Lifeboat Foundation

The first protein-based nano-computing agent that functions as a circuit has been created by Penn State researchers. The milestone puts them one step closer to developing next-generation cell-based therapies to treat diseases like diabetes and cancer.

Traditional synthetic biology approaches for cell-based therapies, such as ones that destroy cancer cells or encourage tissue regeneration after injury, rely on the expression or suppression of proteins that produce a desired action within a cell. This approach can take time (for proteins to be expressed and degrade) and cost cellular energy in the process. A team of Penn State College of Medicine and Huck Institutes of the Life Sciences researchers are taking a different approach.

“We’re engineering proteins that directly produce a desired action,” said Nikolay Dokholyan, G. Thomas Passananti Professor and vice chair for research in the Department of Pharmacology. “Our protein-based devices or nano-computing agents respond directly to stimuli (inputs) and then produce a desired action (outputs).”

While hearing aids and cochlear implants offer limited relief, no available treatment can reverse or prevent this group of genetic conditions, prompting scientists to evaluate gene therapies for alternative solutions.

One of the most promising tools used in these therapies—adeno associated virus (AAV) vectors—has galvanized the hearing-loss community in recent years.

A recent study published in the journal Scientific Reports assessed the associations between the change in total cholesterol (TC) levels after type 2 diabetes (T2D) diagnosis (relative to pre-diagnosis levels) and the risk of cardiovascular disease (CVD).

CVD is the global leading cause of mortality. T2D is a gateway disease to CVD. A study revealed higher coronary heart disease (CHD) and stroke risks in diabetes patients than in non-diabetic individuals. The global prevalence of T2D is expected to exceed 10% by 2030. Therefore, preventing CVD in people with diabetes could be of public health significance.

Hypercholesterolemia is a significant risk factor for CVD, and its adverse effects on CVD could be more evident in individuals with metabolic conditions, e.g., T2D. Diabetes patients may be more susceptible to hypercholesterolemia’s negative impact on CVD risk. Nonetheless, T2D diagnosis often results in positive lifestyle changes helping reduce hypercholesterolemia or CVD risk.

A new study published on eLife and led by the Institute for Evolutionary Biology (IBE, CSIC-UPF) and the IRB Barcelona, has revealed that the Chinmo gene is responsible for establishing the juvenile stage in insects. It also confirms that the Br-C and E93 genes play a regulatory role in insect maturity. These genes, which are also present in humans, act as a promoter and as a suppressor, respectively, of cancerous processes.

The results of the research, which was carried out with the fruit fly Drosophila melanogaster and the cockroach Blatella germanica, reveal that these genes have been conserved throughout the evolution of insects. Therefore, it is believed that they could play a key role in the evolution of metamorphosis.

Insects that undergo complete metamorphosis, such as flies, go through the following three stages of development: the embryo, which is formed inside the egg; the larva (juvenile stage), which grows in several phases; and the pupa, which is the stage that encompasses metamorphosis and the formation of the adult organism.

Australian researchers have used the “wonder material” graphene to develop a sensor that could enable anyone to control robot technology with their minds.

“The hands-free, voice-free technology works outside laboratory settings, anytime, anywhere,” said co-developer Francesca Iacopi. “It makes interfaces such as consoles, keyboards, touchscreens, and hand-gesture recognition redundant.”

Continue reading “Graphene sensor could let you control robots with your mind” »

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Neuralink, Elon Musk’s brain-implant company, said on Thursday it had received a green light from the US Food and Drug Administration (FDA) to kickstart its first in-human clinical study, a critical milestone after earlier struggles to gain approval.

Musk has predicted on at least four occasions since 2019 that his medical device company would begin human trials for a brain implant to treat severe conditions such as paralysis and blindness.

Continue reading “Elon Musk’s brain implant company Neuralink approved for in-human study” »

Implanted brain electrodes send signals that bypass damaged spinal cord area, using man’s thoughts to stimulate leg movement.

So it is confirmed that the new variant of covid 19 virus is here but the actual spike now is in China. But will most likely spread globally much how previous viruses have done. Be sure to be prepared for another pandemic. Anyway what may be the possible cure would be new bioengineering techniques with crispr to eventually be immune to the virus like I have posted in some genetically engineered cells recently were made. But rest assured this could lead to a global pandemic because the current variant is taxing our current vaccination measures.

The country once had some of the harshest Covid restrictions on the planet, but the response from the government and the public is relatively muted this time.

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Scientists in Finland have developed a nanodevice that can measure the absolute power of microwave radiation down to the femtowatt level at ultra-low temperatures—a scale trillion times lower than routinely used in verifiable power measurements. The device has the potential to significantly advance microwave measurements in quantum technology.

Quantum science takes place mostly at ultra-low temperatures using devices called dilution refrigerators. The experiments also have to be done at tiny energy levels—down to the energy level of single photons or even less. Researchers have to measure these extremely low energy levels as accurately as possible, which means also accounting for heat—a persistent problem for quantum devices.

Continue reading “Quantum scientists accurately measure power levels 1 trillion times lower than usual” »