Southern California’s Stem Cell Center, to advance clinical trials of stem cell-based therapies to regenerate damaged tissue after a heart attack.

“Murry and his team have advanced gene-edited cellular therapy to the point that the time is right to support cells as living medicine in this new form of treatment,” Jonathan Simons, chief science officer of The Marcus Foundation, said in a statement.

Humans Could Live for Centuries | Aubrey de Grey

Aubrey de Grey believes ageing is accumulated damage in a biological machine and argues that medicine may eventually become capable of repairing that damage faster than it appears. He gives humanity a 50/50 chance of reaching what he calls “longevity escape velocity” within the next 12–15 years.

Peter and Aubrey discuss why the body ages, the seven categories of damage that must be repaired, stem-cell and gene therapies, the mouse experiment that could transform the field and why Aubrey believes rejuvenation treatment will ultimately be available to everyone rather than reserved for the wealthy.

They also explore what happens to population, work, fertility, relationships, religion and the meaning of life if people stop getting sick from ageing. Aubrey explains why AI cannot replace the missing biological experiments, why longevity research remains so difficult to fund, and why he is driven by the 110,000 people he says die from ageing-related causes every day.

TIMESTAMPS:
00:00:00 — Trailer.
00:00:48 — Can We Cure Ageing?
00:04:24 — The 12–15 Year Prediction.
00:06:17 — The Body Is a Machine.
00:15:21 — How Aubrey Entered Longevity.
00:18:45 — Would You Want to Live Forever?
00:20:15 — Does Longevity Change Risk?
00:21:53 — Will Population Explode?
00:24:22 — Can You Choose Your Age?
00:30:19 — The Seven Types of Ageing Damage.
00:36:54 — What Rejuvenation Treatment Looks Like.
00:45:35 — Will It Be Expensive?
00:48:39 — Who Would Refuse It?
00:53:00 — Why Longevity Research Lacks Funding.
00:56:02 — The Mouse Experiment.
01:00:18 — The Breakthrough That Changes Everything.
01:01:35 — Does Death Give Life Meaning?
01:05:22 — Bryan Johnson and AI
01:12:32 — AlphaFold, AGI and AI Risk.
01:15:13 — Why Funding Is So Hard.

CONTACT PETE:
› Website – https://www.petermccormack.com/
› Feedback – https://www.petermccormack.com/contact.
› Email – [email protected].
› Instagram – / mccormack555
› X/Twitter – https://twitter.com/petermccormack/

CONNECT WITH AUBREY DE GREY:

Continue reading “Humans Could Live for Centuries | Aubrey de Grey” | >

A New Era of Precision Neuromodulation in Psychiatry

Over the past century, advances in neuroimaging and cognitive neuroscience reshaped how we understand psychiatric disorders, expanding the portfolio of evidence-based treatments while routine clinical practice has mostly relied on trial and error. Precision medicine has steadily extended to psychiatry, and today we can target specific cortical or subcortical brain regions within defined pathological circuits to individualize treatments to particular symptoms. Neuromodulation sits at the frontier of this shift in psychiatry, with extensive ongoing research to identify optimal treatment targets and protocols personalized to individuals’ neural circuitry.

Neuromodulation using neuronavigation achieves precise clinical target identification through computer-assisted integration of multimodal brain imaging. Neuron avigated approaches have been central to deep brain stimulation (DBS) for decades. More recent advances in functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) extended this framework from isolated gray matter nuclei toward pathological neural circuits through resting-state functional connectivity analysis and tractography, which enabled the identification of connectomic fingerprints associated with specific symptom clusters, or circuitopathies, a concept particularly relevant to psychiatric disorders, such as obsessive-compulsive disorder and depression.

New findings overturn 100-year-old assumption about common bacteria in the lungs

The human body is teeming with more than 35 trillion bacteria, coexisting in microbiomes inside the gut, mouth, lungs, skin and urogenital tract. While it’s now clear these microbes are associated with health and disease, scientists have only begun to uncover the full scale of their biology and functions.

In a striking example of just how much is still unknown, a new University of Michigan study overturns a 100-year-old assumption about one common bacterial resident of the lungs, Prevotella melaninogenica. The research is published in the Journal of Bacteriology.

The lab led by Ariangela Kozik, Ph.D., assistant professor of internal medicine at U-M Medical School and assistant professor of molecular, cellular and developmental biology at U-M, is interested in Prevotella because the bacteria are commonly found in the respiratory tract and reportedly associated with all manner of chronic conditions, yet are also found in healthy people. The genus is also widely thought to be an obligate anaerobe, incapable of surviving in the presence of oxygen.

Deep brain stimulation strengthens reward signals after one 20-minute session, study finds

A study from Emory University School of Medicine suggests that a single 20-minute session of noninvasive deep brain stimulation, paired with mindful breathing, may strengthen the brain’s response to reward and reduce anxiety. Changes in reward-related brain activity remained detectable for approximately one week after the session.