Toggle light / dark theme

A team of Massachusetts General Hospital (MGH) investigators has made the first steps towards development of bioartificial replacement limbs suitable for transplantation They had used decellularization technique to regenerate kidneys, livers, hearts and lungs from animal models, but this is the first reported use to engineer the more complex tissues of a bioartificial limb.

They took the leg from recently deceased rat and then:

* Over a period of 52 hours, infusion of a detergent solution removes cells from a rat forelimb, leaving behind the cell-free matrix scaffolding onto which new tissues can be regenerated.

* it is put in a specially designed bioreactor and after 2 weeks it is recellularized

* they graft some skin onto the fledgling leg, and the doctors had themselves their own, home-grown rat limb (minus the bones and cartilage).

* they attached it to a rat

What if instead of taking the leg of dead rat you took the leg of an old rat and recellularized it with its own stem cells.

http://www.popsci.com/sites/popsci.com/files/styles/medium_1x_/public/psc0615_cs_010.jpg?itok=TU2MmPPC

On a snowy evening in Brooklyn, New York, sweat is streaming from my pores, rolling down my face, back, and palms. I don’t know what the temperature is here inside the MRI machine, but “summer in the Sahara” seems about right. I keep thinking about how I should have shed my winter-weight pants and button-down shirt.

The lab technician chimes in over a microphone. He reminds me not to move or I’ll need to start the MRI over. Considering I’ve been here for 45 minutes, that doesn’t sound appealing. My eyes sting, and sweat has pooled in weird places. I imagine this is what Chinese water torture feels like. Add to that, I have a gadolinium contrast agent coursing through my body. The substance is supposed to highlight areas of inflammation, but it can also make you feel like you’re itching from within. Read more