Haynes et al. report a daily, sleep-dependent neuron–glia lipid metabolic cycle. ApoE-dependent lipid transfer from neurons to glia protects neurons from oxidative damage during waking, and lipids are cleared from glia during sleep.
Category: biotech/medical – Page 324
Physiologic Pacing in Heart Failure
Cardiac physiologic pacing, also known as cardiac resynchronization therapy, is indicated in patients with heart failure, reduced left ventricular ejection fraction (LVEF) of 50% or less, and either a high (or anticipated high) ventricular pacing burden or a wide QRS complex. Traditionally, physiologic pacing has been achieved with biventricular pacing with a right ventricular lead and a coronary sinus branch lead. Randomized trials involving more than 10,000 patients with heart failure have shown clinical, exercise, and quality-of-life benefits associated with biventricular pacing, as well as improved LVEF and reduced mitral regurgitation and ventricular volumes. These benefits are greatest in patients with left bundle-branch block and a QRS duration of 150 msec or longer.
Utility of Stereoelectroencephalography in the Treatment of Drug-Resistant Epilepsy
About one-third of people with epilepsy have drug-resistant disease—but surgery can be transformative. Drs Ihnen & Arya at Cincinnati Children’s explore how SEEG is reshaping presurgical evaluation in DRE. https://ow.ly/M15c50Y0Y0W
Epilepsy society american epilepsy society epilepsy foundation of america.
DRE can be effectively treated with epilepsy surgery, leading to seizure freedom in appropriately selected individuals.
New twist on BRCA1-mediated DNA recombination repair and tumor suppression
BRCA1-mediated DNA recombination repair and tumor suppression.
BRCA1 is dispensable for end resection at replication-coupled double-strand breaks (DSBs) but stimulates processing of replication-independent DSBs.
BRCA1 promotes RAD51 assembly downstream of end resection.
Canonical BRCA1/RAD51-dependent homologous recombination is essential for tumor suppression.
Loss of 53BP1 enables alternative BRCA1-independent RAD51 assembly.
Alternative BRCA1-independent RAD51 assembly supports tissue development but is not sufficient for tumor suppression. sciencenewshighlights ScienceMission https://sciencemission.com/BRCA1-mediated-DNA-recombination-repair
Bionic LiDAR system achieves beyond-retinal resolution through adaptive focusing
In a recent study, researchers from China have developed a chip-scale LiDAR system that mimics the human eye’s foveation by dynamically concentrating high-resolution sensing on regions of interest (ROIs) while maintaining broad awareness across the full field of view.
The study is published in the journal Nature Communications.
LiDAR systems power machine vision in self-driving cars, drones, and robots by firing laser beams to map 3D scenes with millimeter precision. The eye packs its densest sensors in the fovea (sharp central vision spot) and shifts gaze to what’s important. By contrast, most LiDARs use rigid parallel beams or scans that spread uniform (often coarse) resolution everywhere. Boosting detail means adding more channels uniformly, which explodes costs, power, and complexity.
Nature-inspired ‘POMbranes’ could transform water recycling in textile and pharma industries
Scientists have collaborated to develop a new class of highly precise filtration membranes. The research, published in the Journal of the American Chemical Society, could significantly reduce energy consumption and enable large-scale water reuse in industry. The team includes researchers from the CSIR-Central Salt and Marine Chemicals Research Institute (CSMCRI), Indian Institute of Technology Gandhinagar, the Nanyang Technological University, Singapore, and the S N Bose National Centre for Basic Sciences.
Everyday industrial processes, like purifying medicines, cleaning textile dyes, and processing food, rely on “separations.” Currently, these processes are incredibly energy-hungry, accounting for nearly 40% to 50% of all global industrial energy use. Most factories still use old-fashioned methods like distillation and evaporation to separate ingredients, which are expensive and leave a heavy carbon footprint.
Although membrane-based technologies are considered cleaner, most polymer membranes currently used in industry have irregularly sized pores that tend to degrade over time, limiting their effectiveness. Thus, they lack the precision and long-term stability needed for demanding industrial applications.
