Infection is a constant risk. Any germs that make it past the body’s barriers, like the skin, can cause illness if the immune system does not respond properly and efficiently. Most people can easily fight off common bacteria that could be pathogenic, but people with weaker or compromised immune systems have a greater risk of infection. For the immunocompromised, bacteria like Pseudomonas aeruginosa that are everywhere in the environment can start to grow in different parts of the body, including the lungs; if this occurs, a chronic and even lifelong infection can arise. If bacteria that cause these chronic infections move to the bloodstream, they can become far more serious and even deadly. Scientists are still learning about how bacteria are able to make the transition.
New work has provided insight into how P. aeruginosa can change from causing one type of infection to another. This study used human samples to reveal a biomarker that indicates when this transition has taken place, in the form of a small RNA generated by the bacterium. The findings have been reported in Nature.
