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Researchers find immune pathway in joint tissue involved in early rheumatoid arthritis

A new study by scientists at the University of Colorado Anschutz Medical Campus reveals that joint tissue from patients with early-stage rheumatoid arthritis often have high levels of a protein called granzyme used by the immune system to attack pathogens.

The study also detected remnants of a bacteria that causes —gingivitis—in the . While a connection between gingivitis and rheumatoid arthritis has long been suspected, this is the first time physical evidence of the bacteria in the has been detected.

Researchers said the findings strongly support the hypothesis that these bacteria, initially colonizing gum tissue, somehow drive the development of rheumatoid arthritis, at least in some patients. How the bacteria get into the joints remains unknown. These findings, they said, could lead to earlier diagnosis and treatment of this chronic disease.

AI predicts patients likely to die of sudden cardiac arrest

A new AI model is much better than doctors at identifying patients likely to experience cardiac arrest. The linchpin is the system’s ability to analyze long-underused heart imaging, alongside a full spectrum of medical records, to reveal previously hidden information about a patient’s heart health.

The work, led by Johns Hopkins University researchers, could save many lives and also spare many people unnecessary medical interventions, including the implantation of unneeded defibrillators.

“Currently, we have patients dying in the prime of their lives because they aren’t protected and others who are putting up with defibrillators for the rest of their lives with no benefit,” said senior author Natalia Trayanova, a researcher focused on using artificial intelligence in cardiology. “We have the ability to predict with very high accuracy whether a patient is at very high risk for or not.”

People who adopted pets during the pandemic often struggled to access vet care, study finds

During the COVID-19 pandemic when many were stuck at home, people adopted more pets than average, but then struggled to find adequate veterinary care. Kayla Pasteur of Purdue University, U.S., and colleagues reported these findings and other pandemic pet trends, which were published in a study in the open-access journal PLOS One.

In the U.S., about 58 million U.S. households keep one or more dogs and 40 million keep at least one cat. These animals often provide a source of enjoyment, and in the home, so it’s no surprise that during the COVID-19 pandemic, there was an increase in pet purchases and adoptions.

In the new study, researchers investigated trends in during the pandemic to understand which groups were acquiring pets and how the pandemic impacted their ability to access veterinary care. The team analyzed answers to an of 751 U.S. residents – of which 79% were pet owners – conducted in late 2021.

Unique method enables simulation of error-correctable quantum computers

Quantum computers still face a major hurdle on their pathway to practical use cases: their limited ability to correct the arising computational errors. To develop truly reliable quantum computers, researchers must be able to simulate quantum computations using conventional computers to verify their correctness—a vital yet extraordinarily difficult task.

Now, in a world-first, researchers from Chalmers University of Technology in Sweden, the University of Milan, the University of Granada, and the University of Tokyo have unveiled a method for simulating specific types of error-corrected quantum computations—a significant leap forward in the quest for robust quantum technologies.

Quantum computers have the potential to solve complex problems that no supercomputer today can handle. In the foreseeable future, ’s computing power is expected to revolutionize fundamental ways of solving problems in medicine, energy, encryption, AI, and logistics.

Researchers take major step toward cuff-free blood pressure monitoring

Researchers have shown, for the first time, that speckle contrast optical spectroscopy (SCOS) can be used for cuffless blood pressure monitoring. The new technology could improve early detection and management of hypertension.

“Hypertension affects nearly half of all adults in the US and is the leading cause of cardiovascular disease,” said Ariane Garrett, a doctoral student in Darren Roblyer’s lab at Boston University. “This research is a step toward a that would let people monitor their any time, without a cuff.”

SCOS is a noninvasive imaging technique that measures by analyzing speckle patterns formed by coherent light scattering from cells and tissue. While it has been used for other applications such as brain and tissue monitoring, this is one of the first studies to explore how SCOS signals relate to blood pressure.

Open House

Have you heard about the crazy guys who bought an entire tower to convert it into a vertical village? Yes, that’s us.

Do you want to walk the 16-floor tower and explore the space? Still on the fence, if you should become a citizen? Do you have questions about how you can get involved and co-create? Wanna hear updates on what happened in the last 2 weeks? This event is for you! 👩‍🚀

About us: We are transforming a 16-floor tower in the heart of San Francisco into a self-governed vertical village —a hub for frontier technologies and creative arts. 8 themed floors will be dedicated to creating tier-one labs, spanning AI, Ethereum, biotech, neuroscience, longevity, robotics, human flourishing, and arts & music. These floors will house innovators and creators pushing the boundaries of human potential in a post-AI-singularity world.

DNA as a perfect quantum computer based on the quantum physics principles

I believe that dna will be able to answer just about all our genetic coding questions so much that it will lead to even better breakthroughs in the future and use hardly any energy. I believe also that the master algorithm can eventually be derived from DNA as dna seems already a perfect master algorithm for human beings where human beings are the key to all future progress. I say this as quantum computing is still not stable but we already know that dna computers seem already a masterpiece already especially even organoids of the human brain. Really it becomes really quite simple as even the quantum realm is unstable but dna computers that are quantum would stabilize this currently unstable realm.


Riera Aroche, R., Ortiz García, Y.M., Martínez Arellano, M.A. et al. DNA as a perfect quantum computer based on the quantum physics principles. Sci Rep 14, 11,636 (2024). https://doi.org/10.1038/s41598-024-62539-5

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Disease-Modifying, Neuroprotective Effect of N-Acetyl-l-Leucine in Adult and Pediatric Patients With Niemann-Pick Disease Type C

Background and ObjectivesN-acetyl-l-leucine (NALL) has been established to improve the neurologic manifestations of Niemann-Pick disease type C (NPC) after 12 weeks in a placebo-controlled trial. In the open-label extension phase (EP) follow-up, data were…

Outcomes in Transplant Recipients With Advanced Cancers Receiving Immune Checkpoint Inhibitors

This systematic review and individual participant data met-analysis assesses the cancer-related and survival outcomes in solid organ transplant recipients with advanced-stage cancer treated with immune checkpoint inhibitors.

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