Recent research highlights the dual role of VEGF-C-producing macrophages in breast tumors, potentially guiding metastasis to less harmful areas, opening new avenues for targeted cancer therapies.
A new study from Karolinska Institutet published in Cell reports shows that tumor-associated macrophages, which are white blood cells that are found in breast tumors, can both help and hinder the spread of cancer cells to other organs. The researchers found that macrophages that produce a substance called VEGF-C reduce the spread of breast cancer to the lungs but increase the spread to the lymph nodes. This may have implications for the prognosis and treatment of breast cancer.
Understanding breast cancer and the role of tams.
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