Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 2,922

Very cool.

Pinpointing the type of bacteria that are at the root of an infection in clinical samples removed from living tissues, such as blood, urine or joint fluids, to quickly identify the best anti-microbial therapy still poses a formidable challenge. The standard method of culturing can take days to reveal pathogens, and they often fail to bring them to light altogether.

A team lead by Donald Ingber, M.D., Ph.D., at the Wyss Institute for Biologically Inspired Engineering at Harvard University now reports a method in PLoS, which enables the rapid isolation and concentration of infectious bacteria from complex clinical samples to help speed up bacterial identification, and it should be able to accelerate the determination of antibiotic susceptibilities as well.

“We leveraged FcMBL? the genetically engineered pathogen-binding protein we developed for our sepsis therapeutic device program? to develop a fast and simple technology to help overcome this diagnostic roadblock,” said Ingber, who is the Wyss Institute’s Founding Director, the Judah Folkman Professor of Vascular Biology at Harvard Medical School and the Vascular Biology Program at Boston Children’s Hospital, and Professor of Bioengineering at the Harvard John A. Paulson School of Engineering and Applied Sciences. “Using clinical samples of joint fluids, we were able to show that this method can be used to quickly and efficiently isolate bacterial pathogens for various kinds of subsequent analysis, including PCR, which is commonly used for molecular diagnostics in clinical laboratories.”

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Machines running on human energy? Yes, it can happen, according to Dan Nicolau, Jr. from the Department of Integrative Biology at the University of California. Nicolau and his colleagues successfully completed a proof-of-concept study of a book-sized computer that runs on adenosine triphosphate (ATP), a biochemical that releases energy in cells and aids in energy transfer.

The study results published in the Proceedings of the National Academy of Sciences (PNAS), describe the combination of geometrical modeling and engineering as well as nanotechnology to create circuitry that uses 1.5 × 1.5 cm in area and the naturally occurring protein to operate.

A More Sustainable Option

Other than the mere presence of a human energy source in a machine, an astounding aspect of the device is how, as opposed to electrical energy that produces heat, the biological agent powering this new computer enables it to remain cool and energy efficient, making it more sustainable.

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I am not surprised at all by this finding given the other issues with pollution such as cancer from carcinogens, asthma, sinus infections, etc.

Air pollution is a known culprit in lung and heart disease. Fine particulate matter, tiny particles, 1/30th the width of a human hair, are released into the air by power plants, factories, cars and trucks. These fine particles somehow invade the body’s defenses and do the most damage. Air quality is worst in urban areas with increased traffic. New research points out that air pollution negatively affects brain and cognitive development in young children and teenagers.

Moreover, Jennifer Weuve, an assistant professor of internal medicine at Rush Medical College, found that older women who had been exposed to high levels of the pollution experienced greater cognitive decline compared with other women their age (Archives of Internal Medicine, 2012). Other studies cite black carbon in the form of soot as a cause of cognitive decline in an aging population for both men and women. Simply put: Dirty air messes up the brain.

In a new study conducted by a research team at Umeå University in Sweden, the correlation between exposure to air pollution in residential areas and children’ and adolescents’ psychiatric health was studied. The results show that air pollution increased the need for prescribed psychiatric medication for a mental illness. “The results can mean that a decreased concentration of air pollution, first and foremost traffic-related air pollution, may reduce psychiatric disorders in children and adolescents,” says lead researcher Anna Oudin, the Unit for Occupational and Environmental Medicine at the Department of Public Health and Clinical Medicine.

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Nice.

In a pair of firsts, researchers at Case Western Reserve University and Massachusetts Institute of Technology have shown that the drug candidate phenanthriplatin can be more effective than an approved drug in vivo, and that a plant-virus-based carrier successfully delivers a drug in vivo.

Triple-negative breast cancer tumors of mice treated with the phenanthriplatin –carrying nanoparticles were four times smaller than those treated either with cisplatin, a common and related chemotherapy drug, or free phenanthriplatin injected intravenously into circulation.

The scientists believe the work, reported in the journal ACS Nano, is a promising step toward clinical trials.

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Very nice; researchers have now discovered a method for viewing deep brain imaging through using NIR light at wavelengths of 1600–1870nm Very big deal especially for patients with things like Giloblastoma Multiforme (GBM), and other neuro disorders and diseases.

I remember when my two aunts suffered from GBM, and many doctors could not get iimaging view in some areas of my aunts brains which would have been beneficial in understanding how ingrain the GBM was in their brain cells. So, hopefully this finding will help others in getting better answers to diseases like GBM and in turn better treatment as well developed.

Near-IR light at wavelengths of 1600–1870nm offers the best transmittance for deep brain imaging.

One of the major goals in neuroscience is to image the structure of the brain at cellular resolution. However, achieving deep brain tissue imaging has posed a significant challenge because of technical limitations in accessing wavelengths beyond 950nm. Recently, the availability of new technologies, such as suitable near-infrared (NIR) detectors and femtosecond laser sources, offer great potential for deep brain imaging. Now, we have discovered a ‘ golden window’ that uses NIR light at wavelengths of 1600–1870nm, which offers the optimal transmittance for deep brain imaging. 1, 2.

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Robotic exoskeletons, long a staple of sci-fi novels, comic books, and movies, are now part of the real world—and they’ve mostly followed the sci-fi model. That is, exoskeletons are wearable robots. All metal, all the time. But metal suits are heavy and power hungry, and the human body isn’t metal. If you actually plan to use an exoskeleton for an extended period of time, this can be a bit of a design flaw.

That’s where a new exosuit developed by SRI International is looking to flip the script. Instead of working to build exoskeletons—which are rigid like their namesake—SRI is using soft robotics to make lightweight, wearable “exomuscles” and “exotendons.”

Instead of a human-shaped heavy metal frame, SRI’s exosuit is soft, pliable, and intelligent. The suit learns and adapts to its wearer’s movements to give them a boost when needed. It’s quick to put on and relatively energy efficient.

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