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Category: biotech/medical – Page 345

Muscle tissue meets mechanics in biohybrid hand breakthrough

Combining lab-grown muscle tissue with a series of flexible mechanical joints has led to the development of an artificial hand that can grip and make gestures. The breakthrough shows the way forward for a new kind of robotics with a range of potential applications.

While we’ve seen plenty of soft robots at New Atlas and a truly inspiring range of mechanical prosthetics, we’ve yet to see too many inventions that quite literally combine human tissue with machines. That’s likely because the world of biohybrid science is still in its very early stages. Sure, there was an artificial fish powered by human heart cells and a robot that used a locust’s ear to hear, but in terms of the practical use of the technology, the field has remained somewhat empty.

Now though, researchers at the University of Tokyo and Waseda University in Japan have shown a breakthrough demonstrating the real promise of the technology.

Light-activated Ink Developed to Remotely Control Cardiac Tissue to Repair the Heart

Researchers from Mass General Brigham and collaborating institutions have developed a non-invasive approach to manipulate cardiac tissue activity by using light to stimulate an innovative ink incorporated into bioprinted tissue. Their goal is to develop a technique that can be used to repair the heart. Their findings in preclinical models, published in Science Advances, show the transformative potential of non-invasive therapeutic methods to control electrically active tissues.

“We showed for the first time that with this optoelectronically active ink, we can print scaffolds that allow remote control of engineered heart tissues,” said co-corresponding author Y. Shrike Zhang, Ph.D., of the Division of Engineering in Medicine at Brigham and Women’s Hospital, a founding member of the Mass General Brigham health care system. “This approach paves the way for non-invasive light stimulation, tissue regeneration, and host integration capabilities in cardiac therapy and beyond.”

Three-dimensional bioprinted tissues composed of cells and other body-compatible materials are a powerful emerging tool to repair damaged heart tissue. But most bioprinted tissues cannot generate the necessary electrical activity for cellular function. They must instead rely on invasive wire and electrode placement to control heart activity, which can damage body tissues.

Deep learning provides new view on 300 million years of brain evolution

In a new study published in Science, a Belgian research team explores how genetic switches controlling gene activity define brain cell types across species. They trained deep learning models on human, mouse, and chicken brain data and found that while some cell types are highly conserved between birds and mammals after millions of years of evolution, others have evolved differently.

The findings not only shed new light on evolution; they also provide powerful tools for studying how shapes different cell types, across species or different disease states.

Our brain, and by extension our entire body, is made up of many different types of cells. While they share the same DNA, all these cell types have their own shape and function. What makes each cell type different is a complex puzzle that researchers have been trying to put together for decades from short DNA sequences that act like switches, controlling which genes are turned on or off.

Nanoparticles successfully deliver genetic material to plants via roots

University of Queensland researchers have for the first time introduced genetic material into plants via their roots, opening a potential pathway for rapid crop improvement. The research is published in Nature Plants.

Professor Bernard Carroll from UQ’s School of Chemistry and Molecular Biosciences said nanoparticle technology could help fine-tune plant genes to increase crop yield and improve food quality.

“Traditional plant breeding and take many generations to produce a new crop variety, which is time-consuming and expensive,” Professor Carroll said.

Active matter: Scientists create three-dimensional ‘synthetic worms’

Researchers at the University of Bristol have made a breakthrough in the development of “life-like” synthetic materials which are able to move by themselves like worms.

Scientists have been investigating a new class of materials called “active matter,” which could be used for various applications from to .

Compared to inanimate matter—the sort of motionless materials we come across in our lives every day, such as plastic and wood—active matter can show fascinating life-like behavior.

Generating record-speed waves on extremely water-repellent surfaces

Ripples, like ones produced by raindrops falling in a puddle, are also called capillary waves. Studied since antiquity, they have garnered considerable interest in modern science due to their ability to reveal information about the medium on which they travel. This makes them particularly valuable for studying soft and biological matter in microfluidic applications, which focus on how fluids behave in microscopic environments.

Now physicists and from Aalto University’s Department of Neuroscience and Biomedical Engineering and Department of Applied Physics have unearthed new characteristics of capillary waves, setting a record for their speed while doing so.

The paper is published in Nature Communications.

Lost for Words? Scientists Decode the Brain’s Hidden Speech Signals

The first step in this process is determining where in the brain the BCI should record from to decode someone’s intended speech.

Currently, BCI devices are only used on individuals with paralysis from ALS or stroke in the brainstem, which leaves them unable to move or communicate. In these patients, BCIs record signals from the frontal lobe. But Broca’s aphasia, which most often affects people after a stroke or brain tumor, results from damage to the frontal lobe of the brain, where speech production and parts of language are processed. So, to help patients with Broca’s aphasia, scientists would likely need to record signals from other areas of the brain.

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