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Category: biotech/medical – Page 72

Scale of how chronic fatigue syndrome affects patients’ blood shown for first time

People with ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome) have significant differences in their blood compared with healthy individuals, a new study reveals, suggesting a path toward more reliable diagnosis of the long-term debilitating illness. The paper is published in the journal EMBO Molecular Medicine.

The largest ever biological study of ME/CFS has identified consistent blood differences associated with chronic inflammation, insulin resistance, and liver disease.

Significantly, the results were mostly unaffected by patients’ activity levels, as low activity levels can sometimes hide the biological signs of illness, experts say.

Magically reducing errors in quantum computers: Researchers invent technique to decrease overhead

For decades, quantum computers that perform calculations millions of times faster than conventional computers have remained a tantalizing yet distant goal. However, a new breakthrough in quantum physics may have just sped up the timeline.

In an article titled “Efficient Magic State Distillation by Zero-Level Distillation” published in PRX Quantum, researchers from the Graduate School of Engineering Science and the Center for Quantum Information and Quantum Biology at the University of Osaka devised a method that can be used to prepare high-fidelity “magic states” for use in quantum computers with dramatically less overhead and unprecedented accuracy.

Quantum computers harness the fantastic properties of quantum mechanics such as entanglement and superposition to perform calculations much more efficiently than classical computers can. Such machines could catalyze innovations in fields as diverse as engineering, finance, and biotechnology. But before this can happen, there is a significant obstacle that must be overcome.

Intercellular fluid flow, not just cell structure, governs how tissues respond to physical forces

Water makes up around 60% of the human body. More than half of this water sloshes around inside the cells that make up organs and tissues. Much of the remaining water flows in the nooks and crannies between cells, much like seawater between grains of sand.

Now, MIT engineers have found that this “intercellular” fluid plays a major role in how tissues respond when squeezed, pressed, or physically deformed. Their findings could help scientists understand how , tissues, and organs physically adapt to conditions such as aging, cancer, diabetes, and certain neuromuscular diseases.

In a paper appearing in Nature Physics, the researchers show that when a is pressed or squeezed, it is more compliant and relaxes more quickly when the fluid between its cells flows easily. When the cells are packed together and there is less room for intercellular flow, the tissue as a whole is stiffer and resists being pressed or squeezed.

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Cells assembled into Anthrobots become biologically younger than the original cells they were made from

Modern humans have existed for more than 200,000 years, and each new generation has begun with a single cell—dividing, changing shape and function, organizing into tissues, organs, and limbs. With slight variations, the process has repeated billions of times with remarkable fidelity to the same body plan.

Researchers at Tufts have been on a quest to understand the code guiding individual cells to create the architecture of a human being, and to create a foundation for . As they learn more about that code, they are also looking at how to build living structures from human cells that have totally new forms and capabilities—without genetic manipulation.

To decipher that code, they took a cell from the human body and allowed it to grow in a novel environment to observe how the rules of self-organization play out.

FDA-Approved Sleeping Pill Slows Alzheimer’s Tangles in Pre-Clinical Trial

A drug used to treat insomnia has protected mice against the buildup of the tau protein found to clump abnormally in neurodegenerative diseases like Alzheimer’s. This could lead to new ways to help slow the progress of these diseases.

An increasing number of people are facing cognitive decline personally or in their loved ones. There are almost 10 million new cases of dementia globally each year, and despite decades of research, there are still few treatment options that provide clear benefits.

So due to the links between Alzheimer’s and poor sleep, Washington University neurologist Samira Parhizkar and colleagues investigated a central nervous system depressant, lemborexant, that was approved for use as a sleep aid by the FDA in December 2019.

Breakthrough: FDA Approves Injection to Prevent HIV

The US Food and Drug Administration on Wednesday approved Gilead Sciences’ twice-yearly injection to prevent HIV – a move the company hailed as a major breakthrough in the fight against the sexually transmitted virus.

Drugs to prevent HIV transmission, known as pre-exposure prophylaxis or PrEP, have existed for more than a decade. But because they typically require taking a daily pill, they have yet to make a significant dent in global infections.

“This is a historic day in the decades-long fight against HIV,” Gilead chairman and chief executive Daniel O’Day said in a statement.

Startup’s biosensor makes drug development and manufacturing cheaper

In the biotech and pharmaceutical industries, ELISA tests provide critical quality control during drug development and manufacturing. The tests can precisely quantify protein levels, but they also require hours of work by trained technicians and specialized equipment. That makes them prohibitively expensive, driving up the costs of drugs and putting research testing out of reach for many.

Now the Advanced Silicon Group (ASG), founded by Marcie Black ’94, MEng ’95, PhD ’03 and Bill Rever, is commercializing a new technology that could dramatically lower the time and costs associated with protein sensing. ASG’s proprietary sensor combines silicon nanowires with antibodies that can bind to different proteins to create a highly sensitive measurement of their concentration in a given solution.

The tests can measure the concentration of many different proteins and other molecules at once, with results typically available in less than 15 minutes. Users simply place a tiny amount of solution on the sensor, rinse the sensor, and then insert it into ASG’s handheld testing system.

“We’re making it 15 times faster and 15 times lower cost to test for proteins,” Black says. “That’s on the drug development side. This could also make the manufacturing of drugs significantly faster and more cost-effective. It could revolutionize how we create drugs in this country and around the world.”

Advanced Silicon Group, founded by MIT alumna Marcie Black, developed a protein sensor that could make drug development and manufacturing much faster and less expensive.

Stir stick that detects spiked drinks developed by UBC researchers

Researchers at the University of British Columbia say they have developed a new tool to detect common drink-spiking drugs.

They say they plan to test the device, known as Spikeless, in the hopes it will one day be used widely to combat drugs being added to drinks and to prevent sexual assaults.

The university said in a news release that the “seemingly ordinary stir stick” can detect drugs such as GHB and ketamine within 30 seconds, changing colour if a beverage is contaminated.

Sasha Santos, an anti-violence activist working with the researchers on the project, says the technology has the potential to be a game-changer, adding that other drug testing tools are marketed to customers in a problematic way.

An anti-violence activist says the invention, which can detect drugs within 30 seconds, aims to make the stir sticks ubiquitous in bars, clubs and pubs, so every single drink served comes with a safety test.