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Category: biotech/medical – Page 726

Washington [US], March 5 (ANI): A team of researchers from Michigan State University’s College of Veterinary Medicine made a discovery that may have significance for therapeutic gene editing strategies, cancer diagnostics and therapies and other advancements in biotechnology. Kathy Meek, a professor in the College of Veterinary Medicine, and collaborators at Cambridge University and the National Institutes of Health have uncovered a previously unknown aspect of how DNA double-stranded breaks are repaired.

A large protein kinase called DNA-PK starts the DNA repair process; in their new report, two distinct DNA-PK protein complexes are characterized, each of which has a specific role in DNA repair that cannot be assumed by the other.

“It still gives me chills,” says Meek. “I don’t think anyone would have predicted this.”

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The study, led by Jimo Borjigin, associate professor of molecular and integrative physiology and neurology at Michigan, was very small, featuring only four patients. But the findings echo animal model studies, where the presence of gamma waves in dying brains has also been observed, including in a previous study in rats that Borjigin and colleagues ran a decade earlier.

“These data demonstrate that the surge of gamma power and connectivity observed in animal models of cardiac arrest can be observed in select patients during the process of dying,” the researchers wrote in their paper, published in PNAS.

What are gamma waves? Gamma waves are high-frequency brain waves researchers believe represent multiple areas of the brain working together in complex thoughts. Take, for example, combining the sight, sound, and smell of a car to get a full picture of the vehicle, Ajmal Zemmar, a neurosurgeon at the University of Louisville uninvolved with the study, told Science.

Researchers have also found patterns of gamma waves in healthy people while dreaming, learning, and recalling lessons, Science reported, with some researchers associating them with consciousness itself. But the exact mechanisms behind gamma waves are “one of the biggest mysteries in neuroscience,” Zemmar said.

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Summary: A new speech prosthetic offers hope for those with speech-impairing neurological disorders.

By converting brain signals into speech using high-density sensors and machine learning, the technology represents a significant advancement over current slower communication aids.

Though still in early stages, the device has achieved a 40% accuracy in decoding spoken data during limited trials and is moving towards a cordless design.

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Summary: Researchers challenge a 75-year-old neuroscience hypothesis, suggesting dendrites play a crucial role in brain computation, not just the neuronal soma.

Experiments conducted under non-physiological conditions revealed that neuron features like firing frequency and stimulation threshold are controlled by dendrites.

This groundbreaking discovery implies that dendrites could be pivotal in learning processes and may even influence our understanding of brain states and degenerative diseases.

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Equivalent to an 80-year-old human reverting to the age of 26.

A groundbreaking study into anti-aging has reported significant rejuvenation effects using exosomes, tiny particles which can be extracted from biological fluids such as blood plasma.

Old and young rat. Image generated by DALL·E 3

In recent years, the prospect of being able to halt or even reverse aging has begun to seem less like science fiction and more like a scientific milestone that could emerge in the relatively near future.

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This research is still in the initial stages and needs further investigation before it becomes part of the pacemakers used today.

Researchers at the University of Washington (UW) in Seattle successfully designed a leadless pacemaker that can be partially charged using energy generated by the beating heart. The research findings will be presented at the American Heart Association’s (AHA) Scientific Sessions to be held later this weekend, a press release said.

Pacemakers are small devices that detect a patient’s heartbeat and send electrical pulses to the heart if it needs to be paced. According to the AHA’s report, as many as 93,000 pacemaker and defibrillator procedures were performed in the US in 2018.

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The COVID-19 pandemic has focused attention on patterns of infectious disease spillover. Climate and land-use changes are predicted to increase the frequency of zoonotic spillover events, which have been the cause of most modern epidemics. Characterising historical trends in zoonotic spillover can provide insights into the expected frequency and severity of future epidemics, but historical epidemiological data remains largely fragmented and difficult to analyse. We utilised our extensive epidemiological database to analyse a specific subset of high-consequence zoonotic spillover events for trends in the annual frequency and severity of outbreaks. Our analysis, which excludes the ongoing SARS-CoV-2 pandemic, shows that the number of spillover events and reported deaths have been increasing by 4.98% (confidence interval [CI]95% [3.22%; 6.76%]) and 8.7% (CI 95% [4.06%; 13.62%]) annually, respectively. This trend can be altered by concerted global efforts to improve our capacity to prevent and contain outbreaks. Such efforts are needed to address this large and growing risk to global health.

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Harnessing and controlling light plays a pivotal role in technological advancement, impacting energy harvesting, computation, communications, and biomedical sensing. Nevertheless, in real-world scenarios, the intricate behavior of light presents challenges for efficient control.

Physicist Andrea Alù draws a parallel between the behavior of light in chaotic systems and a game of billiards, where slight variations in the cue ball’s launch result in different ball trajectories on the table.

“In billiards, tiny variations in the way you launch the cue ball will lead to different patterns of the balls bouncing around the table,” said Alù, Einstein Professor of Physics at the CUNY Graduate Center, founding director of the Photonics Initiative at the CUNY Advanced Science Research Center and distinguished professor at CUNY. “Light rays operate in a similar way in a chaotic cavity. It becomes difficult to model to predict what will happen because you could run an experiment many times with similar settings, and you’ll get a different response every time.”

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